dna repair complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. (Gene Ontology, GO_1990391)
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Genes

357 proteins co-occuring with the dna repair complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MSH2 mutS homolog 2 0.577999
XPC xeroderma pigmentosum, complementation group C 0.441048
MSH3 mutS homolog 3 0.425741
MLH1 mutL homolog 1 0.417502
ERCC1 excision repair cross-complementation group 1 0.400968
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.361659
MSH6 mutS homolog 6 0.349509
EXO1 exonuclease 1 0.29497
ERCC4 excision repair cross-complementation group 4 0.256731
PRPH peripherin 0.207428
RAD23B RAD23 homolog B (S. cerevisiae) 0.205991
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.195966
FEN1 flap structure-specific endonuclease 1 0.176305
XPA xeroderma pigmentosum, complementation group A 0.158971
RAD52 RAD52 homolog (S. cerevisiae) 0.156114
ERCC5 excision repair cross-complementation group 5 0.151666
PCNA proliferating cell nuclear antigen 0.147984
MLH3 mutL homolog 3 0.145912
RAD51 RAD51 recombinase 0.145448
SLX4 SLX4 structure-specific endonuclease subunit 0.14277
OGG1 8-oxoguanine DNA glycosylase 0.141664
RAD50 RAD50 homolog (S. cerevisiae) 0.140631
CHEK1 checkpoint kinase 1 0.139992
DCLRE1A DNA cross-link repair 1A 0.139801
CETN2 centrin, EF-hand protein, 2 0.139748
MUS81 MUS81 structure-specific endonuclease subunit 0.139668
UNG uracil-DNA glycosylase 0.139157
TLE6 transducin-like enhancer of split 6 0.139114
TERF2 telomeric repeat binding factor 2 0.13849
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.138442
AICDA activation-induced cytidine deaminase 0.138418
POLH polymerase (DNA directed), eta 0.136719
TDP1 tyrosyl-DNA phosphodiesterase 1 0.136505
FANCD2 Fanconi anemia, complementation group D2 0.136325
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.136294
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.136273
ATM ATM serine/threonine kinase 0.135776
ERCC2 excision repair cross-complementation group 2 0.13554
C9ORF84 chromosome 9 open reading frame 84 0.135382
BRCA1 breast cancer 1, early onset 0.135298
GH2 growth hormone 2 0.13496
HUS1 HUS1 checkpoint homolog (S. pombe) 0.134418
MUTYH mutY homolog 0.134213
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.134155
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.133916
SLX4IP SLX4 interacting protein 0.133826
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.133723
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.133433
NEFM neurofilament, medium polypeptide 0.13343
RFC3 replication factor C (activator 1) 3, 38kDa 0.133405
WRN Werner syndrome, RecQ helicase-like 0.133394
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.133355
RFC4 replication factor C (activator 1) 4, 37kDa 0.13333
FAN1 FANCD2/FANCI-associated nuclease 1 0.132986
RFC1 replication factor C (activator 1) 1, 145kDa 0.132917
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.132822
S100B S100 calcium binding protein B 0.132775
DDB1 damage-specific DNA binding protein 1, 127kDa 0.132574
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.132466
LIG4 ligase IV, DNA, ATP-dependent 0.132351
RAD9A RAD9 homolog A (S. pombe) 0.132272
RFC2 replication factor C (activator 1) 2, 40kDa 0.132213
DTX2 deltex 2, E3 ubiquitin ligase 0.1319
ATR ATR serine/threonine kinase 0.131489
CCDC26 CCDC26 long non-coding RNA 0.13114
H2AFX H2A histone family, member X 0.131064
SWSAP1 SWIM-type zinc finger 7 associated protein 1 0.130971
HMGB1 high mobility group box 1 0.13093
EME2 essential meiotic structure-specific endonuclease subunit 2 0.130853
ALKBH3 alkB, alkylation repair homolog 3 (E. coli) 0.130634
TP53 tumor protein p53 0.130516
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.13036
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.130008
TERF2IP telomeric repeat binding factor 2, interacting protein 0.129606
UBE2N ubiquitin-conjugating enzyme E2N 0.12959
TOP1 topoisomerase (DNA) I 0.129373
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.129309
BRCA2 breast cancer 2, early onset 0.129281
PLRG1 pleiotropic regulator 1 0.127963
NOTO notochord homeobox 0.127532
POLL polymerase (DNA directed), lambda 0.127258
TDG thymine-DNA glycosylase 0.126869
LIG1 ligase I, DNA, ATP-dependent 0.126829
TOPBP1 topoisomerase (DNA) II binding protein 1 0.126794
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 0.126759
APRT adenine phosphoribosyltransferase 0.126518
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.126477
KNTC1 kinetochore associated 1 0.126457
SMC6 structural maintenance of chromosomes 6 0.1264
RPA4 replication protein A4, 30kDa 0.126072
DCLRE1C DNA cross-link repair 1C 0.125581
NHEJ1 nonhomologous end-joining factor 1 0.12552
KRAS Kirsten rat sarcoma viral oncogene homolog 0.12542
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.124613
EME1 essential meiotic structure-specific endonuclease 1 0.124409
ASCC3 activating signal cointegrator 1 complex subunit 3 0.12436
C19ORF40 chromosome 19 open reading frame 40 0.123914
GH1 growth hormone 1 0.123685
GCLM glutamate-cysteine ligase, modifier subunit 0.123354
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.123121
LIG3 ligase III, DNA, ATP-dependent 0.123013
KLF1 Kruppel-like factor 1 (erythroid) 0.122657
POLM polymerase (DNA directed), mu 0.122461
CLSPN claspin 0.122089
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.121173
RUNX3 runt-related transcription factor 3 0.121018
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.120947
SETMAR SET domain and mariner transposase fusion gene 0.120693
NBN nibrin 0.120677
BCAS2 breast carcinoma amplified sequence 2 0.120547
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.120035
HRAS Harvey rat sarcoma viral oncogene homolog 0.119815
TOP3A topoisomerase (DNA) III alpha 0.11858
RMI1 RecQ mediated genome instability 1 0.118337
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.118252
RNASEH1 ribonuclease H1 0.117937
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.117606
CCNH cyclin H 0.117586
GATA2 GATA binding protein 2 0.117066
FANCF Fanconi anemia, complementation group F 0.116446
PARP1 poly (ADP-ribose) polymerase 1 0.116031
RAG1 recombination activating gene 1 0.115715
DHFR dihydrofolate reductase 0.115371
MDC1 mediator of DNA-damage checkpoint 1 0.115371
APLF aprataxin and PNKP like factor 0.114826
RAD51C RAD51 paralog C 0.114583
CDC5L cell division cycle 5-like 0.114559
SMC5 structural maintenance of chromosomes 5 0.114062
FANCI Fanconi anemia, complementation group I 0.113602
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.113029
RAG2 recombination activating gene 2 0.112915
REV1 REV1, polymerase (DNA directed) 0.112363
FANCM Fanconi anemia, complementation group M 0.11235
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.111227
PNKP polynucleotide kinase 3'-phosphatase 0.111077
DUT deoxyuridine triphosphatase 0.110939
PRPF19 pre-mRNA processing factor 19 0.110589
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.109405
RAD54L RAD54-like (S. cerevisiae) 0.108822
XRCC6BP1 XRCC6 binding protein 1 0.108671
MEA1 male-enhanced antigen 1 0.10858
NBAS neuroblastoma amplified sequence 0.108086
RAD17 RAD17 homolog (S. pombe) 0.107693
RAD18 RAD18 E3 ubiquitin protein ligase 0.107693
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.107038
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.10678
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.106252
TRIM7 tripartite motif containing 7 0.106252
ZBED9 zinc finger, BED-type containing 9 0.106252
CIRBP-AS1 CIRBP antisense RNA 1 0.106252
ATXN7L1 ataxin 7-like 1 0.106252
HEATR4 HEAT repeat containing 4 0.106252
RAD54B RAD54 homolog B (S. cerevisiae) 0.106252
DEPDC4 DEP domain containing 4 0.106252
ZBED8 zinc finger, BED-type containing 8 0.106252
USP42 ubiquitin specific peptidase 42 0.106252
PLSCR2 phospholipid scramblase 2 0.106252
FAM49A family with sequence similarity 49, member A 0.106252
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 0.106186
FBXO24 F-box protein 24 0.105292
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.104297
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.104067
TP53BP1 tumor protein p53 binding protein 1 0.104049
CDK7 cyclin-dependent kinase 7 0.102313
RAD51AP1 RAD51 associated protein 1 0.102218
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 0.102104
RING1 ring finger protein 1 0.101914
RPA2 replication protein A2, 32kDa 0.101801
UIMC1 ubiquitin interaction motif containing 1 0.100993
TDP2 tyrosyl-DNA phosphodiesterase 2 0.100954
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.100799
PARP3 poly (ADP-ribose) polymerase family, member 3 0.100543
UBA2 ubiquitin-like modifier activating enzyme 2 0.100524
MSL1 male-specific lethal 1 homolog (Drosophila) 0.099567
PARP2 poly (ADP-ribose) polymerase 2 0.099547
XRRA1 X-ray radiation resistance associated 1 0.099103
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.098361
FBXL12 F-box and leucine-rich repeat protein 12 0.097859
GCLC glutamate-cysteine ligase, catalytic subunit 0.097586
HMOX1 heme oxygenase 1 0.096883
FBXO28 F-box protein 28 0.096519
BLM Bloom syndrome, RecQ helicase-like 0.096475
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.095645
GNG10 guanine nucleotide binding protein (G protein), gamma 10 0.095645
BANP BTG3 associated nuclear protein 0.09489
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.094667
POLD2 polymerase (DNA directed), delta 2, accessory subunit 0.094418
SBNO2 strawberry notch homolog 2 (Drosophila) 0.094418
EGFR epidermal growth factor receptor 0.094078
SETD3 SET domain containing 3 0.093965
PLP1 proteolipid protein 1 0.09392
BMP8A bone morphogenetic protein 8a 0.0933
UBE2K ubiquitin-conjugating enzyme E2K 0.09277
H2AFY H2A histone family, member Y 0.092605
DCAF11 DDB1 and CUL4 associated factor 11 0.092582
HIST1H4E histone cluster 1, H4e 0.092464
HIST2H4A histone cluster 2, H4a 0.092464
HIST1H4A histone cluster 1, H4a 0.092464
HIST1H4J histone cluster 1, H4j 0.092464
HIST1H4H histone cluster 1, H4h 0.092464
HIST1H4I histone cluster 1, H4i 0.092464
HIST1H4D histone cluster 1, H4d 0.092464
HIST1H4C histone cluster 1, H4c 0.092464
HIST2H4B histone cluster 2, H4b 0.092464
HIST1H4K histone cluster 1, H4k 0.092464
HIST1H4B histone cluster 1, H4b 0.092464
HIST4H4 histone cluster 4, H4 0.092441
HIST1H4L histone cluster 1, H4l 0.092441
HIST1H4F histone cluster 1, H4f 0.092441
ATP11A ATPase, class VI, type 11A 0.092206
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.09216
POLQ polymerase (DNA directed), theta 0.091925
BCR breakpoint cluster region 0.091807
PARP4 poly (ADP-ribose) polymerase family, member 4 0.091211
RNF169 ring finger protein 169 0.090949
RAB9B RAB9B, member RAS oncogene family 0.090684
RNF144A ring finger protein 144A 0.090393
HIST1H2AJ histone cluster 1, H2aj 0.090199
H2AFJ H2A histone family, member J 0.090199
HIST1H2AM histone cluster 1, H2am 0.090199
HIST1H2AD histone cluster 1, H2ad 0.090199
HIST1H2AH histone cluster 1, H2ah 0.090175
HIST1H2AG histone cluster 1, H2ag 0.090102
H2AFY2 H2A histone family, member Y2 0.090005
HIST1H2AB histone cluster 1, H2ab 0.089957
HIST1H2AE histone cluster 1, H2ae 0.089957
H2AFV H2A histone family, member V 0.089933
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.089786
H2AFB1 H2A histone family, member B1 0.089762
H2AFB2 H2A histone family, member B2 0.08954
POT1 protection of telomeres 1 0.088751
CELA3A chymotrypsin-like elastase family, member 3A 0.088451
ZNF461 zinc finger protein 461 0.088351
TOP2B topoisomerase (DNA) II beta 180kDa 0.088276
C6ORF15 chromosome 6 open reading frame 15 0.088201
DNASE2 deoxyribonuclease II, lysosomal 0.088026
BARD1 BRCA1 associated RING domain 1 0.087851
EEF2 eukaryotic translation elongation factor 2 0.087851
TCF19 transcription factor 19 0.087446
TEP1 telomerase-associated protein 1 0.087344
DNTT DNA nucleotidylexotransferase 0.087014
IL3 interleukin 3 0.086812
RAD51B RAD51 paralog B 0.086761
FANCA Fanconi anemia, complementation group A 0.086735
TRIM4 tripartite motif containing 4 0.086504
CCNA2 cyclin A2 0.086478
RBBP8 retinoblastoma binding protein 8 0.08622
MSH4 mutS homolog 4 0.085783
CP ceruloplasmin (ferroxidase) 0.085367
HIST1H2BH histone cluster 1, H2bh 0.085289
HIST2H2BF histone cluster 2, H2bf 0.085289
HIST3H2BB histone cluster 3, H2bb 0.085289
HIST1H2BD histone cluster 1, H2bd 0.085289
HIST1H2BF histone cluster 1, H2bf 0.085185
HIST1H2BC histone cluster 1, H2bc 0.085185
HIST1H2BA histone cluster 1, H2ba 0.085106
PHGDH phosphoglycerate dehydrogenase 0.085028
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.08482
AUTS2 autism susceptibility candidate 2 0.084768
PARK2 parkin RBR E3 ubiquitin protein ligase 0.084426
NPAP1 nuclear pore associated protein 1 0.083924
APTX aprataxin 0.083845
TSN translin 0.083765
RAB11FIP5 RAB11 family interacting protein 5 (class I) 0.083713
CCHCR1 coiled-coil alpha-helical rod protein 1 0.08366
FER fer (fps/fes related) tyrosine kinase 0.083528
HOXD13 homeobox D13 0.08334
CHEK2 checkpoint kinase 2 0.083233
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.083233
FLT3 fms-related tyrosine kinase 3 0.082591
GMCL1 germ cell-less, spermatogenesis associated 1 0.082214
ERCC6 excision repair cross-complementation group 6 0.082106
PAPD7 PAP associated domain containing 7 0.082079
SOX2 SRY (sex determining region Y)-box 2 0.08151
MEIG1 meiosis/spermiogenesis associated 1 0.081266
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.081074
SUB1 SUB1 homolog (S. cerevisiae) 0.081047
MPG N-methylpurine-DNA glycosylase 0.080883
VCX2 variable charge, X-linked 2 0.080609
VCX3B variable charge, X-linked 3B 0.080609
VCX variable charge, X-linked 0.080609
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.08039
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.079949
MSH5 mutS homolog 5 0.079756
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.079479
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.079147
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.079119
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.078309
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.078197
H3F3B H3 histone, family 3B (H3.3B) 0.078058
H3F3A H3 histone, family 3A 0.078058
TFIP11 tuftelin interacting protein 11 0.078058
VCX3A variable charge, X-linked 3A 0.078002
NIT2 nitrilase family, member 2 0.077749
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 0.077692
FANCC Fanconi anemia, complementation group C 0.077664
FBXL19 F-box and leucine-rich repeat protein 19 0.077664
CCNA1 cyclin A1 0.077325
TRIM3 tripartite motif containing 3 0.077269
MIDN midnolin 0.07693
HDAC9 histone deacetylase 9 0.076647
HIST2H2AC histone cluster 2, H2ac 0.07659
HIST2H2AA4 histone cluster 2, H2aa4 0.076562
HIST2H2AA3 histone cluster 2, H2aa3 0.076562
CDKN2A cyclin-dependent kinase inhibitor 2A 0.076305
SETD8 SET domain containing (lysine methyltransferase) 8 0.076277
ASXL1 additional sex combs like transcriptional regulator 1 0.075821
MVP major vault protein 0.075707
PSMC3IP PSMC3 interacting protein 0.075679
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.075679
KDM4D lysine (K)-specific demethylase 4D 0.075393
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.075306
PTCH1 patched 1 0.075249
MIR100 microRNA 100 0.075192
NONO non-POU domain containing, octamer-binding 0.075163
RRM1 ribonucleotide reductase M1 0.075134
CDK2 cyclin-dependent kinase 2 0.075019
PRKY protein kinase, Y-linked, pseudogene 0.074876
PRKX protein kinase, X-linked 0.074847
CCNO cyclin O 0.074703
ISPD isoprenoid synthase domain containing 0.074617
FXN frataxin 0.074474
AVEN apoptosis, caspase activation inhibitor 0.07433
ZNF350 zinc finger protein 350 0.074069
EYA4 EYA transcriptional coactivator and phosphatase 4 0.074069
WDR48 WD repeat domain 48 0.073751
IARS isoleucyl-tRNA synthetase 0.073519
PPP1R12C protein phosphatase 1, regulatory subunit 12C 0.07349
GRHL1 grainyhead-like 1 (Drosophila) 0.07349
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.073259
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.073026
ERCC3 excision repair cross-complementation group 3 0.073026
TSC1 tuberous sclerosis 1 0.072968
KAT5 K(lysine) acetyltransferase 5 0.072822
TENM4 teneurin transmembrane protein 4 0.072589
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 0.072298
SPO11 SPO11 meiotic protein covalently bound to DSB 0.071889
ECH1 enoyl CoA hydratase 1, peroxisomal 0.07186
UVRAG UV radiation resistance associated 0.07183
IGF1R insulin-like growth factor 1 receptor 0.071713
FOS FBJ murine osteosarcoma viral oncogene homolog 0.071537
NOTCH2NL notch 2 N-terminal like 0.07139
TREX2 three prime repair exonuclease 2 0.07139
NOTCH2 notch 2 0.070921
RECQL4 RecQ protein-like 4 0.070745
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.070538
GADD45A growth arrest and DNA-damage-inducible, alpha 0.070538
TRIM28 tripartite motif containing 28 0.070538
PPP4C protein phosphatase 4, catalytic subunit 0.070479
RNF4 ring finger protein 4 0.070331
TRIP13 thyroid hormone receptor interactor 13 0.070331
CFH complement factor H 0.070243
PMP22 peripheral myelin protein 22 0.070125
PIF1 PIF1 5'-to-3' DNA helicase 0.069918
BCCIP BRCA2 and CDKN1A interacting protein 0.069859
FIP1L1 factor interacting with PAPOLA and CPSF1 0.06983
CDA cytidine deaminase 0.069771