disulfiram-6210 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the disulfiram-6210 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF7IP2 activating transcription factor 7 interacting protein 2
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
C1ORF115 chromosome 1 open reading frame 115
C9ORF9 chromosome 9 open reading frame 9
CAMTA1 calmodulin binding transcription activator 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CLCN7 chloride channel, voltage-sensitive 7
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EPHA2 EPH receptor A2
FAM189A2 family with sequence similarity 189, member A2
FBXL18 F-box and leucine-rich repeat protein 18
FKBP4 FK506 binding protein 4, 59kDa
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GPR153 G protein-coupled receptor 153
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IL15 interleukin 15
IRF6 interferon regulatory factor 6
JUN jun proto-oncogene
KLHL23 kelch-like family member 23
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4 microtubule-associated protein 4
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MT4 metallothionein 4
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NREP neuronal regeneration related protein
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTRF polymerase I and transcript release factor
RANBP3 RAN binding protein 3
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SIGLEC6 sialic acid binding Ig-like lectin 6
SKIL SKI-like proto-oncogene
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SND1-IT1 SND1 intronic transcript 1
SNX13 sorting nexin 13
SOCS2 suppressor of cytokine signaling 2
TES testin LIM domain protein
TICAM1 toll-like receptor adaptor molecule 1
TMEM50B transmembrane protein 50B
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TXNRD1 thioredoxin reductase 1
ULBP2 UL16 binding protein 2
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZC3H7B zinc finger CCCH-type containing 7B
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
ARMC6 armadillo repeat containing 6
ARRB2 arrestin, beta 2
B3GNT1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BACE1 beta-site APP-cleaving enzyme 1
BCORL1 BCL6 corepressor-like 1
BTF3P11 basic transcription factor 3 pseudogene 11
C12ORF29 chromosome 12 open reading frame 29
C2ORF44 chromosome 2 open reading frame 44
C5ORF45 chromosome 5 open reading frame 45
CDK9 cyclin-dependent kinase 9
CENPJ centromere protein J
CISH cytokine inducible SH2-containing protein
CLDN3 claudin 3
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COMMD10 COMM domain containing 10
CPTP ceramide-1-phosphate transfer protein
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERO1L ERO1-like (S. cerevisiae)
EXOC2 exocyst complex component 2
FAM86C1 family with sequence similarity 86, member C1
FCHO1 FCH domain only 1
FMO4 flavin containing monooxygenase 4
FZD3 frizzled class receptor 3
GJA1 gap junction protein, alpha 1, 43kDa
GLI3 GLI family zinc finger 3
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTF2I general transcription factor IIi
H2AFJ H2A histone family, member J
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB3 high mobility group box 3
HRAS Harvey rat sarcoma viral oncogene homolog
IGSF3 immunoglobulin superfamily, member 3
ISOC1 isochorismatase domain containing 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0125 KIAA0125
KIAA0556 KIAA0556
KRT13 keratin 13, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMCD1 LIM and cysteine-rich domains 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAGEH1 melanoma antigen family H1
MED9 mediator complex subunit 9
METTL16 methyltransferase like 16
MITF microphthalmia-associated transcription factor
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL17 mitochondrial ribosomal protein L17
MSH2 mutS homolog 2
MXD3 MAX dimerization protein 3
NBEA neurobeachin
NCAM2 neural cell adhesion molecule 2
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NES nestin
NMU neuromedin U
OCEL1 occludin/ELL domain containing 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARPBP PARP1 binding protein
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLA2G10 phospholipase A2, group X
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPOX protoporphyrinogen oxidase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRKCD protein kinase C, delta
RAB4A RAB4A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIC8B RIC8 guanine nucleotide exchange factor B
RPL23AP7 ribosomal protein L23a pseudogene 7
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SPC25 SPC25, NDC80 kinetochore complex component
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYNJ2BP synaptojanin 2 binding protein
SYT17 synaptotagmin XVII
THOC1 THO complex 1
TMEM104 transmembrane protein 104
TRAF5 TNF receptor-associated factor 5
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TTC26 tetratricopeptide repeat domain 26
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZNF211 zinc finger protein 211
ZNF226 zinc finger protein 226
ZNF276 zinc finger protein 276
ZNF665 zinc finger protein 665