dirithromycin-7446 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dirithromycin-7446 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAP2 ArfGAP with dual PH domains 2
ADARB1 adenosine deaminase, RNA-specific, B1
AIF1 allograft inflammatory factor 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP6 bone morphogenetic protein 6
C5ORF45 chromosome 5 open reading frame 45
CAPN5 calpain 5
CD53 CD53 molecule
CELA3A chymotrypsin-like elastase family, member 3A
CLTC clathrin, heavy chain (Hc)
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCN decorin
EHBP1L1 EH domain binding protein 1-like 1
ELOVL4 ELOVL fatty acid elongase 4
ELOVL5 ELOVL fatty acid elongase 5
FAM186A family with sequence similarity 186, member A
FAM212B family with sequence similarity 212, member B
FAM65A family with sequence similarity 65, member A
FOXN3 forkhead box N3
FUS FUS RNA binding protein
GGT1 gamma-glutamyltransferase 1
GHRH growth hormone releasing hormone
GLS2 glutaminase 2 (liver, mitochondrial)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
GVINP1 GTPase, very large interferon inducible pseudogene 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEMK1 HemK methyltransferase family member 1
HIST1H2BB histone cluster 1, H2bb
HIST1H4D histone cluster 1, H4d
HSPB6 heat shock protein, alpha-crystallin-related, B6
ICOSLG inducible T-cell co-stimulator ligand
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JMJD4 jumonji domain containing 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF25 kinesin family member 25
LPAR1 lysophosphatidic acid receptor 1
LPIN1 lipin 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MALL mal, T-cell differentiation protein-like
MAP4 microtubule-associated protein 4
MAPK8 mitogen-activated protein kinase 8
MCF2L MCF.2 cell line derived transforming sequence-like
MFAP3L microfibrillar-associated protein 3-like
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NKX2-5 NK2 homeobox 5
NOS1 nitric oxide synthase 1 (neuronal)
NOVA2 neuro-oncological ventral antigen 2
NRSN2 neurensin 2
OPRK1 opioid receptor, kappa 1
OVGP1 oviductal glycoprotein 1, 120kDa
PALM paralemmin
PARD6B par-6 family cell polarity regulator beta
PDCD6 programmed cell death 6
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDB1 pleckstrin homology-like domain, family B, member 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKCB protein kinase C, beta
PSG11 pregnancy specific beta-1-glycoprotein 11
RABGAP1L RAB GTPase activating protein 1-like
RECQL5 RecQ protein-like 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFT2D2 SFT2 domain containing 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLPI secretory leukocyte peptidase inhibitor
SPTBN1 spectrin, beta, non-erythrocytic 1
SRCAP Snf2-related CREBBP activator protein
STAB1 stabilin 1
STMN4 stathmin-like 4
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TMC6 transmembrane channel-like 6
TMEM19 transmembrane protein 19
TONSL tonsoku-like, DNA repair protein
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VSNL1 visinin-like 1
ZBED1 zinc finger, BED-type containing 1
ZC3H13 zinc finger CCCH-type containing 13

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ADCY6 adenylate cyclase 6
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG6 adhesion G protein-coupled receptor G6
AEN apoptosis enhancing nuclease
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AXIN1 axin 1
BCL2L2 BCL2-like 2
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCNT1 cyclin T1
CDC37L1 cell division cycle 37-like 1
CERK ceramide kinase
CISH cytokine inducible SH2-containing protein
CLASP1 cytoplasmic linker associated protein 1
CLCN5 chloride channel, voltage-sensitive 5
CTSK cathepsin K
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYR61 cysteine-rich, angiogenic inducer, 61
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DUSP5 dual specificity phosphatase 5
EGR3 early growth response 3
EPHA2 EPH receptor A2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCC1 GRIP and coiled-coil domain containing 1
GPR27 G protein-coupled receptor 27
GPR87 G protein-coupled receptor 87
GSTT1 glutathione S-transferase theta 1
H2AFY2 H2A histone family, member Y2
HIST1H2AG histone cluster 1, H2ag
IRF9 interferon regulatory factor 9
IRX4 iroquois homeobox 4
JRKL JRK-like
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLF11 Kruppel-like factor 11
LAMA3 laminin, alpha 3
LINS lines homolog (Drosophila)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC20 leucine rich repeat containing 20
LZTR1 leucine-zipper-like transcription regulator 1
MANBA mannosidase, beta A, lysosomal
MED15 mediator complex subunit 15
METTL16 methyltransferase like 16
MFSD10 major facilitator superfamily domain containing 10
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTCL1 microtubule crosslinking factor 1
NBEAL2 neurobeachin-like 2
NISCH nischarin
NMRK1 nicotinamide riboside kinase 1
NPY1R neuropeptide Y receptor Y1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PER3 period circadian clock 3
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRR3 proline rich 3
PTCD2 pentatricopeptide repeat domain 2
PTK6 protein tyrosine kinase 6
PTOV1 prostate tumor overexpressed 1
RANGRF RAN guanine nucleotide release factor
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBBP5 retinoblastoma binding protein 5
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SF3A2 splicing factor 3a, subunit 2, 66kDa
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SOX3 SRY (sex determining region Y)-box 3
SPIDR scaffolding protein involved in DNA repair
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK25 serine/threonine kinase 25
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TESK2 testis-specific kinase 2
TMEM39B transmembrane protein 39B
TNNT1 troponin T type 1 (skeletal, slow)
TPRA1 transmembrane protein, adipocyte asscociated 1
TPST1 tyrosylprotein sulfotransferase 1
UBXN6 UBX domain protein 6
ULBP2 UL16 binding protein 2
VGF VGF nerve growth factor inducible
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR4 WD repeat domain 4
ZBTB3 zinc finger and BTB domain containing 3
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF212 zinc finger protein 212
ZNF226 zinc finger protein 226
ZNF250 zinc finger protein 250
ZNF286A zinc finger protein 286A
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF394 zinc finger protein 394
ZNF668 zinc finger protein 668
ZXDC ZXD family zinc finger C