dirithromycin-2863 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the dirithromycin-2863 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AK1 adenylate kinase 1
AKAP11 A kinase (PRKA) anchor protein 11
AKAP6 A kinase (PRKA) anchor protein 6
AMPD3 adenosine monophosphate deaminase 3
ANG angiogenin, ribonuclease, RNase A family, 5
ARC activity-regulated cytoskeleton-associated protein
ATM ATM serine/threonine kinase
BAHCC1 BAH domain and coiled-coil containing 1
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C17ORF59 chromosome 17 open reading frame 59
C19ORF66 chromosome 19 open reading frame 66
CA4 carbonic anhydrase IV
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD58 CD58 molecule
CD82 CD82 molecule
CDIP1 cell death-inducing p53 target 1
CDKL5 cyclin-dependent kinase-like 5
CDRT1 CMT1A duplicated region transcript 1
CES3 carboxylesterase 3
CFLAR CASP8 and FADD-like apoptosis regulator
CNOT4 CCR4-NOT transcription complex, subunit 4
COPA coatomer protein complex, subunit alpha
DHRS12 dehydrogenase/reductase (SDR family) member 12
DNASE1L2 deoxyribonuclease I-like 2
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EIF5A2 eukaryotic translation initiation factor 5A2
ELN elastin
GAB1 GRB2-associated binding protein 1
GAS7 growth arrest-specific 7
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPER1 G protein-coupled estrogen receptor 1
HES2 hes family bHLH transcription factor 2
HIST1H2AK histone cluster 1, H2ak
HNRNPM heterogeneous nuclear ribonucleoprotein M
IL11 interleukin 11
INTS3 integrator complex subunit 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCTD17 potassium channel tetramerization domain containing 17
KDM7A lysine (K)-specific demethylase 7A
KLHL25 kelch-like family member 25
LGALS8 lectin, galactoside-binding, soluble, 8
LRRC1 leucine rich repeat containing 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MCAM melanoma cell adhesion molecule
MED18 mediator complex subunit 18
MXD3 MAX dimerization protein 3
MYCNOS MYCN opposite strand
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUMA1 nuclear mitotic apparatus protein 1
NXPH4 neurexophilin 4
PAWR PRKC, apoptosis, WT1, regulator
PCDHB6 protocadherin beta 6
PHF20 PHD finger protein 20
PLCH1 phospholipase C, eta 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLLP plasmolipin
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PQLC3 PQ loop repeat containing 3
PRAMEF10 PRAME family member 10
PRKG2 protein kinase, cGMP-dependent, type II
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFPL1S RFPL1 antisense RNA 1
RHOH ras homolog family member H
RND1 Rho family GTPase 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAMD4A sterile alpha motif domain containing 4A
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SLC16A4 solute carrier family 16, member 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A30 solute carrier family 25, member 30
SPRED2 sprouty-related, EVH1 domain containing 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TLDC1 TBC/LysM-associated domain containing 1
TRIM16 tripartite motif containing 16
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSNAXIP1 translin-associated factor X interacting protein 1
UHRF1BP1L UHRF1 binding protein 1-like
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP22 ubiquitin specific peptidase 22
USP34 ubiquitin specific peptidase 34
USP46 ubiquitin specific peptidase 46
VEGFB vascular endothelial growth factor B
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1
ZBTB7A zinc finger and BTB domain containing 7A
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF286A zinc finger protein 286A
ZNF358 zinc finger protein 358
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD14A abhydrolase domain containing 14A
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTL8 actin-like 8
ADCY7 adenylate cyclase 7
AGMAT agmatine ureohydrolase (agmatinase)
ANXA2P3 annexin A2 pseudogene 3
ARHGAP10 Rho GTPase activating protein 10
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BATF basic leucine zipper transcription factor, ATF-like
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C14ORF79 chromosome 14 open reading frame 79
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF54 chromosome 2 open reading frame 54
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK4 calcium/calmodulin-dependent protein kinase IV
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCF1 cardiotrophin-like cytokine factor 1
CORO7 coronin 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF4 DDB1 and CUL4 associated factor 4
DGKE diacylglycerol kinase, epsilon 64kDa
DYSF dysferlin
ELOVL2 ELOVL fatty acid elongase 2
ELOVL4 ELOVL fatty acid elongase 4
EPHX2 epoxide hydrolase 2, cytoplasmic
EXO5 exonuclease 5
FAM198B family with sequence similarity 198, member B
FAM46C family with sequence similarity 46, member C
FBXO4 F-box protein 4
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAMT guanidinoacetate N-methyltransferase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR143 G protein-coupled receptor 143
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIST1H2AI histone cluster 1, H2ai
HIST1H4E histone cluster 1, H4e
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC4 homeobox C4
HOXC5 homeobox C5
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INPP1 inositol polyphosphate-1-phosphatase
KDM8 lysine (K)-specific demethylase 8
KIAA0513 KIAA0513
KIAA1107 KIAA1107
KLC2 kinesin light chain 2
KLHL36 kelch-like family member 36
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRI1 KRI1 homolog (S. cerevisiae)
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
MAPK10 mitogen-activated protein kinase 10
MBNL3 muscleblind-like splicing regulator 3
MED9 mediator complex subunit 9
MEFV Mediterranean fever
METTL16 methyltransferase like 16
MGC12488
MMP9 matrix metallopeptidase 9
MON1B MON1 secretory trafficking family member B
MSMB microseminoprotein, beta-
NLRX1 NLR family member X1
NOL10 nucleolar protein 10
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCDHA5 protocadherin alpha 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PGBD5 piggyBac transposable element derived 5
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNPLA6 patatin-like phospholipase domain containing 6
POLH polymerase (DNA directed), eta
PTDSS2 phosphatidylserine synthase 2
ROM1 retinal outer segment membrane protein 1
SECTM1 secreted and transmembrane 1
SIRT6 sirtuin 6
SKI SKI proto-oncogene
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSBP3 single stranded DNA binding protein 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TLN1 talin 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSPAN5 tetraspanin 5
USB1 U6 snRNA biogenesis 1
YY2 YY2 transcription factor
ZC3H3 zinc finger CCCH-type containing 3
ZNF205 zinc finger protein 205
ZNF280D zinc finger protein 280D
ZNF551 zinc finger protein 551