directed Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

263 genes co-occuring with the biological term directed in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACTB actin, beta
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADORA2B adenosine A2b receptor
ADRB1 adrenoceptor beta 1
AEBP1 AE binding protein 1
AFP alpha-fetoprotein
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ANGPT2 angiopoietin 2
ANXA2 annexin A2
APC adenomatous polyposis coli
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOH apolipoprotein H (beta-2-glycoprotein I)
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGAP1 Rho GTPase activating protein 1
ARHGAP31 Rho GTPase activating protein 31
ARRB1 arrestin, beta 1
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATRN attractin
BCR breakpoint cluster region
BDKRB2 bradykinin receptor B2
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C5AR1 complement component 5a receptor 1
CA9 carbonic anhydrase IX
CARD8 caspase recruitment domain family, member 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CD1A CD1a molecule
CD2AP CD2-associated protein
CD47 CD47 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CENPE centromere protein E, 312kDa
CFP complement factor properdin
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRM3 cholinergic receptor, muscarinic 3
CKB creatine kinase, brain
CLDN11 claudin 11
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNR1 cannabinoid receptor 1 (brain)
COL17A1 collagen, type XVII, alpha 1
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTAG1B cancer/testis antigen 1B
CTAG2 cancer/testis antigen 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CUL5 cullin 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCC DCC netrin 1 receptor
DIAPH1 diaphanous-related formin 1
DICER1 dicer 1, ribonuclease type III
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSG1 desmoglein 1
E2F1 E2F transcription factor 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
F9 coagulation factor IX
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FLNA filamin A, alpha
FLT1 fms-related tyrosine kinase 1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GDF15 growth differentiation factor 15
GOLGA2 golgin A2
GP1BA glycoprotein Ib (platelet), alpha polypeptide
HCLS1 hematopoietic cell-specific Lyn substrate 1
HES6 hes family bHLH transcription factor 6
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HLA-A major histocompatibility complex, class I, A
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
ICMT isoprenylcysteine carboxyl methyltransferase
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL17A interleukin 17A
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
INS insulin
ITGA6 integrin, alpha 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIF1A kinesin family member 1A
KIFC1 kinesin family member C1
KIFC3 kinesin family member C3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEF1 lymphoid enhancer-binding factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEA1 melanoma antigen family A1
MAGEC2 melanoma antigen family C2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MARK2 MAP/microtubule affinity-regulating kinase 2
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MC4R melanocortin 4 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MECOM MDS1 and EVI1 complex locus
MIR122 microRNA 122
MIR132 microRNA 132
MIR499A microRNA 499a
MKI67 marker of proliferation Ki-67
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUTYH mutY homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
MYO1A myosin IA
NCOR1 nuclear receptor corepressor 1
NDC80 NDC80 kinetochore complex component
NELL1 NEL-like 1 (chicken)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH4 notch 4
NOV nephroblastoma overexpressed
NOX4 NADPH oxidase 4
NPY neuropeptide Y
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRBP1 nuclear receptor binding protein 1
NUF2 NUF2, NDC80 kinetochore complex component
OGG1 8-oxoguanine DNA glycosylase
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PACS1 phosphofurin acidic cluster sorting protein 1
PACS2 phosphofurin acidic cluster sorting protein 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PARD6A par-6 family cell polarity regulator alpha
PDE5A phosphodiesterase 5A, cGMP-specific
PF4 platelet factor 4
PF4V1 platelet factor 4 variant 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PON3 paraoxonase 3
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRAME preferentially expressed antigen in melanoma
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PROCR protein C receptor, endothelial
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBP3 retinol binding protein 3, interstitial
REN renin
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
SARM1 sterile alpha and TIR motif containing 1
SCFV single-chain Fv fragment
SCRIB scribbled planar cell polarity protein
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPC surfactant protein C
SHH sonic hedgehog
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
T T, brachyury homolog (mouse)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TARBP2 TAR (HIV-1) RNA binding protein 2
TCP1 t-complex 1
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TH tyrosine hydroxylase
TICAM1 toll-like receptor adaptor molecule 1
TKT transketolase
TLR3 toll-like receptor 3
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TSLP thymic stromal lymphopoietin
TTN titin
USF1 upstream transcription factor 1
VASP vasodilator-stimulated phosphoprotein
VEGFA vascular endothelial growth factor A
VIM vimentin
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WNT7A wingless-type MMTV integration site family, member 7A
ZEB1 zinc finger E-box binding homeobox 1