dipivefrine-7124 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the dipivefrine-7124 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACACA acetyl-CoA carboxylase alpha
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASF1A anti-silencing function 1A histone chaperone
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCL2A1 BCL2-related protein A1
BIN1 bridging integrator 1
BRWD1 bromodomain and WD repeat domain containing 1
BSPRY B-box and SPRY domain containing
C17ORF70 chromosome 17 open reading frame 70
CCNO cyclin O
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CENPJ centromere protein J
CLDN15 claudin 15
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CORO2A coronin, actin binding protein, 2A
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DENND2A DENN/MADD domain containing 2A
DFNB31 deafness, autosomal recessive 31
DGCR8 DGCR8 microprocessor complex subunit
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP1 dual specificity phosphatase 1
EFNA3 ephrin-A3
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPAS1 endothelial PAS domain protein 1
ERCC1 excision repair cross-complementation group 1
ERF Ets2 repressor factor
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GK glycerol kinase
GPATCH1 G patch domain containing 1
GPER1 G protein-coupled estrogen receptor 1
GPR17 G protein-coupled receptor 17
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3IP1 immediate early response 3 interacting protein 1
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KDM5C lysine (K)-specific demethylase 5C
KIF5C kinesin family member 5C
KLHL36 kelch-like family member 36
KRIT1 KRIT1, ankyrin repeat containing
LAMC2 laminin, gamma 2
LMBR1L limb development membrane protein 1-like
LPCAT3 lysophosphatidylcholine acyltransferase 3
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCMBP minichromosome maintenance complex binding protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PSD3 pleckstrin and Sec7 domain containing 3
PTGES prostaglandin E synthase
PTHLH parathyroid hormone-like hormone
PVT1 Pvt1 oncogene (non-protein coding)
RAB2A RAB2A, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RFK riboflavin kinase
RNASE4 ribonuclease, RNase A family, 4
RPL7 ribosomal protein L7
S100P S100 calcium binding protein P
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMOX spermine oxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STC1 stanniocalcin 1
STOM stomatin
TAOK3 TAO kinase 3
TCF4 transcription factor 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMC7 transmembrane channel-like 7
TMEM63A transmembrane protein 63A
TSFM Ts translation elongation factor, mitochondrial
TTC38 tetratricopeptide repeat domain 38
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
ZNF202 zinc finger protein 202
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ATP13A2 ATPase type 13A2
BCL9 B-cell CLL/lymphoma 9
C16ORF59 chromosome 16 open reading frame 59
C16ORF62 chromosome 16 open reading frame 62
CAPN5 calpain 5
CBX7 chromobox homolog 7
CCDC25 coiled-coil domain containing 25
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CFAP44 cilia and flagella associated protein 44
CHST10 carbohydrate sulfotransferase 10
CIR1 corepressor interacting with RBPJ, 1
CTGF connective tissue growth factor
CTSD cathepsin D
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DCAF13 DDB1 and CUL4 associated factor 13
DGKZ diacylglycerol kinase, zeta
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
DYSF dysferlin
ECH1 enoyl CoA hydratase 1, peroxisomal
EDC4 enhancer of mRNA decapping 4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
ERCC2 excision repair cross-complementation group 2
FAM102A family with sequence similarity 102, member A
FAM127B family with sequence similarity 127, member B
FIP1L1 factor interacting with PAPOLA and CPSF1
FPGS folylpolyglutamate synthase
GALE UDP-galactose-4-epimerase
GBX2 gastrulation brain homeobox 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRWD1 glutamate-rich WD repeat containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HYAL3 hyaluronoglucosaminidase 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRF2 interferon regulatory factor 2
JUNB jun B proto-oncogene
KIAA0556 KIAA0556
KIFC1 kinesin family member C1
KLHL3 kelch-like family member 3
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT15 keratin 15, type I
LY6E lymphocyte antigen 6 complex, locus E
MAGEA6 melanoma antigen family A6
MAN2B2 mannosidase, alpha, class 2B, member 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK3 mitogen-activated protein kinase 3
MAST3 microtubule associated serine/threonine kinase 3
MKS1 Meckel syndrome, type 1
MON1B MON1 secretory trafficking family member B
MSL1 male-specific lethal 1 homolog (Drosophila)
NCS1 neuronal calcium sensor 1
NFE2L3 nuclear factor, erythroid 2-like 3
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NUBP1 nucleotide binding protein 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARD6A par-6 family cell polarity regulator alpha
PARP16 poly (ADP-ribose) polymerase family, member 16
PILRB paired immunoglobin-like type 2 receptor beta
POLH polymerase (DNA directed), eta
PPL periplakin
PRR3 proline rich 3
PTX3 pentraxin 3, long
RAB3A RAB3A, member RAS oncogene family
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF121 ring finger protein 121
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROGDI rogdi homolog (Drosophila)
RPGR retinitis pigmentosa GTPase regulator
RPL23AP7 ribosomal protein L23a pseudogene 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETD1B SET domain containing 1B
SIX1 SIX homeobox 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SOX13 SRY (sex determining region Y)-box 13
STBD1 starch binding domain 1
STK16 serine/threonine kinase 16
STRN4 striatin, calmodulin binding protein 4
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TICAM1 toll-like receptor adaptor molecule 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLN1 talin 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC5 transmembrane channel-like 5
TMEM2 transmembrane protein 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
UBXN2B UBX domain protein 2B
WWC2 WW and C2 domain containing 2
XPC xeroderma pigmentosum, complementation group C
XYLT2 xylosyltransferase II
ZC3H3 zinc finger CCCH-type containing 3
ZNF426 zinc finger protein 426
ZNF552 zinc finger protein 552
ZNF813 zinc finger protein 813