diphenylpyraline-4299 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the diphenylpyraline-4299 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACOT11 acyl-CoA thioesterase 11
ACTN2 actinin, alpha 2
ACVR1B activin A receptor, type IB
ANGPTL2 angiopoietin-like 2
APAF1 apoptotic peptidase activating factor 1
ARHGAP35 Rho GTPase activating protein 35
ATP10A ATPase, class V, type 10A
B9D1 B9 protein domain 1
BEST2 bestrophin 2
BIRC7 baculoviral IAP repeat containing 7
C10ORF10 chromosome 10 open reading frame 10
C14ORF93 chromosome 14 open reading frame 93
C19ORF73 chromosome 19 open reading frame 73
CCDC170 coiled-coil domain containing 170
CD300A CD300a molecule
CD300C CD300c molecule
CDRT1 CMT1A duplicated region transcript 1
CETN1 centrin, EF-hand protein, 1
CFI complement factor I
CHD7 chromodomain helicase DNA binding protein 7
CLCN6 chloride channel, voltage-sensitive 6
CNTD2 cyclin N-terminal domain containing 2
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSPG4 chondroitin sulfate proteoglycan 4
CTIF CBP80/20-dependent translation initiation factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCAKD dephospho-CoA kinase domain containing
DENND3 DENN/MADD domain containing 3
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DSCAM Down syndrome cell adhesion molecule
DUSP7 dual specificity phosphatase 7
EFNB3 ephrin-B3
EPS8L1 EPS8-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAAH fatty acid amide hydrolase
FAM3A family with sequence similarity 3, member A
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GPR1 G protein-coupled receptor 1
GPR17 G protein-coupled receptor 17
GSTA3 glutathione S-transferase alpha 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOXA11 homeobox A11
HRG histidine-rich glycoprotein
IGKV1D-13 immunoglobulin kappa variable 1D-13
IGLJ3 immunoglobulin lambda joining 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP5J inositol polyphosphate-5-phosphatase J
IRF4 interferon regulatory factor 4
KIAA0040 KIAA0040
KIAA0232 KIAA0232
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLHL18 kelch-like family member 18
KRT86 keratin 86, type II
LAT2 linker for activation of T cells family, member 2
LEPR leptin receptor
LINC00115 long intergenic non-protein coding RNA 115
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRK1 leucine-rich repeat kinase 1
MAPK8 mitogen-activated protein kinase 8
MAU2 MAU2 sister chromatid cohesion factor
MED25 mediator complex subunit 25
MTSS1L metastasis suppressor 1-like
MVB12B multivesicular body subunit 12B
PAM peptidylglycine alpha-amidating monooxygenase
PCDHGA8 protocadherin gamma subfamily A, 8
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKP4 plakophilin 4
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLIN2 perilipin 2
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPRR protein tyrosine phosphatase, receptor type, R
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB6B RAB6B, member RAS oncogene family
RPL13P5 ribosomal protein L13 pseudogene 5
RPLP2 ribosomal protein, large, P2
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SNRK SNF related kinase
SPINK5 serine peptidase inhibitor, Kazal type 5
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STRA6 stimulated by retinoic acid 6
SUGP1 SURP and G patch domain containing 1
SYMPK symplekin
TBL1Y transducin (beta)-like 1, Y-linked
TBX2 T-box 2
TCF3 transcription factor 3
TNNT2 troponin T type 2 (cardiac)
TPM2 tropomyosin 2 (beta)
TSC22D2 TSC22 domain family, member 2
UBQLN4 ubiquilin 4
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APH1A APH1A gamma secretase subunit
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATAD5 ATPase family, AAA domain containing 5
BAX BCL2-associated X protein
C17ORF80 chromosome 17 open reading frame 80
CA9 carbonic anhydrase IX
CBX8 chromobox homolog 8
CD82 CD82 molecule
CDC37 cell division cycle 37
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHM choroideremia (Rab escort protein 1)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLEC2B C-type lectin domain family 2, member B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CORT cortistatin
CRIP2 cysteine-rich protein 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
EML4 echinoderm microtubule associated protein like 4
EPHX2 epoxide hydrolase 2, cytoplasmic
EXOC5 exocyst complex component 5
F2R coagulation factor II (thrombin) receptor
FAM186A family with sequence similarity 186, member A
FBRS fibrosin
FZD3 frizzled class receptor 3
FZD8 frizzled class receptor 8
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDE1 glycerophosphodiester phosphodiesterase 1
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GOLGA8B golgin A8 family, member B
GPHN gephyrin
GRPR gastrin-releasing peptide receptor
GTF2I general transcription factor IIi
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H1F0 H1 histone family, member 0
HOXB13 homeobox B13
HP1BP3 heterochromatin protein 1, binding protein 3
INCENP inner centromere protein antigens 135/155kDa
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KRI1 KRI1 homolog (S. cerevisiae)
LIG4 ligase IV, DNA, ATP-dependent
LPAR3 lysophosphatidic acid receptor 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCC mutated in colorectal cancers
METTL16 methyltransferase like 16
MPDU1 mannose-P-dolichol utilization defect 1
MPI mannose phosphate isomerase
NHEJ1 nonhomologous end-joining factor 1
NMD3 NMD3 ribosome export adaptor
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSMR oncostatin M receptor
PARPBP PARP1 binding protein
PDZK1 PDZ domain containing 1
PEX26 peroxisomal biogenesis factor 26
PGD phosphogluconate dehydrogenase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLXNB3 plexin B3
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKCD protein kinase C, delta
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PWAR5 Prader Willi/Angelman region RNA 5
RAB11B RAB11B, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RNF146 ring finger protein 146
SCYL2 SCY1-like 2 (S. cerevisiae)
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SPTBN2 spectrin, beta, non-erythrocytic 2
STIP1 stress-induced phosphoprotein 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SYTL2 synaptotagmin-like 2
TBC1D17 TBC1 domain family, member 17
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM230 transmembrane protein 230
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
WNT10B wingless-type MMTV integration site family, member 10B
YIPF5 Yip1 domain family, member 5
ZFYVE21 zinc finger, FYVE domain containing 21
ZMAT3 zinc finger, matrin-type 3
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF415 zinc finger protein 415
ZNF528 zinc finger protein 528
ZNF76 zinc finger protein 76