dinoprostone-6590 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dinoprostone-6590 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADCY2 adenylate cyclase 2 (brain)
ADCY7 adenylate cyclase 7
ALPK1 alpha-kinase 1
ASB9 ankyrin repeat and SOCS box containing 9
ATF6B activating transcription factor 6 beta
BAIAP2 BAI1-associated protein 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C16ORF45 chromosome 16 open reading frame 45
C17ORF53 chromosome 17 open reading frame 53
C2ORF27A chromosome 2 open reading frame 27A
CAMK1 calcium/calmodulin-dependent protein kinase I
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNO cyclin O
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNN1 calponin 1, basic, smooth muscle
CNOT4 CCR4-NOT transcription complex, subunit 4
CREBZF CREB/ATF bZIP transcription factor
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
GLS2 glutaminase 2 (liver, mitochondrial)
GPR153 G protein-coupled receptor 153
GSTA4 glutathione S-transferase alpha 4
GYG2 glycogenin 2
HCRP1 hepatocellular carcinoma-related HCRP1
HLA-F major histocompatibility complex, class I, F
HOXC8 homeobox C8
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL27RA interleukin 27 receptor, alpha
IL4R interleukin 4 receptor
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KAT5 K(lysine) acetyltransferase 5
LAT2 linker for activation of T cells family, member 2
LHX6 LIM homeobox 6
LINC00597 long intergenic non-protein coding RNA 597
LOC644450 uncharacterized LOC644450
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LUZP1 leucine zipper protein 1
MADD MAP-kinase activating death domain
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP1B microtubule-associated protein 1B
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MBTD1 mbt domain containing 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIIP migration and invasion inhibitory protein
MTRF1L mitochondrial translational release factor 1-like
NEK11 NIMA-related kinase 11
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NOP16 NOP16 nucleolar protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAPPA2 pappalysin 2
PCM1 pericentriolar material 1
PRMT7 protein arginine methyltransferase 7
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBM42 RNA binding motif protein 42
REC8 REC8 meiotic recombination protein
RIN1 Ras and Rab interactor 1
RNMT RNA (guanine-7-) methyltransferase
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RWDD3 RWD domain containing 3
SAFB scaffold attachment factor B
SAMD4A sterile alpha motif domain containing 4A
SCAF4 SR-related CTD-associated factor 4
SLC12A8 solute carrier family 12, member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG4 sperm associated antigen 4
ST20 suppressor of tumorigenicity 20
STK38L serine/threonine kinase 38 like
SYNGR1 synaptogyrin 1
TM7SF3 transmembrane 7 superfamily member 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TRIM25 tripartite motif containing 25
TRMT61A tRNA methyltransferase 61A
UBOX5 U-box domain containing 5
UBXN1 UBX domain protein 1
VEGFB vascular endothelial growth factor B
WBP4 WW domain binding protein 4
XAB2 XPA binding protein 2
ZER1 zyg-11 related, cell cycle regulator
ZNF174 zinc finger protein 174
ZNF552 zinc finger protein 552
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADM adrenomedullin
AES amino-terminal enhancer of split
APOLD1 apolipoprotein L domain containing 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BATF basic leucine zipper transcription factor, ATF-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BPGM 2,3-bisphosphoglycerate mutase
C1ORF159 chromosome 1 open reading frame 159
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD82 CD82 molecule
CHML choroideremia-like (Rab escort protein 2)
CLDND1 claudin domain containing 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
DCAF4 DDB1 and CUL4 associated factor 4
DDA1 DET1 and DDB1 associated 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAL4 dynein, axonemal, light chain 4
EFNA3 ephrin-A3
ERCC2 excision repair cross-complementation group 2
ERF Ets2 repressor factor
FAM86C1 family with sequence similarity 86, member C1
FBXL15 F-box and leucine-rich repeat protein 15
FKBP10 FK506 binding protein 10, 65 kDa
FNDC3B fibronectin type III domain containing 3B
GAB2 GRB2-associated binding protein 2
GALK1 galactokinase 1
GAMT guanidinoacetate N-methyltransferase
GRPR gastrin-releasing peptide receptor
GTPBP2 GTP binding protein 2
HHAT hedgehog acyltransferase
HIST1H2AI histone cluster 1, H2ai
HMGB3P1 high mobility group box 3 pseudogene 1
IDI2-AS1 IDI2 antisense RNA 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA0125 KIAA0125
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRSN2 neurensin 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PER1 period circadian clock 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAC1 placenta-specific 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PQLC2 PQ loop repeat containing 2
PTPRE protein tyrosine phosphatase, receptor type, E
RAB23 RAB23, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RNF146 ring finger protein 146
SAMHD1 SAM domain and HD domain 1
SAYSD1 SAYSVFN motif domain containing 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SHARPIN SHANK-associated RH domain interactor
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SRD5A3 steroid 5 alpha-reductase 3
STIM1 stromal interaction molecule 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TEP1 telomerase-associated protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
TMEM230 transmembrane protein 230
TMEM57 transmembrane protein 57
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D4 TSC22 domain family, member 4
TSPAN1 tetraspanin 1
TTPAL tocopherol (alpha) transfer protein-like
UNC119 unc-119 homolog (C. elegans)
USP36 ubiquitin specific peptidase 36
VAV1 vav 1 guanine nucleotide exchange factor
VGF VGF nerve growth factor inducible
WDR4 WD repeat domain 4
WDR76 WD repeat domain 76
ZBTB38 zinc finger and BTB domain containing 38
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF34 zinc finger protein 34
ZNF37BP zinc finger protein 37B, pseudogene
ZNF573 zinc finger protein 573
ZNHIT2 zinc finger, HIT-type containing 2