dinoprostone-6552 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dinoprostone-6552 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AR androgen receptor
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATAD5 ATPase family, AAA domain containing 5
ATF6 activating transcription factor 6
AURKA aurora kinase A
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C1ORF105 chromosome 1 open reading frame 105
CDK10 cyclin-dependent kinase 10
CGA glycoprotein hormones, alpha polypeptide
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSNK1A1 casein kinase 1, alpha 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHODH dihydroorotate dehydrogenase (quinone)
DMTN dematin actin binding protein
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSCR3 Down syndrome critical region 3
EAF2 ELL associated factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA3 ephrin-A3
FAM188A family with sequence similarity 188, member A
FEM1C fem-1 homolog c (C. elegans)
FERMT1 fermitin family member 1
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF23 fibroblast growth factor 23
FH fumarate hydratase
FLJ11292
FSTL3 follistatin-like 3 (secreted glycoprotein)
GCAT glycine C-acetyltransferase
GPR1 G protein-coupled receptor 1
HIST1H2AL histone cluster 1, H2al
HMGXB3 HMG box domain containing 3
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCE IQ motif containing E
KAZN kazrin, periplakin interacting protein
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLF5 Kruppel-like factor 5 (intestinal)
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRP2 low density lipoprotein receptor-related protein 2
LYST lysosomal trafficking regulator
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4 microtubule-associated protein 4
MAX MYC associated factor X
MED6 mediator complex subunit 6
MFAP3L microfibrillar-associated protein 3-like
MINK1 misshapen-like kinase 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO1E myosin IE
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD1 nucleotide-binding oligomerization domain containing 1
NUMA1 nuclear mitotic apparatus protein 1
PACS1 phosphofurin acidic cluster sorting protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGA8 protocadherin gamma subfamily A, 8
PHLDA3 pleckstrin homology-like domain, family A, member 3
PILRA paired immunoglobin-like type 2 receptor alpha
PLXNB1 plexin B1
PPP5C protein phosphatase 5, catalytic subunit
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKCE protein kinase C, epsilon
PRPF4B pre-mRNA processing factor 4B
PSEN1 presenilin 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB23 RAB23, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RBKS ribokinase
RBL1 retinoblastoma-like 1
REST RE1-silencing transcription factor
RHOQ ras homolog family member Q
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPL7 ribosomal protein L7
SCAPER S-phase cyclin A-associated protein in the ER
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIRPA signal-regulatory protein alpha
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
TEP1 telomerase-associated protein 1
TET3 tet methylcytosine dioxygenase 3
TFF2 trefoil factor 2
TMSB15A thymosin beta 15a
TNS2 tensin 2
TROVE2 TROVE domain family, member 2
TTBK2 tau tubulin kinase 2
UBQLN4 ubiquilin 4
UFSP2 UFM1-specific peptidase 2
VASP vasodilator-stimulated phosphoprotein
ZBTB1 zinc finger and BTB domain containing 1
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ALOX15 arachidonate 15-lipoxygenase
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
ATF7 activating transcription factor 7
BFSP1 beaded filament structural protein 1, filensin
BIRC7 baculoviral IAP repeat containing 7
C14ORF79 chromosome 14 open reading frame 79
C7ORF43 chromosome 7 open reading frame 43
CA10 carbonic anhydrase X
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD1A CD1a molecule
CES1 carboxylesterase 1
CLSTN2 calsyntenin 2
CUX2 cut-like homeobox 2
DAGLA diacylglycerol lipase, alpha
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPDC5 DEP domain containing 5
DGAT1 diacylglycerol O-acyltransferase 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
EHBP1L1 EH domain binding protein 1-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FLJ21369 uncharacterized protein FLJ21369
GADD45G growth arrest and DNA-damage-inducible, gamma
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GPATCH3 G patch domain containing 3
GPR157 G protein-coupled receptor 157
GPR19 G protein-coupled receptor 19
GPR20 G protein-coupled receptor 20
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRIP2 glutamate receptor interacting protein 2
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2BJ histone cluster 1, H2bj
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
IFI27 interferon, alpha-inducible protein 27
INPP1 inositol polyphosphate-1-phosphatase
JMJD4 jumonji domain containing 4
KDM8 lysine (K)-specific demethylase 8
KREMEN2 kringle containing transmembrane protein 2
LHX1 LIM homeobox 1
LINS lines homolog (Drosophila)
LOC100286895 cell division cycle 27 homolog pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
MBNL3 muscleblind-like splicing regulator 3
MFAP2 microfibrillar-associated protein 2
MXD3 MAX dimerization protein 3
NIPAL2 NIPA-like domain containing 2
NXF2 nuclear RNA export factor 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEAK1 pseudopodium-enriched atypical kinase 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
PMCH pro-melanin-concentrating hormone
POLM polymerase (DNA directed), mu
POU2F1 POU class 2 homeobox 1
PRAMEF12 PRAME family member 12
PRM1 protamine 1
PTK6 protein tyrosine kinase 6
PTPRU protein tyrosine phosphatase, receptor type, U
QPCTL glutaminyl-peptide cyclotransferase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RANGRF RAN guanine nucleotide release factor
RGS9 regulator of G-protein signaling 9
RHBDD3 rhomboid domain containing 3
RNF2 ring finger protein 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SALL2 spalt-like transcription factor 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH2B3 SH2B adaptor protein 3
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC30A3 solute carrier family 30 (zinc transporter), member 3
STX1A syntaxin 1A (brain)
SULT4A1 sulfotransferase family 4A, member 1
TBC1D17 TBC1 domain family, member 17
TDRD1 tudor domain containing 1
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM36 tripartite motif containing 36
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D4 TSC22 domain family, member 4
TSPAN1 tetraspanin 1
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC11 zinc finger, DHHC-type containing 11