dimenhydrinate-7431 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the dimenhydrinate-7431 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AR androgen receptor
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARNT aryl hydrocarbon receptor nuclear translocator
ASTN2 astrotactin 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BBS9 Bardet-Biedl syndrome 9
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CCDC93 coiled-coil domain containing 93
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CNGB3 cyclic nucleotide gated channel beta 3
COL5A1 collagen, type V, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CORT cortistatin
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DSTYK dual serine/threonine and tyrosine protein kinase
FADS2 fatty acid desaturase 2
FAM65A family with sequence similarity 65, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD7 frizzled class receptor 7
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLCE glucuronic acid epimerase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GYPB glycophorin B (MNS blood group)
HMHA1 histocompatibility (minor) HA-1
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
IRS2 insulin receptor substrate 2
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KDM6A lysine (K)-specific demethylase 6A
KLF2 Kruppel-like factor 2
KLHL26 kelch-like family member 26
KRT86 keratin 86, type II
LMNA lamin A/C
LOC730101 uncharacterized LOC730101
LONP2 lon peptidase 2, peroxisomal
MAST3 microtubule associated serine/threonine kinase 3
MFAP3 microfibrillar-associated protein 3
MIER2 mesoderm induction early response 1, family member 2
MOCS1 molybdenum cofactor synthesis 1
MPDZ multiple PDZ domain protein
MVB12B multivesicular body subunit 12B
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
PARVB parvin, beta
PCDHB8 protocadherin beta 8
PCM1 pericentriolar material 1
PDCD2 programmed cell death 2
PEX5 peroxisomal biogenesis factor 5
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRB paired immunoglobin-like type 2 receptor beta
PRKCI protein kinase C, iota
PRLR prolactin receptor
PRMT2 protein arginine methyltransferase 2
PTPRA protein tyrosine phosphatase, receptor type, A
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB33B RAB33B, member RAS oncogene family
RAD51B RAD51 paralog B
RIPK4 receptor-interacting serine-threonine kinase 4
RND2 Rho family GTPase 2
RNF6 ring finger protein (C3H2C3 type) 6
RNFT2 ring finger protein, transmembrane 2
S100A8 S100 calcium binding protein A8
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNN stannin
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST20 suppressor of tumorigenicity 20
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TDRD1 tudor domain containing 1
TLE4 transducin-like enhancer of split 4
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
UBAP1 ubiquitin associated protein 1
WDR48 WD repeat domain 48
WDR59 WD repeat domain 59
ZER1 zyg-11 related, cell cycle regulator
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADAM15 ADAM metallopeptidase domain 15
AFAP1 actin filament associated protein 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATAD5 ATPase family, AAA domain containing 5
ATF7IP2 activating transcription factor 7 interacting protein 2
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
C11ORF68 chromosome 11 open reading frame 68
C14ORF132 chromosome 14 open reading frame 132
CAPN5 calpain 5
CBR3 carbonyl reductase 3
CCP110 centriolar coiled coil protein 110kDa
CLSPN claspin
COCH cochlin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRYL1 crystallin, lambda 1
DENND4A DENN/MADD domain containing 4A
DGKZ diacylglycerol kinase, zeta
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DOCK1 dedicator of cytokinesis 1
DYSF dysferlin
ECH1 enoyl CoA hydratase 1, peroxisomal
EPHA2 EPH receptor A2
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM189A2 family with sequence similarity 189, member A2
FAM53B family with sequence similarity 53, member B
FAM86C1 family with sequence similarity 86, member C1
FBXO46 F-box protein 46
FRK fyn-related Src family tyrosine kinase
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FUZ fuzzy planar cell polarity protein
FZD4 frizzled class receptor 4
GMIP GEM interacting protein
GNL1 guanine nucleotide binding protein-like 1
GRB7 growth factor receptor-bound protein 7
GTPBP6 GTP binding protein 6 (putative)
HIST1H2BI histone cluster 1, H2bi
IP6K1 inositol hexakisphosphate kinase 1
IPO8 importin 8
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KREMEN2 kringle containing transmembrane protein 2
LINS lines homolog (Drosophila)
LOC100287590 uncharacterized LOC100287590
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC61 leucine rich repeat containing 61
MARC1 mitochondrial amidoxime reducing component 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCOLN1 mucolipin 1
MED22 mediator complex subunit 22
MFSD11 major facilitator superfamily domain containing 11
MOCS3 molybdenum cofactor synthesis 3
MUM1 melanoma associated antigen (mutated) 1
MYO1E myosin IE
NFE2L3 nuclear factor, erythroid 2-like 3
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY5R neuropeptide Y receptor Y5
ONECUT2 one cut homeobox 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHB3 protocadherin beta 3
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMP22 peripheral myelin protein 22
POLI polymerase (DNA directed) iota
PPCDC phosphopantothenoylcysteine decarboxylase
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB17 RAB17, member RAS oncogene family
RAD54L RAD54-like (S. cerevisiae)
RANBP17 RAN binding protein 17
RANGRF RAN guanine nucleotide release factor
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL13P5 ribosomal protein L13 pseudogene 5
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRAS related RAS viral (r-ras) oncogene homolog
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A9 solute carrier family 12, member 9
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SOX12 SRY (sex determining region Y)-box 12
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TAOK1 TAO kinase 1
TBC1D17 TBC1 domain family, member 17
TCTN1 tectonic family member 1
TESK2 testis-specific kinase 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TSC22D4 TSC22 domain family, member 4
TSPYL2 TSPY-like 2
TUBA4A tubulin, alpha 4a
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
VAX2 ventral anterior homeobox 2
VEGFB vascular endothelial growth factor B
WDR60 WD repeat domain 60
YIPF1 Yip1 domain family, member 1
ZNF205 zinc finger protein 205
ZNF286A zinc finger protein 286A
ZNF74 zinc finger protein 74
ZNHIT2 zinc finger, HIT-type containing 2