diltiazem-6710 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the diltiazem-6710 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRE3 adhesion G protein-coupled receptor E3
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKR1C2 aldo-keto reductase family 1, member C2
ARL14 ADP-ribosylation factor-like 14
C5AR1 complement component 5a receptor 1
C5ORF42 chromosome 5 open reading frame 42
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL22 chemokine (C-C motif) ligand 22
CD209 CD209 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLCA2 chloride channel accessory 2
COMT catechol-O-methyltransferase
CTH cystathionine gamma-lyase
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
CYSLTR1 cysteinyl leukotriene receptor 1
DICER1 dicer 1, ribonuclease type III
DMBT1 deleted in malignant brain tumors 1
DUX4L8 double homeobox 4 like 8
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFCAB11 EF-hand calcium binding domain 11
EMID1 EMI domain containing 1
ESR1 estrogen receptor 1
FAM149A family with sequence similarity 149, member A
FOXO4 forkhead box O4
GADD45G growth arrest and DNA-damage-inducible, gamma
GAN gigaxonin
GAS7 growth arrest-specific 7
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR35 G protein-coupled receptor 35
GRM8 glutamate receptor, metabotropic 8
GZMK granzyme K (granzyme 3; tryptase II)
HEMK1 HemK methyltransferase family member 1
HIST1H2AL histone cluster 1, H2al
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IL11 interleukin 11
IL6 interleukin 6
INPP5J inositol polyphosphate-5-phosphatase J
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIDINS220 kinase D-interacting substrate, 220kDa
KLK13 kallikrein-related peptidase 13
KRT14 keratin 14, type I
KRTAP2-4 keratin associated protein 2-4
MAP7 microtubule-associated protein 7
MEGF6 multiple EGF-like-domains 6
MFAP3L microfibrillar-associated protein 3-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTMR7 myotubularin related protein 7
MUC2 mucin 2, oligomeric mucus/gel-forming
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NOX1 NADPH oxidase 1
NUP88 nucleoporin 88kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAZ3 ornithine decarboxylase antizyme 3
OCM2 oncomodulin 2
PADI1 peptidyl arginine deiminase, type I
PDE10A phosphodiesterase 10A
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLXNB3 plexin B3
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRDM12 PR domain containing 12
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRTN3 proteinase 3
PTGES prostaglandin E synthase
PTPN1 protein tyrosine phosphatase, non-receptor type 1
QPCTL glutaminyl-peptide cyclotransferase-like
REG1P regenerating islet-derived 1 pseudogene
RIMS2 regulating synaptic membrane exocytosis 2
RPH3AL rabphilin 3A-like (without C2 domains)
RPL14 ribosomal protein L14
RPLP2 ribosomal protein, large, P2
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SCN1B sodium channel, voltage gated, type I beta subunit
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOSTDC1 sclerostin domain containing 1
SOX2 SRY (sex determining region Y)-box 2
SPTBN5 spectrin, beta, non-erythrocytic 5
STC1 stanniocalcin 1
SUGP1 SURP and G patch domain containing 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TDRD12 tudor domain containing 12
TSKS testis-specific serine kinase substrate
UBE2I ubiquitin-conjugating enzyme E2I
XAF1 XIAP associated factor 1
ZNF446 zinc finger protein 446
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADAT1 adenosine deaminase, tRNA-specific 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BEX4 brain expressed, X-linked 4
BGLAP bone gamma-carboxyglutamate (gla) protein
C19ORF40 chromosome 19 open reading frame 40
CA5BP1 carbonic anhydrase VB pseudogene 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CDC37L1 cell division cycle 37-like 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDCA3 cell division cycle associated 3
CHM choroideremia (Rab escort protein 1)
CLDN4 claudin 4
CLPTM1 cleft lip and palate associated transmembrane protein 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMP3 epithelial membrane protein 3
ERF Ets2 repressor factor
FAM53B family with sequence similarity 53, member B
FAT4 FAT atypical cadherin 4
FBXL6 F-box and leucine-rich repeat protein 6
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FNTB farnesyltransferase, CAAX box, beta
GALK1 galactokinase 1
GCHFR GTP cyclohydrolase I feedback regulator
GDAP1 ganglioside induced differentiation associated protein 1
GLOD4 glyoxalase domain containing 4
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR176 G protein-coupled receptor 176
GTF2I general transcription factor IIi
H2BFS H2B histone family, member S (pseudogene)
HIST1H1E histone cluster 1, H1e
HIST1H2AM histone cluster 1, H2am
HIST1H4E histone cluster 1, H4e
HMOX1 heme oxygenase 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KIAA0922 KIAA0922
KIAA1462 KIAA1462
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100127972 uncharacterized LOC100127972
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECR mitochondrial trans-2-enoyl-CoA reductase
MMP13 matrix metallopeptidase 13
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MT1HL1 metallothionein 1H-like 1
MT2A metallothionein 2A
MYL5 myosin, light chain 5, regulatory
NCAPH non-SMC condensin I complex, subunit H
NDRG4 NDRG family member 4
NRSN2 neurensin 2
NUBP2 nucleotide binding protein 2
OLFML3 olfactomedin-like 3
OSMR oncostatin M receptor
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PALMD palmdelphin
PAX9 paired box 9
PDCD5 programmed cell death 5
PGD phosphogluconate dehydrogenase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PMVK phosphomevalonate kinase
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRICKLE3 prickle homolog 3 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTK7 protein tyrosine kinase 7 (inactive)
RAB5B RAB5B, member RAS oncogene family
RARS arginyl-tRNA synthetase
RPL11 ribosomal protein L11
SCAMP5 secretory carrier membrane protein 5
SELT selenoprotein T
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLPI secretory leukocyte peptidase inhibitor
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TH tyrosine hydroxylase
TMEM242 transmembrane protein 242
TRAPPC2L trafficking protein particle complex 2-like
TRIM16 tripartite motif containing 16
TRIM25 tripartite motif containing 25
TXLNG taxilin gamma
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZMAT5 zinc finger, matrin-type 5
ZNF227 zinc finger protein 227
ZNF385D zinc finger protein 385D