diltiazem-2032 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the diltiazem-2032 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACVRL1 activin A receptor type II-like 1
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
ARNT aryl hydrocarbon receptor nuclear translocator
ATG4B autophagy related 4B, cysteine peptidase
ATN1 atrophin 1
C22ORF24 chromosome 22 open reading frame 24
CCDC40 coiled-coil domain containing 40
CDK13 cyclin-dependent kinase 13
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CLDN10 claudin 10
COL10A1 collagen, type X, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CREM cAMP responsive element modulator
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DDAH2 dimethylarginine dimethylaminohydrolase 2
DGCR8 DGCR8 microprocessor complex subunit
DSCR3 Down syndrome critical region 3
EFR3B EFR3 homolog B (S. cerevisiae)
ELMO2 engulfment and cell motility 2
EPHB2 EPH receptor B2
EPS8L1 EPS8-like 1
EXD3 exonuclease 3'-5' domain containing 3
EXTL3 exostosin-like glycosyltransferase 3
FBXO42 F-box protein 42
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FSCN1 fascin actin-bundling protein 1
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNL1 guanine nucleotide binding protein-like 1
GPR107 G protein-coupled receptor 107
GPX2 glutathione peroxidase 2
HIST1H2BI histone cluster 1, H2bi
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNF1A HNF1 homeobox A
HOXB5 homeobox B5
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTRA1 HtrA serine peptidase 1
IFNA17 interferon, alpha 17
IFT27 intraflagellar transport 27
IGF1R insulin-like growth factor 1 receptor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLHL12 kelch-like family member 12
LAD1 ladinin 1
LENEP lens epithelial protein
LTB4R leukotriene B4 receptor
LUZP1 leucine zipper protein 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAX MYC associated factor X
MED16 mediator complex subunit 16
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MPZ myelin protein zero
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NADK NAD kinase
NOTCH2 notch 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NXF2 nuclear RNA export factor 2
OCRL oculocerebrorenal syndrome of Lowe
PALM paralemmin
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PECAM1 platelet/endothelial cell adhesion molecule 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLEC plectin
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRSS22 protease, serine, 22
PRSS53 protease, serine, 53
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRU protein tyrosine phosphatase, receptor type, U
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RGS1 regulator of G-protein signaling 1
RORC RAR-related orphan receptor C
RPS11 ribosomal protein S11
SENP5 SUMO1/sentrin specific peptidase 5
SEZ6L seizure related 6 homolog (mouse)-like
SFTPB surfactant protein B
SH2D1A SH2 domain containing 1A
SH3BP2 SH3-domain binding protein 2
SIGLEC5 sialic acid binding Ig-like lectin 5
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNTA1 syntrophin, alpha 1
STAT2 signal transducer and activator of transcription 2, 113kDa
SYT2 synaptotagmin II
TBL1X transducin (beta)-like 1X-linked
TRPV1 transient receptor potential cation channel, subfamily V, member 1
WIZ widely interspaced zinc finger motifs
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZGPAT zinc finger, CCCH-type with G patch domain
ZNF211 zinc finger protein 211
ZNF79 zinc finger protein 79
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AVEN apoptosis, caspase activation inhibitor
AZI2 5-azacytidine induced 2
C12ORF29 chromosome 12 open reading frame 29
C1D C1D nuclear receptor corepressor
C1ORF54 chromosome 1 open reading frame 54
CCDC6 coiled-coil domain containing 6
CD302 CD302 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP72 centrosomal protein 72kDa
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COCH cochlin
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COMMD8 COMM domain containing 8
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CPOX coproporphyrinogen oxidase
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CYB5R3 cytochrome b5 reductase 3
DENND1B DENN/MADD domain containing 1B
DNAAF2 dynein, axonemal, assembly factor 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DVL1 dishevelled segment polarity protein 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EMP3 epithelial membrane protein 3
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FAM222B family with sequence similarity 222, member B
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCHSD2 FCH and double SH3 domains 2
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GLOD4 glyoxalase domain containing 4
GMEB1 glucocorticoid modulatory element binding protein 1
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPN3 GPN-loop GTPase 3
GRWD1 glutamate-rich WD repeat containing 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIRA histone cell cycle regulator
HSPA4L heat shock 70kDa protein 4-like
ITGAV integrin, alpha V
JMJD4 jumonji domain containing 4
KIF20B kinesin family member 20B
KIFC1 kinesin family member C1
KTN1 kinectin 1 (kinesin receptor)
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LSM1 LSM1, U6 small nuclear RNA associated
LYRM2 LYR motif containing 2
MAEA macrophage erythroblast attacher
MAPK3 mitogen-activated protein kinase 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL18 methyltransferase like 18
MT1HL1 metallothionein 1H-like 1
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFE2L2 nuclear factor, erythroid 2-like 2
NOL6 nucleolar protein 6 (RNA-associated)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
ORC2 origin recognition complex, subunit 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAQR3 progestin and adipoQ receptor family member III
PBK PDZ binding kinase
PEMT phosphatidylethanolamine N-methyltransferase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PNRC1 proline-rich nuclear receptor coactivator 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POTEKP POTE ankyrin domain family, member K, pseudogene
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RARS arginyl-tRNA synthetase
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RIOK2 RIO kinase 2
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RWDD3 RWD domain containing 3
SERINC1 serine incorporator 1
SMNDC1 survival motor neuron domain containing 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SREBF1 sterol regulatory element binding transcription factor 1
STEAP3 STEAP family member 3, metalloreductase
STK39 serine threonine kinase 39
TIPIN TIMELESS interacting protein
TMEM14A transmembrane protein 14A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM168 transmembrane protein 168
TPCN1 two pore segment channel 1
TRAPPC11 trafficking protein particle complex 11
TUBA1A tubulin, alpha 1a
UBE3C ubiquitin protein ligase E3C
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF12 zinc finger protein 12
ZNF14 zinc finger protein 14
ZNF217 zinc finger protein 217
ZNF652 zinc finger protein 652
ZNF654 zinc finger protein 654
ZW10 zw10 kinetochore protein