dihydroergotamine-6840 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the dihydroergotamine-6840 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ADCK2 aarF domain containing kinase 2
ADGRG1 adhesion G protein-coupled receptor G1
ADRBK1 adrenergic, beta, receptor kinase 1
AMH anti-Mullerian hormone
ANKRD55 ankyrin repeat domain 55
ARHGAP26 Rho GTPase activating protein 26
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BEGAIN brain-enriched guanylate kinase-associated
C11ORF16 chromosome 11 open reading frame 16
C1QTNF1 C1q and tumor necrosis factor related protein 1
CA5B carbonic anhydrase VB, mitochondrial
CALML5 calmodulin-like 5
CD34 CD34 molecule
CFAP70 cilia and flagella associated protein 70
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLUAP1 clusterin associated protein 1
COL11A1 collagen, type XI, alpha 1
COL19A1 collagen, type XIX, alpha 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EGFR epidermal growth factor receptor
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERCC2 excision repair cross-complementation group 2
FAM149A family with sequence similarity 149, member A
FAM155A family with sequence similarity 155, member A
FAM214B family with sequence similarity 214, member B
FBN2 fibrillin 2
FBXL7 F-box and leucine-rich repeat protein 7
FBXO40 F-box protein 40
FGF2 fibroblast growth factor 2 (basic)
GPR15 G protein-coupled receptor 15
GRM2 glutamate receptor, metabotropic 2
HFE hemochromatosis
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNMT histamine N-methyltransferase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHA1 immunoglobulin heavy constant alpha 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL5RA interleukin 5 receptor, alpha
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
LAMA4 laminin, alpha 4
LRRC48 leucine rich repeat containing 48
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK14 mitogen-activated protein kinase 14
MC3R melanocortin 3 receptor
MYH14 myosin, heavy chain 14, non-muscle
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD2 nucleotide-binding oligomerization domain containing 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFML2B olfactomedin-like 2B
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE9A phosphodiesterase 9A
PDLIM3 PDZ and LIM domain 3
PILRA paired immunoglobin-like type 2 receptor alpha
PLCD1 phospholipase C, delta 1
PLK3 polo-like kinase 3
PPARD peroxisome proliferator-activated receptor delta
PPP1R37 protein phosphatase 1, regulatory subunit 37
RAI2 retinoic acid induced 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFPL3 ret finger protein-like 3
RPH3A rabphilin 3A
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPDEF SAM pointed domain containing ETS transcription factor
SRCAP Snf2-related CREBBP activator protein
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
TAOK2 TAO kinase 2
TCP11L1 t-complex 11, testis-specific-like 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPMT thiopurine S-methyltransferase
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
TUBA3C tubulin, alpha 3c
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VIPR2 vasoactive intestinal peptide receptor 2
WNT16 wingless-type MMTV integration site family, member 16
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF3 zinc finger protein 3
ZNF532 zinc finger protein 532
ZNF710 zinc finger protein 710
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADCY6 adenylate cyclase 6
ALS2CL ALS2 C-terminal like
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKRD40 ankyrin repeat domain 40
ARPIN actin-related protein 2/3 complex inhibitor
AUTS2 autism susceptibility candidate 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTF3P11 basic transcription factor 3 pseudogene 11
CAPN5 calpain 5
CD82 CD82 molecule
CIDEC cell death-inducing DFFA-like effector c
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CORO7 coronin 7
CRIP1 cysteine-rich protein 1 (intestinal)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DEAF1 DEAF1 transcription factor
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSCAM Down syndrome cell adhesion molecule
EGFL7 EGF-like-domain, multiple 7
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXD3 exonuclease 3'-5' domain containing 3
FBXO22 F-box protein 22
FKBP10 FK506 binding protein 10, 65 kDa
FOXI1 forkhead box I1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTA4 glutathione S-transferase alpha 4
GTPBP2 GTP binding protein 2
HDAC7 histone deacetylase 7
HMOX1 heme oxygenase 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL20RA interleukin 20 receptor, alpha
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
KIAA0125 KIAA0125
KIAA0319L KIAA0319-like
LAMP3 lysosomal-associated membrane protein 3
LOC100286895 cell division cycle 27 homolog pseudogene
MED15 mediator complex subunit 15
METTL16 methyltransferase like 16
MORC3 MORC family CW-type zinc finger 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL52 mitochondrial ribosomal protein L52
NABP2 nucleic acid binding protein 2
NCALD neurocalcin delta
NES nestin
NKAIN1 Na+/K+ transporting ATPase interacting 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PADI3 peptidyl arginine deiminase, type III
PAQR6 progestin and adipoQ receptor family member VI
PCBP4 poly(rC) binding protein 4
PCDHB13 protocadherin beta 13
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PP14571 uncharacterized LOC100130449
PRF1 perforin 1 (pore forming protein)
QPCTL glutaminyl-peptide cyclotransferase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB8B RAB8B, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RGS2 regulator of G-protein signaling 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF121 ring finger protein 121
RPL13P5 ribosomal protein L13 pseudogene 5
SCN1B sodium channel, voltage gated, type I beta subunit
SCRN3 secernin 3
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
TGFBR1 transforming growth factor, beta receptor 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM212 transmembrane protein 212
TMEM53 transmembrane protein 53
TMPRSS2 transmembrane protease, serine 2
TMSB15A thymosin beta 15a
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM21 tripartite motif containing 21
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBG2 tubulin, gamma 2
TWISTNB TWIST neighbor
USB1 U6 snRNA biogenesis 1
XAB2 XPA binding protein 2
ZFP30 ZFP30 zinc finger protein
ZNF34 zinc finger protein 34
ZNF747 zinc finger protein 747