dihydroergotamine-4502 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the dihydroergotamine-4502 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARID1A AT rich interactive domain 1A (SWI-like)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCAS1 breast carcinoma amplified sequence 1
C8B complement component 8, beta polypeptide
CA5B carbonic anhydrase VB, mitochondrial
CD68 CD68 molecule
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP41 centrosomal protein 41kDa
CERS4 ceramide synthase 4
CLCA1 chloride channel accessory 1
CLCN7 chloride channel, voltage-sensitive 7
CLEC11A C-type lectin domain family 11, member A
CNOT2 CCR4-NOT transcription complex, subunit 2
COL9A3 collagen, type IX, alpha 3
CORO2B coronin, actin binding protein, 2B
CUZD1 CUB and zona pellucida-like domains 1
DMC1 DNA meiotic recombinase 1
ECE1 endothelin converting enzyme 1
EGFL7 EGF-like-domain, multiple 7
ELOVL2 ELOVL fatty acid elongase 2
EXOSC2 exosome component 2
FAM134B family with sequence similarity 134, member B
FRS3 fibroblast growth factor receptor substrate 3
GADD45B growth arrest and DNA-damage-inducible, beta
GJA8 gap junction protein, alpha 8, 50kDa
GLP1R glucagon-like peptide 1 receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSN-AS1 GSN antisense RNA 1
HHAT hedgehog acyltransferase
HPX hemopexin
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSF2BP heat shock transcription factor 2 binding protein
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ICA1 islet cell autoantigen 1, 69kDa
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R2 interleukin 1 receptor, type II
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCTD17 potassium channel tetramerization domain containing 17
KDM5B lysine (K)-specific demethylase 5B
KRT19P2 keratin 19 pseudogene 2
LDAH lipid droplet associated hydrolase
LRP2 low density lipoprotein receptor-related protein 2
LRRC17 leucine rich repeat containing 17
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFAP3L microfibrillar-associated protein 3-like
MMP25 matrix metallopeptidase 25
MYH14 myosin, heavy chain 14, non-muscle
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCOR2 nuclear receptor corepressor 2
NPR2 natriuretic peptide receptor 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRXN3 neurexin 3
OLFM1 olfactomedin 1
OR7C1 olfactory receptor, family 7, subfamily C, member 1
OXCT2 3-oxoacid CoA transferase 2
PAPPA2 pappalysin 2
PAX4 paired box 4
PRB4 proline-rich protein BstNI subfamily 4
PRDM1 PR domain containing 1, with ZNF domain
PRKCDBP protein kinase C, delta binding protein
PTCH1 patched 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB36 RAB36, member RAS oncogene family
RAD51B RAD51 paralog B
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
REC8 REC8 meiotic recombination protein
RIN3 Ras and Rab interactor 3
ROPN1B rhophilin associated tail protein 1B
SCN10A sodium channel, voltage gated, type X alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERHL2 serine hydrolase-like 2
SFTPB surfactant protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC6A16 solute carrier family 6, member 16
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOX15 SRY (sex determining region Y)-box 15
SSX3 synovial sarcoma, X breakpoint 3
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STOML1 stomatin (EPB72)-like 1
TAS2R10 taste receptor, type 2, member 10
TBCD tubulin folding cofactor D
TBX5 T-box 5
TCEAL2 transcription elongation factor A (SII)-like 2
THTPA thiamine triphosphatase
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53I11 tumor protein p53 inducible protein 11
TRA T cell receptor alpha locus
TRIM10 tripartite motif containing 10
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTLL4 tubulin tyrosine ligase-like family member 4
ZNF528 zinc finger protein 528

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAT1 adenosine deaminase, tRNA-specific 1
ADGRB2 adhesion G protein-coupled receptor B2
ANOS1 anosmin 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BBC3 BCL2 binding component 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
C6ORF47 chromosome 6 open reading frame 47
CCL27 chemokine (C-C motif) ligand 27
CCNL2 cyclin L2
CD101 CD101 molecule
CDHR2 cadherin-related family member 2
CEP295 centrosomal protein 295kDa
CHML choroideremia-like (Rab escort protein 2)
CLDN8 claudin 8
CTSF cathepsin F
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DIXDC1 DIX domain containing 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM118A family with sequence similarity 118, member A
FBXO2 F-box protein 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR176 G protein-coupled receptor 176
GTF2I general transcription factor IIi
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIRA histone cell cycle regulator
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA1 homeobox A1
HYAL3 hyaluronoglucosaminidase 3
IL17RA interleukin 17 receptor A
IMPACT impact RWD domain protein
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
LINS lines homolog (Drosophila)
LMO7 LIM domain 7
LRRK1 leucine-rich repeat kinase 1
MOXD1 monooxygenase, DBH-like 1
NABP1 nucleic acid binding protein 1
NARFL nuclear prelamin A recognition factor-like
NAT6 N-acetyltransferase 6 (GCN5-related)
NEK11 NIMA-related kinase 11
NOL6 nucleolar protein 6 (RNA-associated)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSMR oncostatin M receptor
OTUD3 OTU deubiquitinase 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PER3 period circadian clock 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKN1 protein kinase N1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PTK7 protein tyrosine kinase 7 (inactive)
RAB5B RAB5B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAP1GAP2 RAP1 GTPase activating protein 2
RECQL4 RecQ protein-like 4
RNF122 ring finger protein 122
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCYL2 SCY1-like 2 (S. cerevisiae)
SELL selectin L
SH2D4A SH2 domain containing 4A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC12A8 solute carrier family 12, member 8
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC46A3 solute carrier family 46, member 3
SP1 Sp1 transcription factor
SPTBN2 spectrin, beta, non-erythrocytic 2
SRD5A3 steroid 5 alpha-reductase 3
TMEM120B transmembrane protein 120B
TMEM53 transmembrane protein 53
TNS2 tensin 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YY2 YY2 transcription factor
ZNF134 zinc finger protein 134
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF442 zinc finger protein 442
ZNF702P zinc finger protein 702, pseudogene
ZNF711 zinc finger protein 711
ZNF768 zinc finger protein 768
ZNHIT2 zinc finger, HIT-type containing 2