dihydroergotamine-2244 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the dihydroergotamine-2244 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM12 ADAM metallopeptidase domain 12
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AUTS2 autism susceptibility candidate 2
BDKRB2 bradykinin receptor B2
BLNK B-cell linker
C19ORF66 chromosome 19 open reading frame 66
C1ORF95 chromosome 1 open reading frame 95
C4BPA complement component 4 binding protein, alpha
C7ORF69 chromosome 7 open reading frame 69
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CADM3 cell adhesion molecule 3
CD48 CD48 molecule
CFAP70 cilia and flagella associated protein 70
CGA glycoprotein hormones, alpha polypeptide
CLIC2 chloride intracellular channel 2
CLTA clathrin, light chain A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DOPEY2 dopey family member 2
DRD2 dopamine receptor D2
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFS embryonal Fyn-associated substrate
ELF5 E74-like factor 5 (ets domain transcription factor)
FKRP fukutin related protein
GATA1 GATA binding protein 1 (globin transcription factor 1)
GBP1 guanylate binding protein 1, interferon-inducible
GRK5 G protein-coupled receptor kinase 5
GTPBP1 GTP binding protein 1
HBE1 hemoglobin, epsilon 1
HDAC7 histone deacetylase 7
HDLBP high density lipoprotein binding protein
HEG1 heart development protein with EGF-like domains 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICOSLG inducible T-cell co-stimulator ligand
IL11 interleukin 11
IL12B interleukin 12B
INSL4 insulin-like 4 (placenta)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF13 Kruppel-like factor 13
KLHL1 kelch-like family member 1
KLHL29 kelch-like family member 29
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LTBP2 latent transforming growth factor beta binding protein 2
MAOA monoamine oxidase A
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIER2 mesoderm induction early response 1, family member 2
MVB12B multivesicular body subunit 12B
MYF5 myogenic factor 5
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCAPH2 non-SMC condensin II complex, subunit H2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NF2 neurofibromin 2 (merlin)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
ONECUT2 one cut homeobox 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDIA2 protein disulfide isomerase family A, member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLM polymerase (DNA directed), mu
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRDX2 peroxiredoxin 2
PTCRA pre T-cell antigen receptor alpha
PVR poliovirus receptor
RND1 Rho family GTPase 1
RPLP2 ribosomal protein, large, P2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SAMD9 sterile alpha motif domain containing 9
SARM1 sterile alpha and TIR motif containing 1
SERHL2 serine hydrolase-like 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLIT1 slit homolog 1 (Drosophila)
SMAD1 SMAD family member 1
SOX12 SRY (sex determining region Y)-box 12
SOX30 SRY (sex determining region Y)-box 30
SP4 Sp4 transcription factor
SPAG8 sperm associated antigen 8
SPEG SPEG complex locus
SPRY4 sprouty homolog 4 (Drosophila)
SRPR signal recognition particle receptor (docking protein)
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBC1D2 TBC1 domain family, member 2
TBCD tubulin folding cofactor D
TRAF3IP3 TRAF3 interacting protein 3
TRD T cell receptor delta locus
UPK2 uroplakin 2
USP12 ubiquitin specific peptidase 12
VEZT vezatin, adherens junctions transmembrane protein
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOD apolipoprotein D
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BBC3 BCL2 binding component 3
BMP4 bone morphogenetic protein 4
C11ORF63 chromosome 11 open reading frame 63
C1ORF105 chromosome 1 open reading frame 105
C9ORF9 chromosome 9 open reading frame 9
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC9 coiled-coil domain containing 9
CCNL2 cyclin L2
CDK3 cyclin-dependent kinase 3
CEL carboxyl ester lipase
CHML choroideremia-like (Rab escort protein 2)
CIC capicua transcriptional repressor
CRELD1 cysteine-rich with EGF-like domains 1
CRY2 cryptochrome circadian clock 2
CST6 cystatin E/M
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF10 DDB1 and CUL4 associated factor 10
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DSCAM Down syndrome cell adhesion molecule
DTX2 deltex 2, E3 ubiquitin ligase
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ETAA1 Ewing tumor-associated antigen 1
EXD3 exonuclease 3'-5' domain containing 3
FAM110B family with sequence similarity 110, member B
FAM204A family with sequence similarity 204, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FFAR2 free fatty acid receptor 2
FLJ11710 uncharacterized protein FLJ11710
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR143 G protein-coupled receptor 143
GSTM5 glutathione S-transferase mu 5
HDAC5 histone deacetylase 5
HIST1H3E histone cluster 1, H3e
HPN hepsin
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI35 interferon-induced protein 35
IPO8 importin 8
KIAA0894 KIAA0894 protein
LAMP3 lysosomal-associated membrane protein 3
LIME1 Lck interacting transmembrane adaptor 1
LINC00597 long intergenic non-protein coding RNA 597
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRPL41 mitochondrial ribosomal protein L41
MT1H metallothionein 1H
MVP major vault protein
MYOZ1 myozenin 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PGP phosphoglycolate phosphatase
PICK1 protein interacting with PRKCA 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLD2 phospholipase D2
PROS1 protein S (alpha)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB30 RAB30, member RAS oncogene family
RCAN3 RCAN family member 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF208 ring finger protein 208
RPAIN RPA interacting protein
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SAYSD1 SAYSVFN motif domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLIT2 slit homolog 2 (Drosophila)
SLMO1 slowmo homolog 1 (Drosophila)
STARD3 StAR-related lipid transfer (START) domain containing 3
STRA6 stimulated by retinoic acid 6
TBC1D17 TBC1 domain family, member 17
TBX19 T-box 19
TFF2 trefoil factor 2
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR2 toll-like receptor 2
TMC7 transmembrane channel-like 7
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM21 tripartite motif containing 21
TTC23 tetratricopeptide repeat domain 23
VEGFC vascular endothelial growth factor C
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZNF16 zinc finger protein 16
ZNF286A zinc finger protein 286A
ZNF350 zinc finger protein 350
ZNF574 zinc finger protein 574