digoxin-2423 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the digoxin-2423 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRB3 adrenoceptor beta 3
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BTBD18 BTB (POZ) domain containing 18
BTG2 BTG family, member 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C18ORF25 chromosome 18 open reading frame 25
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD83 CD83 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CLEC4A C-type lectin domain family 4, member A
CREM cAMP responsive element modulator
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
EED embryonic ectoderm development
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EPHA4 EPH receptor A4
FCAR Fc fragment of IgA receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL24 interleukin 24
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MORN1 MORN repeat containing 1
MTF1 metal-regulatory transcription factor 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM1 olfactomedin 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PLP1 proteolipid protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
RUNX1 runt-related transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SMC4 structural maintenance of chromosomes 4
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS1 son of sevenless homolog 1 (Drosophila)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM2D1 TM2 domain containing 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB2 transducer of ERBB2, 2
TRIB1 tribbles pseudokinase 1
TRIM38 tripartite motif containing 38
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UBXN1 UBX domain protein 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZBTB40 zinc finger and BTB domain containing 40
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND6 zinc finger, AN1-type domain 6
ZNF335 zinc finger protein 335

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ADM adrenomedullin
ASB13 ankyrin repeat and SOCS box containing 13
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BATF basic leucine zipper transcription factor, ATF-like
BBS10 Bardet-Biedl syndrome 10
C17ORF70 chromosome 17 open reading frame 70
CALHM2 calcium homeostasis modulator 2
CBR1 carbonyl reductase 1
CBY1 chibby homolog 1 (Drosophila)
CCNE2 cyclin E2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DCLRE1A DNA cross-link repair 1A
DENND2D DENN/MADD domain containing 2D
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DUSP6 dual specificity phosphatase 6
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFTUD1 elongation factor Tu GTP binding domain containing 1
ETAA1 Ewing tumor-associated antigen 1
FADD Fas (TNFRSF6)-associated via death domain
FBXL15 F-box and leucine-rich repeat protein 15
FPGT fucose-1-phosphate guanylyltransferase
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GPR63 G protein-coupled receptor 63
ICT1 immature colon carcinoma transcript 1
IFT81 intraflagellar transport 81
JRKL JRK-like
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLF11 Kruppel-like factor 11
LINC00339 long intergenic non-protein coding RNA 339
LRRC8D leucine rich repeat containing 8 family, member D
MAT2A methionine adenosyltransferase II, alpha
MCRS1 microspherule protein 1
METTL8 methyltransferase like 8
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MINPP1 multiple inositol-polyphosphate phosphatase 1
MKKS McKusick-Kaufman syndrome
MOCS2 molybdenum cofactor synthesis 2
MRPL17 mitochondrial ribosomal protein L17
MSRB1 methionine sulfoxide reductase B1
MXD3 MAX dimerization protein 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAGK N-acetylglucosamine kinase
NAT6 N-acetyltransferase 6 (GCN5-related)
NFE2 nuclear factor, erythroid 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NTSR1 neurotensin receptor 1 (high affinity)
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ORAI3 ORAI calcium release-activated calcium modulator 3
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PEX12 peroxisomal biogenesis factor 12
PIAS3 protein inhibitor of activated STAT, 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNMA1 paraneoplastic Ma antigen 1
POGK pogo transposable element with KRAB domain
PRDM13 PR domain containing 13
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRR3 proline rich 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOBTB1 Rho-related BTB domain containing 1
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RPP40 ribonuclease P/MRP 40kDa subunit
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMD9 sterile alpha motif domain containing 9
SETD8 SET domain containing (lysine methyltransferase) 8
SLC35A5 solute carrier family 35, member A5
SLITRK5 SLIT and NTRK-like family, member 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK16 serine/threonine kinase 16
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TM2D3 TM2 domain containing 3
TMEM177 transmembrane protein 177
TMEM243 transmembrane protein 243, mitochondrial
TNNT1 troponin T type 1 (skeletal, slow)
UBL4A ubiquitin-like 4A
WDR3 WD repeat domain 3
WDR5B WD repeat domain 5B
XPA xeroderma pigmentosum, complementation group A
ZNF23 zinc finger protein 23
ZNF250 zinc finger protein 250
ZNF302 zinc finger protein 302
ZNF32 zinc finger protein 32
ZNF33B zinc finger protein 33B
ZNF354A zinc finger protein 354A
ZNF536 zinc finger protein 536
ZNF623 zinc finger protein 623
ZNF7 zinc finger protein 7
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZW10 zw10 kinetochore protein