difenidol-7447 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the difenidol-7447 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
AFAP1 actin filament associated protein 1
ARHGAP33 Rho GTPase activating protein 33
ARHGAP44 Rho GTPase activating protein 44
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BTG2 BTG family, member 2
C1ORF61 chromosome 1 open reading frame 61
CCDC93 coiled-coil domain containing 93
CD44 CD44 molecule (Indian blood group)
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK20 cyclin-dependent kinase 20
CEP104 centrosomal protein 104kDa
CHM choroideremia (Rab escort protein 1)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CTAGE5 CTAGE family, member 5
CTSZ cathepsin Z
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK4 docking protein 4
DVL1 dishevelled segment polarity protein 1
ECE1 endothelin converting enzyme 1
ELOVL4 ELOVL fatty acid elongase 4
ELP6 elongator acetyltransferase complex subunit 6
EPS8L3 EPS8-like 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM65A family with sequence similarity 65, member A
FBXO2 F-box protein 2
FGFR4 fibroblast growth factor receptor 4
FLOT1 flotillin 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GRPR gastrin-releasing peptide receptor
GSPT1 G1 to S phase transition 1
GSTM4 glutathione S-transferase mu 4
HABP4 hyaluronan binding protein 4
HBEGF heparin-binding EGF-like growth factor
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HDLBP high density lipoprotein binding protein
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL22 interleukin 22
ING4 inhibitor of growth family, member 4
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KCTD17 potassium channel tetramerization domain containing 17
KDM6A lysine (K)-specific demethylase 6A
KLHL24 kelch-like family member 24
LIG3 ligase III, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
MAP4 microtubule-associated protein 4
MOCS1 molybdenum cofactor synthesis 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDRG2 NDRG family member 2
NF2 neurofibromin 2 (merlin)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NOX1 NADPH oxidase 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLAC1 placenta-specific 1
PLXNB1 plexin B1
PODNL1 podocan-like 1
POM121 POM121 transmembrane nucleoporin
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PSAT1 phosphoserine aminotransferase 1
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP3 RAN binding protein 3
RBM19 RNA binding motif protein 19
RECQL5 RecQ protein-like 5
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN3 Ras and Rab interactor 3
RPL10 ribosomal protein L10
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RTN2 reticulon 2
RUNX1 runt-related transcription factor 1
SH3BP2 SH3-domain binding protein 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPTAN1 spectrin, alpha, non-erythrocytic 1
STIM1 stromal interaction molecule 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TMC7 transmembrane channel-like 7
TREX1 three prime repair exonuclease 1
TTLL3 tubulin tyrosine ligase-like family member 3
TXNL4A thioredoxin-like 4A
ULK2 unc-51 like autophagy activating kinase 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR55 WD repeat domain 55
WDTC1 WD and tetratricopeptide repeats 1
YY2 YY2 transcription factor
ZC3H7B zinc finger CCCH-type containing 7B
ZFP36L2 ZFP36 ring finger protein-like 2
ZFX zinc finger protein, X-linked
ZNF442 zinc finger protein 442
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRD36 ankyrin repeat domain 36
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATRN attractin
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF30 chromosome 11 open reading frame 30
C12ORF4 chromosome 12 open reading frame 4
C16ORF45 chromosome 16 open reading frame 45
C19ORF40 chromosome 19 open reading frame 40
C21ORF91 chromosome 21 open reading frame 91
C2ORF44 chromosome 2 open reading frame 44
C7ORF43 chromosome 7 open reading frame 43
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC186 coiled-coil domain containing 186
CENPQ centromere protein Q
CHIC2 cysteine-rich hydrophobic domain 2
CIC capicua transcriptional repressor
CPTP ceramide-1-phosphate transfer protein
CTAGE9 CTAGE family, member 9
CTC1 CTS telomere maintenance complex component 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DEAF1 DEAF1 transcription factor
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EIF5A2 eukaryotic translation initiation factor 5A2
FBXO46 F-box protein 46
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GPATCH3 G patch domain containing 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPX2 glutathione peroxidase 2
H2AFY2 H2A histone family, member Y2
HIST1H2BI histone cluster 1, H2bi
IL15RA interleukin 15 receptor, alpha
IP6K1 inositol hexakisphosphate kinase 1
IRF9 interferon regulatory factor 9
LHFPL2 lipoma HMGIC fusion partner-like 2
LINS lines homolog (Drosophila)
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
METTL2B methyltransferase like 2B
MFSD12 major facilitator superfamily domain containing 12
MITF microphthalmia-associated transcription factor
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MNX1 motor neuron and pancreas homeobox 1
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTMR11 myotubularin related protein 11
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NMU neuromedin U
PC pyruvate carboxylase
PCDHGB5 protocadherin gamma subfamily B, 5
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX26 peroxisomal biogenesis factor 26
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPCDC phosphopantothenoylcysteine decarboxylase
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPT2 palmitoyl-protein thioesterase 2
PRR3 proline rich 3
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTCD2 pentatricopeptide repeat domain 2
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP5 RAB11 family interacting protein 5 (class I)
REPS2 RALBP1 associated Eps domain containing 2
RIPK4 receptor-interacting serine-threonine kinase 4
RPUSD2 RNA pseudouridylate synthase domain containing 2
SHARPIN SHANK-associated RH domain interactor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SP1 Sp1 transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
TCTN1 tectonic family member 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM104 transmembrane protein 104
TMEM180 transmembrane protein 180
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TROAP trophinin associated protein
UFSP2 UFM1-specific peptidase 2
ULBP2 UL16 binding protein 2
VASP vasodilator-stimulated phosphoprotein
ZBED8 zinc finger, BED-type containing 8
ZMAT5 zinc finger, matrin-type 5
ZNF219 zinc finger protein 219
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF408 zinc finger protein 408
ZNF552 zinc finger protein 552
ZNF669 zinc finger protein 669
ZXDC ZXD family zinc finger C