diethylcarbamazine-7425 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the diethylcarbamazine-7425 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADRBK1 adrenergic, beta, receptor kinase 1
AGGF1 angiogenic factor with G patch and FHA domains 1
AKR1C2 aldo-keto reductase family 1, member C2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
AZI2 5-azacytidine induced 2
BBS10 Bardet-Biedl syndrome 10
BBS9 Bardet-Biedl syndrome 9
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL9 B-cell CLL/lymphoma 9
BLZF1 basic leucine zipper nuclear factor 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CEP170 centrosomal protein 170kDa
CEP72 centrosomal protein 72kDa
CLCN7 chloride channel, voltage-sensitive 7
CLN5 ceroid-lipofuscinosis, neuronal 5
CUL2 cullin 2
CUL4B cullin 4B
DCAF17 DDB1 and CUL4 associated factor 17
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EED embryonic ectoderm development
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EIF5B eukaryotic translation initiation factor 5B
FAM65A family with sequence similarity 65, member A
FECH ferrochelatase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGD1 FYVE, RhoGEF and PH domain containing 1
FLOT1 flotillin 1
FSCN1 fascin actin-bundling protein 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GOSR2 golgi SNAP receptor complex member 2
GSTCD glutathione S-transferase, C-terminal domain containing
HIPK3 homeodomain interacting protein kinase 3
IFT22 intraflagellar transport 22
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KDM5A lysine (K)-specific demethylase 5A
KDM6A lysine (K)-specific demethylase 6A
LIN7A lin-7 homolog A (C. elegans)
LOC399491
LPCAT3 lysophosphatidylcholine acyltransferase 3
MBNL2 muscleblind-like splicing regulator 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MINPP1 multiple inositol-polyphosphate phosphatase 1
MORC3 MORC family CW-type zinc finger 3
MPDZ multiple PDZ domain protein
MPPED2 metallophosphoesterase domain containing 2
MVB12B multivesicular body subunit 12B
N4BP3 NEDD4 binding protein 3
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PIAS4 protein inhibitor of activated STAT, 4
PICALM phosphatidylinositol binding clathrin assembly protein
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLK4 polo-like kinase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPAP2B phosphatidic acid phosphatase type 2B
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDX2 peroxiredoxin 2
PRKCI protein kinase C, iota
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RANBP2 RAN binding protein 2
RANBP3 RAN binding protein 3
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBL2 retinoblastoma-like 2
RBM48 RNA binding motif protein 48
RNF6 ring finger protein (C3H2C3 type) 6
RPS2 ribosomal protein S2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC63 SEC63 homolog (S. cerevisiae)
SETD4 SET domain containing 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOX4 SRY (sex determining region Y)-box 4
SRSF5 serine/arginine-rich splicing factor 5
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAG3 stromal antigen 3
STK17B serine/threonine kinase 17b
TANK TRAF family member-associated NFKB activator
TCP11L1 t-complex 11, testis-specific-like 1
TESK1 testis-specific kinase 1
TGFB3 transforming growth factor, beta 3
THBD thrombomodulin
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMCO3 transmembrane and coiled-coil domains 3
TMEM180 transmembrane protein 180
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRAIP TRAF interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR55 WD repeat domain 55
WWTR1 WW domain containing transcription regulator 1
ZNF141 zinc finger protein 141

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALPK1 alpha-kinase 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARL15 ADP-ribosylation factor-like 15
ARMC6 armadillo repeat containing 6
ASCC2 activating signal cointegrator 1 complex subunit 2
ATAD3A ATPase family, AAA domain containing 3A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BACE1 beta-site APP-cleaving enzyme 1
BTBD2 BTB (POZ) domain containing 2
C17ORF70 chromosome 17 open reading frame 70
CAPN5 calpain 5
CARD8 caspase recruitment domain family, member 8
CCDC64 coiled-coil domain containing 64
CCDC85C coiled-coil domain containing 85C
CENPO centromere protein O
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CSTA cystatin A (stefin A)
DALRD3 DALR anticodon binding domain containing 3
DDIT3 DNA-damage-inducible transcript 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DMTN dematin actin binding protein
DYSF dysferlin
EDAR ectodysplasin A receptor
FAM131A family with sequence similarity 131, member A
FBXL6 F-box and leucine-rich repeat protein 6
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FURIN furin (paired basic amino acid cleaving enzyme)
FUZ fuzzy planar cell polarity protein
FZD4 frizzled class receptor 4
GATA4 GATA binding protein 4
GNL1 guanine nucleotide binding protein-like 1
GPR27 G protein-coupled receptor 27
HIST1H2AE histone cluster 1, H2ae
HIST1H2BO histone cluster 1, H2bo
HIST1H4J histone cluster 1, H4j
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KRT13 keratin 13, type I
LOC100287590 uncharacterized LOC100287590
LOC390998 ribosomal protein L10 pseudogene
LRRC20 leucine rich repeat containing 20
LZTS3 leucine zipper, putative tumor suppressor family member 3
MANBA mannosidase, beta A, lysosomal
MAP1S microtubule-associated protein 1S
MCC mutated in colorectal cancers
MCOLN1 mucolipin 1
MFSD11 major facilitator superfamily domain containing 11
NDRG4 NDRG family member 4
NINL ninein-like
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
PCBP4 poly(rC) binding protein 4
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRODH proline dehydrogenase (oxidase) 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRSS16 protease, serine, 16 (thymus)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB30 RAB30, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RECQL4 RecQ protein-like 4
REPS2 RALBP1 associated Eps domain containing 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF123 ring finger protein 123
RNF126P1 ring finger protein 126 pseudogene 1
RPS15A ribosomal protein S15a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
S100A9 S100 calcium binding protein A9
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SNAI2 snail family zinc finger 2
SPATA2L spermatogenesis associated 2-like
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNK1 tyrosine kinase, non-receptor, 1
TPCN1 two pore segment channel 1
TTLL1 tubulin tyrosine ligase-like family member 1
USP20 ubiquitin specific peptidase 20
VEGFB vascular endothelial growth factor B
VPS9D1 VPS9 domain containing 1
WDR25 WD repeat domain 25
WDR60 WD repeat domain 60
ZNF219 zinc finger protein 219
ZNF324 zinc finger protein 324
ZNF329 zinc finger protein 329
ZNF767P zinc finger family member 767, pseudogene
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZSCAN26 zinc finger and SCAN domain containing 26