dienestrol-6208 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the dienestrol-6208 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM17 ADAM metallopeptidase domain 17
ADGRG1 adhesion G protein-coupled receptor G1
AEN apoptosis enhancing nuclease
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APOL6 apolipoprotein L, 6
ARHGAP35 Rho GTPase activating protein 35
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATF3 activating transcription factor 3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
C1ORF105 chromosome 1 open reading frame 105
CA12 carbonic anhydrase XII
CD4 CD4 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CRISP2 cysteine-rich secretory protein 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYBG3 beta-gamma crystallin domain containing 3
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DZIP3 DAZ interacting zinc finger protein 3
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL2 ELOVL fatty acid elongase 2
FKBP8 FK506 binding protein 8, 38kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GLG1 golgi glycoprotein 1
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HEG1 heart development protein with EGF-like domains 1
HIST1H2AJ histone cluster 1, H2aj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ING1 inhibitor of growth family, member 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITSN1 intersectin 1 (SH3 domain protein)
JRK Jrk homolog (mouse)
JUN jun proto-oncogene
KDM8 lysine (K)-specific demethylase 8
KLF10 Kruppel-like factor 10
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LOC390998 ribosomal protein L10 pseudogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MPPE1 metallophosphoesterase 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
NGLY1 N-glycanase 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PYGB phosphorylase, glycogen; brain
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF24 ring finger protein 24
RPL10 ribosomal protein L10
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SIK2 salt-inducible kinase 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMOX spermine oxidase
SMTN smoothelin
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SUGP1 SURP and G patch domain containing 1
TBC1D17 TBC1 domain family, member 17
TJAP1 tight junction associated protein 1 (peripheral)
TMEM259 transmembrane protein 259
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
VARS valyl-tRNA synthetase
VASH2 vasohibin 2
VEGFA vascular endothelial growth factor A
VIPR2 vasoactive intestinal peptide receptor 2
WDR62 WD repeat domain 62
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF34 zinc finger protein 34
ZNF589 zinc finger protein 589
ZNF747 zinc finger protein 747
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ANKRD36 ankyrin repeat domain 36
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID4A AT rich interactive domain 4A (RBP1-like)
ASB9 ankyrin repeat and SOCS box containing 9
BACE1 beta-site APP-cleaving enzyme 1
BAK1 BCL2-antagonist/killer 1
BBC3 BCL2 binding component 3
C4ORF29 chromosome 4 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
CAPG capping protein (actin filament), gelsolin-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNL2 cyclin L2
CDK3 cyclin-dependent kinase 3
CERK ceramide kinase
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL4A5 collagen, type IV, alpha 5
CORT cortistatin
CPPED1 calcineurin-like phosphoesterase domain containing 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DTWD1 DTW domain containing 1
DUS2 dihydrouridine synthase 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM192A family with sequence similarity 192, member A
FCHO1 FCH domain only 1
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GPALPP1 GPALPP motifs containing 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INCENP inner centromere protein antigens 135/155kDa
INSIG2 insulin induced gene 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT8P12 keratin 8 pseudogene 12
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC730101 uncharacterized LOC730101
LRP5 low density lipoprotein receptor-related protein 5
LRRC8E leucine rich repeat containing 8 family, member E
LY6D lymphocyte antigen 6 complex, locus D
LZTR1 leucine-zipper-like transcription regulator 1
MANBA mannosidase, beta A, lysosomal
MRPL2 mitochondrial ribosomal protein L2
MYO1E myosin IE
NACA2 nascent polypeptide-associated complex alpha subunit 2
NLK nemo-like kinase
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP16 poly (ADP-ribose) polymerase family, member 16
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDZRN3 PDZ domain containing ring finger 3
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLD3 phospholipase D family, member 3
PP14571 uncharacterized LOC100130449
PRSS22 protease, serine, 22
RAB27B RAB27B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFX7 regulatory factor X, 7
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL23AP7 ribosomal protein L23a pseudogene 7
RWDD3 RWD domain containing 3
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SOX12 SRY (sex determining region Y)-box 12
SPATA7 spermatogenesis associated 7
TDRD1 tudor domain containing 1
TMC7 transmembrane channel-like 7
TMEM132A transmembrane protein 132A
TMEM62 transmembrane protein 62
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF2 TNF receptor-associated factor 2
TRAPPC2 trafficking protein particle complex 2
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
WDR4 WD repeat domain 4
ZFHX3 zinc finger homeobox 3
ZNF254 zinc finger protein 254
ZNF276 zinc finger protein 276
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene