diclofenamide-6686 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the diclofenamide-6686 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADGRE2 adhesion G protein-coupled receptor E2
ADPRH ADP-ribosylarginine hydrolase
ALDOB aldolase B, fructose-bisphosphate
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASCL1 achaete-scute family bHLH transcription factor 1
ATXN2L ataxin 2-like
BCR breakpoint cluster region
BICC1 BicC family RNA binding protein 1
BMPR1B bone morphogenetic protein receptor, type IB
C8ORF4 chromosome 8 open reading frame 4
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC170 coiled-coil domain containing 170
CCDC64 coiled-coil domain containing 64
CCL8 chemokine (C-C motif) ligand 8
CD7 CD7 molecule
CDHR5 cadherin-related family member 5
CISH cytokine inducible SH2-containing protein
CIZ1 CDKN1A interacting zinc finger protein 1
CLCN4 chloride channel, voltage-sensitive 4
CPNE7 copine VII
CREBZF CREB/ATF bZIP transcription factor
DOC2A double C2-like domains, alpha
DSC1 desmocollin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EHD2 EH-domain containing 2
EMID1 EMI domain containing 1
FES FES proto-oncogene, tyrosine kinase
FGF4 fibroblast growth factor 4
GLP1R glucagon-like peptide 1 receptor
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
GRM1 glutamate receptor, metabotropic 1
GRM4 glutamate receptor, metabotropic 4
HABP4 hyaluronan binding protein 4
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HOXD13 homeobox D13
HSF1 heat shock transcription factor 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITPKA inositol-trisphosphate 3-kinase A
KALRN kalirin, RhoGEF kinase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLHL22 kelch-like family member 22
LDLRAD4 low density lipoprotein receptor class A domain containing 4
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MRC2 mannose receptor, C type 2
MTCP1 mature T-cell proliferation 1
MYEF2 myelin expression factor 2
NCAM1 neural cell adhesion molecule 1
NCOR2 nuclear receptor corepressor 2
NME8 NME/NM23 family member 8
NNAT neuronatin
NOX1 NADPH oxidase 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRG1 neuregulin 1
NRXN3 neurexin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OMD osteomodulin
PAX3 paired box 3
PDCD2 programmed cell death 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNB3 plexin B3
PRKCA protein kinase C, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RAB6A RAB6A, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS3 RNA binding motif, single stranded interacting protein 3
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RET ret proto-oncogene
RGS12 regulator of G-protein signaling 12
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SOCS3 suppressor of cytokine signaling 3
SORBS2 sorbin and SH3 domain containing 2
SOS2 son of sevenless homolog 2 (Drosophila)
SOX10 SRY (sex determining region Y)-box 10
SOX21 SRY (sex determining region Y)-box 21
SPAG8 sperm associated antigen 8
TAOK2 TAO kinase 2
TBC1D30 TBC1 domain family, member 30
TBKBP1 TBK1 binding protein 1
TLX2 T-cell leukemia homeobox 2
TMPRSS4 transmembrane protease, serine 4
TRIM3 tripartite motif containing 3
TSKS testis-specific serine kinase substrate
TUBA3C tubulin, alpha 3c
WWOX WW domain containing oxidoreductase

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AEN apoptosis enhancing nuclease
AGMAT agmatine ureohydrolase (agmatinase)
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATAT1 alpha tubulin acetyltransferase 1
BBS7 Bardet-Biedl syndrome 7
C14ORF93 chromosome 14 open reading frame 93
C1ORF56 chromosome 1 open reading frame 56
C4ORF29 chromosome 4 open reading frame 29
CASZ1 castor zinc finger 1
CDH7 cadherin 7, type 2
CEP131 centrosomal protein 131kDa
CHRDL1 chordin-like 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DDN dendrin
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND4A DENN/MADD domain containing 4A
F8 coagulation factor VIII, procoagulant component
FBXL7 F-box and leucine-rich repeat protein 7
FBXW12 F-box and WD repeat domain containing 12
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP10 FK506 binding protein 10, 65 kDa
FRS3 fibroblast growth factor receptor substrate 3
FYCO1 FYVE and coiled-coil domain containing 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GID4 GID complex subunit 4
GMPR guanosine monophosphate reductase
GRAMD1C GRAM domain containing 1C
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2AM histone cluster 1, H2am
HIST1H2BN histone cluster 1, H2bn
HIST2H2AA3 histone cluster 2, H2aa3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA7 homeobox A7
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA1L heat shock 70kDa protein 1-like
IER3IP1 immediate early response 3 interacting protein 1
ISYNA1 inositol-3-phosphate synthase 1
KDM8 lysine (K)-specific demethylase 8
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KPTN kaptin (actin binding protein)
LOC257152 uncharacterized LOC257152
LRRC6 leucine rich repeat containing 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD3 LY6/PLAUR domain containing 3
MMRN2 multimerin 2
MRPL41 mitochondrial ribosomal protein L41
MSX1 msh homeobox 1
MUC3B mucin 3B, cell surface associated
MYL9 myosin, light chain 9, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NPM3 nucleophosmin/nucleoplasmin 3
NRTN neurturin
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAIP2B poly(A) binding protein interacting protein 2B
PARD6A par-6 family cell polarity regulator alpha
PCBP4 poly(rC) binding protein 4
PER3 period circadian clock 3
PICK1 protein interacting with PRKCA 1
PMCH pro-melanin-concentrating hormone
PRPH peripherin
PRR14L proline rich 14-like
PRR15L proline rich 15-like
RAB3A RAB3A, member RAS oncogene family
RAI2 retinoic acid induced 2
RNF2 ring finger protein 2
RPGR retinitis pigmentosa GTPase regulator
RPL23AP32 ribosomal protein L23a pseudogene 32
SCIN scinderin
SERGEF secretion regulating guanine nucleotide exchange factor
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOBP sine oculis binding protein homolog (Drosophila)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK16 serine/threonine kinase 16
TESK1 testis-specific kinase 1
TESPA1 thymocyte expressed, positive selection associated 1
TM6SF1 transmembrane 6 superfamily member 1
TMC7 transmembrane channel-like 7
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TMSB15A thymosin beta 15a
ZC2HC1C zinc finger, C2HC-type containing 1C
ZC3H12A zinc finger CCCH-type containing 12A
ZNF165 zinc finger protein 165
ZNF230 zinc finger protein 230
ZNF442 zinc finger protein 442
ZNF480 zinc finger protein 480
ZNF671 zinc finger protein 671
ZNF770 zinc finger protein 770
ZSCAN2 zinc finger and SCAN domain containing 2
ZXDC ZXD family zinc finger C