diclofenac-7215 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the diclofenac-7215 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAM17 ADAM metallopeptidase domain 17
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C4 aldo-keto reductase family 1, member C4
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C15ORF39 chromosome 15 open reading frame 39
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CAPN5 calpain 5
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CES3 carboxylesterase 3
CHM choroideremia (Rab escort protein 1)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA1 chloride channel accessory 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSHL1 chorionic somatomammotropin hormone-like 1
DACH1 dachshund family transcription factor 1
DIO2 deiodinase, iodothyronine, type II
DPF1 D4, zinc and double PHD fingers family 1
DPYS dihydropyrimidinase
ELP6 elongator acetyltransferase complex subunit 6
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM189A2 family with sequence similarity 189, member A2
FLJ11292
FRS3 fibroblast growth factor receptor substrate 3
FUT2 fucosyltransferase 2 (secretor status included)
GJA8 gap junction protein, alpha 8, 50kDa
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GMPR guanosine monophosphate reductase
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNL1 guanine nucleotide binding protein-like 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR176 G protein-coupled receptor 176
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H2BN histone cluster 1, H2bn
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFT122 intraflagellar transport 122
ING2 inhibitor of growth family, member 2
IPCEF1 interaction protein for cytohesin exchange factors 1
IRAK3 interleukin-1 receptor-associated kinase 3
ITGA10 integrin, alpha 10
KCNK12 potassium channel, two pore domain subfamily K, member 12
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19P2 keratin 19 pseudogene 2
LIG4 ligase IV, DNA, ATP-dependent
LPXN leupaxin
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAOA monoamine oxidase A
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MEF2C myocyte enhancer factor 2C
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
NAAA N-acylethanolamine acid amidase
NCOA2 nuclear receptor coactivator 2
NEB nebulin
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NUMA1 nuclear mitotic apparatus protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OCA2 oculocutaneous albinism II
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OTUD4 OTU deubiquitinase 4
PAPOLA poly(A) polymerase alpha
PDGFA platelet-derived growth factor alpha polypeptide
PIP prolactin-induced protein
PRSS16 protease, serine, 16 (thymus)
PSG4 pregnancy specific beta-1-glycoprotein 4
RAD51 RAD51 recombinase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS12 regulator of G-protein signaling 12
RNF170 ring finger protein 170
RUNX1 runt-related transcription factor 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SGSM3 small G protein signaling modulator 3
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYBU syntabulin (syntaxin-interacting)
SYNPO synaptopodin
TAOK2 TAO kinase 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TUBA3C tubulin, alpha 3c
USP34 ubiquitin specific peptidase 34
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF358 zinc finger protein 358
ZNF770 zinc finger protein 770
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACYP1 acylphosphatase 1, erythrocyte (common) type
ALPK1 alpha-kinase 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
C14ORF132 chromosome 14 open reading frame 132
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
CAPN1 calpain 1, (mu/I) large subunit
CBX4 chromobox homolog 4
CCNO cyclin O
CD302 CD302 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPQ centromere protein Q
CEP85 centrosomal protein 85kDa
CLDN15 claudin 15
CNGB3 cyclic nucleotide gated channel beta 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DUSP8 dual specificity phosphatase 8
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHA2 EPH receptor A2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRAMD4 GRAM domain containing 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTPBP6 GTP binding protein 6 (putative)
H2AFJ H2A histone family, member J
KLHL26 kelch-like family member 26
KREMEN2 kringle containing transmembrane protein 2
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINS lines homolog (Drosophila)
LMNB1 lamin B1
LZTFL1 leucine zipper transcription factor-like 1
MANBA mannosidase, beta A, lysosomal
MED15 mediator complex subunit 15
MMP9 matrix metallopeptidase 9
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MUM1 melanoma associated antigen (mutated) 1
NAV2 neuron navigator 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NKAIN1 Na+/K+ transporting ATPase interacting 1
NRSN2 neurensin 2
PDZD8 PDZ domain containing 8
PGP phosphoglycolate phosphatase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLD3 phospholipase D family, member 3
POLH polymerase (DNA directed), eta
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRU protein tyrosine phosphatase, receptor type, U
RBL1 retinoblastoma-like 1
REST RE1-silencing transcription factor
RNF2 ring finger protein 2
RNF25 ring finger protein 25
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETD8 SET domain containing (lysine methyltransferase) 8
SIK1 salt-inducible kinase 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX12 SRY (sex determining region Y)-box 12
SPATA2L spermatogenesis associated 2-like
SPIDR scaffolding protein involved in DNA repair
TBL3 transducin (beta)-like 3
TESK1 testis-specific kinase 1
TFB1M transcription factor B1, mitochondrial
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLN1 talin 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC5 transmembrane channel-like 5
TMEM104 transmembrane protein 104
TPST1 tyrosylprotein sulfotransferase 1
TRAPPC2 trafficking protein particle complex 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASH1 vasohibin 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
YBX2 Y box binding protein 2
ZNF219 zinc finger protein 219
ZNF468 zinc finger protein 468
ZNF552 zinc finger protein 552
ZNF573 zinc finger protein 573
ZNF668 zinc finger protein 668
ZNF7 zinc finger protein 7
ZNF767P zinc finger family member 767, pseudogene
ZNF778 zinc finger protein 778