diclofenac-445 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the diclofenac-445 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANGPTL2 angiopoietin-like 2
ANK1 ankyrin 1, erythrocytic
AQP6 aquaporin 6, kidney specific
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BTN2A1 butyrophilin, subfamily 2, member A1
C7ORF43 chromosome 7 open reading frame 43
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV3 caveolin 3
CEP162 centrosomal protein 162kDa
CTSE cathepsin E
DLK2 delta-like 2 homolog (Drosophila)
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DRG2 developmentally regulated GTP binding protein 2
DXO decapping exoribonuclease
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F6 E2F transcription factor 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ELMO2 engulfment and cell motility 2
ESR2 estrogen receptor 2 (ER beta)
EVPL envoplakin
EYA1 EYA transcriptional coactivator and phosphatase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGR FGR proto-oncogene, Src family tyrosine kinase
FOSL2 FOS-like antigen 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALR3 galanin receptor 3
GSK3A glycogen synthase kinase 3 alpha
H2AFY2 H2A histone family, member Y2
HABP2 hyaluronan binding protein 2
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INO80B INO80 complex subunit B
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL25 kelch-like family member 25
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LINC01558 long intergenic non-protein coding RNA 1558
LOC100286895 cell division cycle 27 homolog pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene)
MIP major intrinsic protein of lens fiber
MOGAT2 monoacylglycerol O-acyltransferase 2
MRPS12 mitochondrial ribosomal protein S12
MST1 macrophage stimulating 1
MX1 MX dynamin-like GTPase 1
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCS1 neuronal calcium sensor 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NIPAL3 NIPA-like domain containing 3
NOTCH2 notch 2
NRXN1 neurexin 1
NXPH4 neurexophilin 4
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PCDH11Y protocadherin 11 Y-linked
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G5 phospholipase A2, group V
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODNL1 podocan-like 1
PRB1 proline-rich protein BstNI subfamily 1
PRSS8 protease, serine, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40AL RAB40A, member RAS oncogene family-like
RAB5C RAB5C, member RAS oncogene family
RARG retinoic acid receptor, gamma
RC3H2 ring finger and CCCH-type domains 2
RIMS2 regulating synaptic membrane exocytosis 2
RRH retinal pigment epithelium-derived rhodopsin homolog
SDPR serum deprivation response
SH2D3A SH2 domain containing 3A
SLA Src-like-adaptor
SLC19A1 solute carrier family 19 (folate transporter), member 1
SNPH syntaphilin
SP1 Sp1 transcription factor
SPN sialophorin
TGM3 transglutaminase 3
THBS3 thrombospondin 3
TLN2 talin 2
TMEM53 transmembrane protein 53
TRIO trio Rho guanine nucleotide exchange factor
UBE3A ubiquitin protein ligase E3A
UTRN utrophin
VWA5A von Willebrand factor A domain containing 5A
WDR1 WD repeat domain 1
WDR48 WD repeat domain 48
WNT10B wingless-type MMTV integration site family, member 10B
ZC3H13 zinc finger CCCH-type containing 13
ZNF460 zinc finger protein 460
ZNF507 zinc finger protein 507
ZNF771 zinc finger protein 771
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACBD4 acyl-CoA binding domain containing 4
ATAD2B ATPase family, AAA domain containing 2B
ATF7 activating transcription factor 7
ATF7IP2 activating transcription factor 7 interacting protein 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL9 B-cell CLL/lymphoma 9
BEST2 bestrophin 2
BTBD2 BTB (POZ) domain containing 2
C19ORF57 chromosome 19 open reading frame 57
C2ORF44 chromosome 2 open reading frame 44
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC91 coiled-coil domain containing 91
CCP110 centriolar coiled coil protein 110kDa
CD70 CD70 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDT1 chromatin licensing and DNA replication factor 1
CEP170B centrosomal protein 170B
CEPT1 choline/ethanolamine phosphotransferase 1
CETN1 centrin, EF-hand protein, 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLTCL1 clathrin, heavy chain-like 1
CRYAB crystallin, alpha B
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYB5R3 cytochrome b5 reductase 3
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCAF16 DDB1 and CUL4 associated factor 16
DENND4C DENN/MADD domain containing 4C
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM222B family with sequence similarity 222, member B
FOXC1 forkhead box C1
GBAP1 glucosidase, beta, acid pseudogene 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLMN glomulin, FKBP associated protein
GPR3 G protein-coupled receptor 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC5 histone deacetylase 5
HP1BP3 heterochromatin protein 1, binding protein 3
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLHL28 kelch-like family member 28
KRI1 KRI1 homolog (S. cerevisiae)
LDHC lactate dehydrogenase C
LGALS13 lectin, galactoside-binding, soluble, 13
LSR lipolysis stimulated lipoprotein receptor
MELK maternal embryonic leucine zipper kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP8 matrix metallopeptidase 8
MRPL35 mitochondrial ribosomal protein L35
MT1M metallothionein 1M
MYL1 myosin, light chain 1, alkali; skeletal, fast
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI1 peptidyl arginine deiminase, type I
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PFAS phosphoribosylformylglycinamidine synthase
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLM polymerase (DNA directed), mu
POU5F1B POU class 5 homeobox 1B
PRICKLE3 prickle homolog 3 (Drosophila)
PTX3 pentraxin 3, long
RAP1GAP2 RAP1 GTPase activating protein 2
RASL10A RAS-like, family 10, member A
RNF208 ring finger protein 208
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSF1 remodeling and spacing factor 1
SH2D4A SH2 domain containing 4A
SLC17A4 solute carrier family 17, member 4
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SPAG16 sperm associated antigen 16
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SYT17 synaptotagmin XVII
SYT2 synaptotagmin II
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TOE1 target of EGR1, member 1 (nuclear)
TRIM5 tripartite motif containing 5
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TYR tyrosinase
UBIAD1 UbiA prenyltransferase domain containing 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USB1 U6 snRNA biogenesis 1
VIPR1 vasoactive intestinal peptide receptor 1
ZMAT5 zinc finger, matrin-type 5
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF408 zinc finger protein 408
ZNF432 zinc finger protein 432
ZNF696 zinc finger protein 696