diazoxide-7168 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the diazoxide-7168 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AKR1C2 aldo-keto reductase family 1, member C2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ATM ATM serine/threonine kinase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BMP1 bone morphogenetic protein 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C10ORF95 chromosome 10 open reading frame 95
CD302 CD302 molecule
CD58 CD58 molecule
CDH8 cadherin 8, type 2
CFLAR CASP8 and FADD-like apoptosis regulator
CLASP2 cytoplasmic linker associated protein 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSTA cystatin A (stefin A)
CTAGE5 CTAGE family, member 5
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNS cystinosin, lysosomal cystine transporter
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EGFL7 EGF-like-domain, multiple 7
EMC1 ER membrane protein complex subunit 1
EPHB6 EPH receptor B6
GAS7 growth arrest-specific 7
GON4L gon-4-like (C. elegans)
GPR137 G protein-coupled receptor 137
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HDAC11 histone deacetylase 11
HFE hemochromatosis
HIST1H2BC histone cluster 1, H2bc
HRK harakiri, BCL2 interacting protein
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFT22 intraflagellar transport 22
IPP intracisternal A particle-promoted polypeptide
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2B integral membrane protein 2B
KDM8 lysine (K)-specific demethylase 8
KLHL22 kelch-like family member 22
LYPD1 LY6/PLAUR domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK11 mitogen-activated protein kinase 11
MBD3 methyl-CpG binding domain protein 3
MBNL2 muscleblind-like splicing regulator 2
MCC mutated in colorectal cancers
MYO1B myosin IB
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK11 NIMA-related kinase 11
NKTR natural killer cell triggering receptor
NOL12 nucleolar protein 12
OTUD3 OTU deubiquitinase 3
PACS1 phosphofurin acidic cluster sorting protein 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POLL polymerase (DNA directed), lambda
PRKCE protein kinase C, epsilon
PTBP3 polypyrimidine tract binding protein 3
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RER1 retention in endoplasmic reticulum sorting receptor 1
RIMS2 regulating synaptic membrane exocytosis 2
RPLP2 ribosomal protein, large, P2
RTEL1 regulator of telomere elongation helicase 1
RXRA retinoid X receptor, alpha
SAMD9 sterile alpha motif domain containing 9
SCAI suppressor of cancer cell invasion
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGSH N-sulfoglucosamine sulfohydrolase
SIK2 salt-inducible kinase 2
SKIL SKI-like proto-oncogene
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SOX4 SRY (sex determining region Y)-box 4
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRSF5 serine/arginine-rich splicing factor 5
SSX3 synovial sarcoma, X breakpoint 3
SUGP1 SURP and G patch domain containing 1
SYBU syntabulin (syntaxin-interacting)
TAPBP TAP binding protein (tapasin)
TBC1D17 TBC1 domain family, member 17
TEP1 telomerase-associated protein 1
TMEM120B transmembrane protein 120B
TMPO thymopoietin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TTC9 tetratricopeptide repeat domain 9
VIPR2 vasoactive intestinal peptide receptor 2
VPRBP Vpr (HIV-1) binding protein
ZNF440 zinc finger protein 440
ZNF451 zinc finger protein 451
ZNF573 zinc finger protein 573
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
AXIN1 axin 1
BACE1 beta-site APP-cleaving enzyme 1
BAHD1 bromo adjacent homology domain containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCAS1 breast carcinoma amplified sequence 1
BEX4 brain expressed, X-linked 4
C1ORF56 chromosome 1 open reading frame 56
C2ORF44 chromosome 2 open reading frame 44
C6ORF47 chromosome 6 open reading frame 47
CALCOCO1 calcium binding and coiled-coil domain 1
CASD1 CAS1 domain containing 1
CBX4 chromobox homolog 4
CCDC9 coiled-coil domain containing 9
CDK9 cyclin-dependent kinase 9
CEP85 centrosomal protein 85kDa
CIC capicua transcriptional repressor
COCH cochlin
CPTP ceramide-1-phosphate transfer protein
CRYL1 crystallin, lambda 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DEAF1 DEAF1 transcription factor
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FKBP14 FK506 binding protein 14, 22 kDa
FLCN folliculin
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FPGS folylpolyglutamate synthase
GAN gigaxonin
GRWD1 glutamate-rich WD repeat containing 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIRIP3 HIRA interacting protein 3
HIST1H1D histone cluster 1, H1d
HIST1H2BO histone cluster 1, H2bo
HPS6 Hermansky-Pudlak syndrome 6
IGFBP6 insulin-like growth factor binding protein 6
IL4R interleukin 4 receptor
IPO8 importin 8
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5C lysine (K)-specific demethylase 5C
KIAA0513 KIAA0513
KREMEN2 kringle containing transmembrane protein 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK12 mitogen-activated protein kinase 12
MATK megakaryocyte-associated tyrosine kinase
METTL21B methyltransferase like 21B
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NPM3 nucleophosmin/nucleoplasmin 3
NUP62CL nucleoporin 62kDa C-terminal like
PADI2 peptidyl arginine deiminase, type II
PAQR4 progestin and adipoQ receptor family member IV
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX26 peroxisomal biogenesis factor 26
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLA2G10 phospholipase A2, group X
PLD2 phospholipase D2
POLH polymerase (DNA directed), eta
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REPS2 RALBP1 associated Eps domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPAP1 RNA polymerase II associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SHPK sedoheptulokinase
SLC12A8 solute carrier family 12, member 8
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOX12 SRY (sex determining region Y)-box 12
SPAG4 sperm associated antigen 4
SYT17 synaptotagmin XVII
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTN2 tectonic family member 2
TESK1 testis-specific kinase 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THBS3 thrombospondin 3
TLR5 toll-like receptor 5
TSPAN14 tetraspanin 14
TUBGCP5 tubulin, gamma complex associated protein 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UEVLD UEV and lactate/malate dehyrogenase domains
ULBP2 UL16 binding protein 2
USB1 U6 snRNA biogenesis 1
VASH1 vasohibin 1
VAV1 vav 1 guanine nucleotide exchange factor
ZFAND3 zinc finger, AN1-type domain 3
ZNF268 zinc finger protein 268
ZNF668 zinc finger protein 668