diabetes, type 2 Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Similar Terms
Downloads & Tools

Genes

375 genes associated with the disease diabetes, type 2 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACP1 acid phosphatase 1, soluble
ADA adenosine deaminase
ADAM30 ADAM metallopeptidase domain 30
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADM adrenomedullin
ADRA2B adrenoceptor alpha 2B
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
ALOX12 arachidonate 12-lipoxygenase
ALX4 ALX homeobox 4
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOD apolipoprotein D
APOE apolipoprotein E
AR androgen receptor
ARMS2 age-related maculopathy susceptibility 2
ARNT aryl hydrocarbon receptor nuclear translocator
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCO1 beta-carotene oxygenase 1
BTC betacellulin
C4ORF32 chromosome 4 open reading frame 32
C5 complement component 5
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPN10 calpain 10
CARTPT CART prepropeptide
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CAT catalase
CBS cystathionine-beta-synthase
CCK cholecystokinin
CCKBR cholecystokinin B receptor
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD38 CD38 molecule
CDC123 cell division cycle 123
CDH22 cadherin 22, type 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CETP cholesteryl ester transfer protein, plasma
CFB complement factor B
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLPS colipase, pancreatic
CMA1 chymase 1, mast cell
COMMD5 COMM domain containing 5
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST1 cystatin SN
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R4 cytochrome b5 reductase 4
CYBA cytochrome b-245, alpha polypeptide
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCD dermcidin
DDIT3 DNA-damage-inducible transcript 3
DIO2 deiodinase, iodothyronine, type II
DLC1 DLC1 Rho GTPase activating protein
DRD2 dopamine receptor D2
DUSP12 dual specificity phosphatase 12
EDN1 endothelin 1
ELMO2 engulfment and cell motility 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ESR1 estrogen receptor 1
EXOC4 exocyst complex component 4
EXT2 exostosin glycosyltransferase 2
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP2 fatty acid binding protein 2, intestinal
FABP3 fatty acid binding protein 3, muscle and heart
FABP6 fatty acid binding protein 6, ileal
FGB fibrinogen beta chain
FGF2 fibroblast growth factor 2 (basic)
FN3K fructosamine 3 kinase
FOXA2 forkhead box A2
FOXC2 forkhead box C2
FOXO1 forkhead box O1
FTO fat mass and obesity associated
FXN frataxin
G6PC2 glucose-6-phosphatase, catalytic, 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GC group-specific component (vitamin D binding protein)
GCG glucagon
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GLP1R glucagon-like peptide 1 receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GPBAR1 G protein-coupled bile acid receptor 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPX1 glutathione peroxidase 1
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYS1 glycogen synthase 1 (muscle)
HAS2 hyaluronan synthase 2
HAS3 hyaluronan synthase 3
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IDDM3 insulin-dependent diabetes mellitus 3
IDDM4 insulin-dependent diabetes mellitus 4
IDE insulin-degrading enzyme
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL13 interleukin 13
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
INSR insulin receptor
INSRR insulin receptor-related receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JAZF1 JAZF zinc finger 1
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD15 potassium channel tetramerization domain containing 15
KIF11 kinesin family member 11
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KLF1 Kruppel-like factor 1 (erythroid)
KLF11 Kruppel-like factor 11
KLF12 Kruppel-like factor 12
KLF13 Kruppel-like factor 13
KLF15 Kruppel-like factor 15
KLF16 Kruppel-like factor 16
KLF2 Kruppel-like factor 2
KLF3 Kruppel-like factor 3 (basic)
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF8 Kruppel-like factor 8
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LCAT lecithin-cholesterol acyltransferase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIPC lipase, hepatic
LMNA lamin A/C
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LRGUK leucine-rich repeats and guanylate kinase domain containing
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MC4R melanocortin 4 receptor
MCM10 minichromosome maintenance complex component 10
MET MET proto-oncogene, receptor tyrosine kinase
MGST3 microsomal glutathione S-transferase 3
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MT-ND2 MTND2
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-TL1 tRNA
MT1A metallothionein 1A
MT1E metallothionein 1E
MT2A metallothionein 2A
MTAP methylthioadenosine phosphorylase
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
MTTP microsomal triglyceride transfer protein
NAMPT nicotinamide phosphoribosyltransferase
ND1
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRF1 nuclear respiratory factor 1
OGG1 8-oxoguanine DNA glycosylase
ONECUT1 one cut homeobox 1
OPRM1 opioid receptor, mu 1
OR52I1 olfactory receptor, family 52, subfamily I, member 1
PANK4 pantothenate kinase 4
PARK2 parkin RBR E3 ubiquitin protein ligase
PARL presenilin associated, rhomboid-like
PARP1 poly (ADP-ribose) polymerase 1
PAX4 paired box 4
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDX1 pancreatic and duodenal homeobox 1
PEPD peptidase D
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKLR pyruvate kinase, liver and RBC
PKN2 protein kinase N2
PNPLA3 patatin-like phospholipase domain containing 3
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PREP prolyl endopeptidase
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRKCB protein kinase C, beta
PRKCZ protein kinase C, zeta
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PVT1 Pvt1 oncogene (non-protein coding)
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
RETN resistin
RRAD Ras-related associated with diabetes
RXRG retinoid X receptor, gamma
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SDF2 stromal cell-derived factor 2
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHBG sex hormone-binding globulin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD3 SMAD family member 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SOS1 son of sevenless homolog 1 (Drosophila)
SREBF1 sterol regulatory element binding transcription factor 1
STAT4 signal transducer and activator of transcription 4
STX1A syntaxin 1A (brain)
SUMO4 small ubiquitin-like modifier 4
SYN1 synapsin I
TCF20 transcription factor 20 (AR1)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRIB3 tribbles pseudokinase 3
TRIM68 tripartite motif containing 68
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSPAN8 tetraspanin 8
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USF1 upstream transcription factor 1
UTS2 urotensin 2
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VWF von Willebrand factor
WFS1 Wolfram syndrome 1 (wolframin)
WNT5B wingless-type MMTV integration site family, member 5B
WRN Werner syndrome, RecQ helicase-like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF7 zinc finger protein 7