diabetes, type 1 Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group immune (Genetic Association Database)
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Genes

280 genes associated with the disease diabetes, type 1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
ADA adenosine deaminase
ADD2 adducin 2 (beta)
ADK adenosine kinase
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AIF1 allograft inflammatory factor 1
AIRE autoimmune regulator
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
B2M beta-2-microglobulin
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BID BH3 interacting domain death agonist
BNC2 basonuclin 2
BTLA B and T lymphocyte associated
BTN3A2 butyrophilin, subfamily 3, member A2
BTNL2 butyrophilin-like 2
C10ORF2 chromosome 10 open reading frame 2
C1QTNF6 C1q and tumor necrosis factor related protein 6
C2 complement component 2
C5 complement component 5
C6ORF10 chromosome 6 open reading frame 10
C6ORF47 chromosome 6 open reading frame 47
CALD1 caldesmon 1
CAPSL calcyphosine-like
CARS cysteinyl-tRNA synthetase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD226 CD226 molecule
CD28 CD28 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD58 CD58 molecule
CD69 CD69 molecule
CDK2 cyclin-dependent kinase 2
CDK6 cyclin-dependent kinase 6
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CFB complement factor B
CLEC16A C-type lectin domain family 16, member A
CLIC1 chloride intracellular channel 1
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL11A2 collagen, type XI, alpha 2
CP ceruloplasmin (ferroxidase)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DBP D site of albumin promoter (albumin D-box) binding protein
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
ELMO1 engulfment and cell motility 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP2 fatty acid binding protein 2, intestinal
FADD Fas (TNFRSF6)-associated via death domain
FAM167A family with sequence similarity 167, member A
FOXP3 forkhead box P3
FRMD3 FERM domain containing 3
G6PC glucose-6-phosphatase, catalytic subunit
G6PD glucose-6-phosphate dehydrogenase
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCK glucokinase (hexokinase 4)
GHR growth hormone receptor
GLIS3 GLIS family zinc finger 3
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSC goosecoid homeobox
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HAVCR2 hepatitis A virus cellular receptor 2
HHEX hematopoietically expressed homeobox
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-G major histocompatibility complex, class I, G
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPG2 heparan sulfate proteoglycan 2
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IDE insulin-degrading enzyme
IFIH1 interferon induced with helicase C domain 1
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IKZF4 IKAROS family zinc finger 4 (Eos)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL18 interleukin 18
IL18RAP interleukin 18 receptor accessory protein
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL21 interleukin 21
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL7R interleukin 7 receptor
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KIF5A kinesin family member 5A
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
LEP leptin
LEPR leptin receptor
LPAR3 lysophosphatidic acid receptor 3
LPL lipoprotein lipase
LPP LIM domain containing preferred translocation partner in lipoma
LRP5 low density lipoprotein receptor-related protein 5
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MICA MHC class I polypeptide-related sequence A
MIOX myo-inositol oxygenase
MOG myelin oligodendrocyte glycoprotein
MSH5 mutS homolog 5
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYO9B myosin IXB
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NEUROD1 neuronal differentiation 1
NEUROD2 neuronal differentiation 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRP1 NLR family, pyrin domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH4 notch 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NRP1 neuropilin 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAX4 paired box 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD1 programmed cell death 1
PDCD2 programmed cell death 2
PDX1 pancreatic and duodenal homeobox 1
PGM1 phosphoglucomutase 1
PHOX2B paired-like homeobox 2b
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPT2 palmitoyl-protein thioesterase 2
PRKCQ protein kinase C, theta
PRRC2A proline-rich coiled-coil 2A
PRRT1 proline-rich transmembrane protein 1
PRSS16 protease, serine, 16 (thymus)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRN protein tyrosine phosphatase, receptor type, N
PYGL phosphorylase, glycogen, liver
RAB5B RAB5B, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RING1 ring finger protein 1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
SCN5A sodium channel, voltage gated, type V alpha subunit
SELL selectin L
SH2B3 SH2B adaptor protein 3
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SOD2 superoxide dismutase 2, mitochondrial
SORCS1 sortilin-related VPS10 domain containing receptor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
SUMO4 small ubiquitin-like modifier 4
SUOX sulfite oxidase
TADA1 transcriptional adaptor 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAGAP T-cell activation RhoGTPase activating protein
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBP TATA box binding protein
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
THY1 Thy-1 cell surface antigen
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMPO thymopoietin
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNXB tenascin XB
TRAF1 TNF receptor-associated factor 1
TXN thioredoxin
TYK2 tyrosine kinase 2
UBASH3A ubiquitin associated and SH3 domain containing A
UNC13B unc-13 homolog B (C. elegans)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WDR72 WD repeat domain 72
XYLT2 xylosyltransferase II
ZMIZ1 zinc finger, MIZ-type containing 1