dexibuprofen-6471 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dexibuprofen-6471 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ALPPL2 alkaline phosphatase, placental-like 2
ANAPC5 anaphase promoting complex subunit 5
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APC adenomatous polyposis coli
ATP10B ATPase, class V, type 10B
BHLHE40 basic helix-loop-helix family, member e40
BMP1 bone morphogenetic protein 1
C17ORF59 chromosome 17 open reading frame 59
C19ORF66 chromosome 19 open reading frame 66
CASR calcium-sensing receptor
CD101 CD101 molecule
CD52 CD52 molecule
CD58 CD58 molecule
CD6 CD6 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEP350 centrosomal protein 350kDa
CLIP2 CAP-GLY domain containing linker protein 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSNK1G1 casein kinase 1, gamma 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCAF11 DDB1 and CUL4 associated factor 11
DCC DCC netrin 1 receptor
DCT dopachrome tautomerase
DIEXF digestive organ expansion factor homolog (zebrafish)
DKFZP434L187 uncharacterized LOC26082
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNM3 dynamin 3
DPP4 dipeptidyl-peptidase 4
DXO decapping exoribonuclease
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERAP1 endoplasmic reticulum aminopeptidase 1
FBN2 fibrillin 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11292
FXYD2 FXYD domain containing ion transport regulator 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLP1R glucagon-like peptide 1 receptor
GRM8 glutamate receptor, metabotropic 8
HBS1L HBS1-like translational GTPase
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA7 homeobox A7
HPX hemopexin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITGB4 integrin, beta 4
JPH3 junctophilin 3
KLF13 Kruppel-like factor 13
LIG4 ligase IV, DNA, ATP-dependent
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LIN7A lin-7 homolog A (C. elegans)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPK11 mitogen-activated protein kinase 11
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MOB3B MOB kinase activator 3B
MTA1 metastasis associated 1
MTMR1 myotubularin related protein 1
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NADK NAD kinase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARVB parvin, beta
PAX5 paired box 5
PHC3 polyhomeotic homolog 3 (Drosophila)
POMT2 protein-O-mannosyltransferase 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRY PTPN13-like, Y-linked
PSG4 pregnancy specific beta-1-glycoprotein 4
RNF6 ring finger protein (C3H2C3 type) 6
RUNX1 runt-related transcription factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SETD8 SET domain containing (lysine methyltransferase) 8
SGCE sarcoglycan, epsilon
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35E2 solute carrier family 35, member E2
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMAD6 SMAD family member 6
SOCS6 suppressor of cytokine signaling 6
SSTR4 somatostatin receptor 4
TAAR5 trace amine associated receptor 5
TCF20 transcription factor 20 (AR1)
TMEM242 transmembrane protein 242
TRD T cell receptor delta locus
TRIP6 thyroid hormone receptor interactor 6
TUBGCP3 tubulin, gamma complex associated protein 3
ULBP2 UL16 binding protein 2
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR78 WD repeat domain 78
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF137P zinc finger protein 137, pseudogene
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACTL8 actin-like 8
ADM adrenomedullin
AFAP1 actin filament associated protein 1
AHCTF1 AT hook containing transcription factor 1
ALPK1 alpha-kinase 1
ANXA1 annexin A1
BAIAP3 BAI1-associated protein 3
C10ORF95 chromosome 10 open reading frame 95
C1ORF159 chromosome 1 open reading frame 159
C5AR2 complement component 5a receptor 2
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPRIN2 caprin family member 2
CDH10 cadherin 10, type 2 (T2-cadherin)
CEMIP cell migration inducing protein, hyaluronan binding
CLCN6 chloride channel, voltage-sensitive 6
CLDN17 claudin 17
CLIC2 chloride intracellular channel 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYGC crystallin, gamma C
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXXC4 CXXC finger protein 4
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFHD1 EF-hand domain family, member D1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM169A family with sequence similarity 169, member A
FBRS fibrosin
FSD1 fibronectin type III and SPRY domain containing 1
GID4 GID complex subunit 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRB7 growth factor receptor-bound protein 7
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H3I histone cluster 1, H3i
HIST1H4D histone cluster 1, H4d
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
IL12RB1 interleukin 12 receptor, beta 1
IL17RA interleukin 17 receptor A
INO80D INO80 complex subunit D
IPO8 importin 8
IQSEC2 IQ motif and Sec7 domain 2
ITPKB inositol-trisphosphate 3-kinase B
JRKL JRK-like
KIAA0125 KIAA0125
KIAA1456 KIAA1456
KLF2 Kruppel-like factor 2
KRBOX4 KRAB box domain containing 4
KREMEN2 kringle containing transmembrane protein 2
LIN7B lin-7 homolog B (C. elegans)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOXL3 lysyl oxidase-like 3
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAST3 microtubule associated serine/threonine kinase 3
MED31 mediator complex subunit 31
MYO1F myosin IF
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDE1 nudE neurodevelopment protein 1
NFE2L3 nuclear factor, erythroid 2-like 3
NPFFR1 neuropeptide FF receptor 1
NPR3 natriuretic peptide receptor 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAIP2B poly(A) binding protein interacting protein 2B
PBOV1 prostate and breast cancer overexpressed 1
PDIA3 protein disulfide isomerase family A, member 3
PHACTR4 phosphatase and actin regulator 4
PRDM14 PR domain containing 14
PROL1 proline rich, lacrimal 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAPSN receptor-associated protein of the synapse
RPL23AP32 ribosomal protein L23a pseudogene 32
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAG3 stromal antigen 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TARP TCR gamma alternate reading frame protein
TCHH trichohyalin
TESC tescalcin
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM132A transmembrane protein 132A
TMEM158 transmembrane protein 158 (gene/pseudogene)
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASH2 vasohibin 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZNF324 zinc finger protein 324
ZNF365 zinc finger protein 365
ZNF571 zinc finger protein 571
ZSWIM1 zinc finger, SWIM-type containing 1