desipramine-3212 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the desipramine-3212 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANK1 ankyrin 1, erythrocytic
APP amyloid beta (A4) precursor protein
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID1A AT rich interactive domain 1A (SWI-like)
ARMCX2 armadillo repeat containing, X-linked 2
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BGN biglycan
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C14ORF1 chromosome 14 open reading frame 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCR4 chemokine (C-C motif) receptor 4
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK18 cyclin-dependent kinase 18
CHD5 chromodomain helicase DNA binding protein 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPB2 carboxypeptidase B2 (plasma)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTF1 cardiotrophin 1
DIEXF digestive organ expansion factor homolog (zebrafish)
DIO2 deiodinase, iodothyronine, type II
DLX2 distal-less homeobox 2
DOCK9 dedicator of cytokinesis 9
DUSP4 dual specificity phosphatase 4
E2F5 E2F transcription factor 5, p130-binding
EFNB3 ephrin-B3
EMC1 ER membrane protein complex subunit 1
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
FBXO40 F-box protein 40
FCMR Fc fragment of IgM receptor
FGD1 FYVE, RhoGEF and PH domain containing 1
FPR1 formyl peptide receptor 1
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GPATCH4 G patch domain containing 4
GPER1 G protein-coupled estrogen receptor 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
IL12B interleukin 12B
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRT17 keratin 17, type I
LDHAL6B lactate dehydrogenase A-like 6B
LPIN1 lipin 1
MAL mal, T-cell differentiation protein
MBNL1 muscleblind-like splicing regulator 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPZL1 myelin protein zero-like 1
MTMR1 myotubularin related protein 1
MVK mevalonate kinase
NDRG2 NDRG family member 2
NEFL neurofilament, light polypeptide
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPR2 natriuretic peptide receptor 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PITX1 paired-like homeodomain 1
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G3 phospholipase A2, group III
PLXNC1 plexin C1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PROL1 proline rich, lacrimal 1
PSG4 pregnancy specific beta-1-glycoprotein 4
RAB3D RAB3D, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
RPL10 ribosomal protein L10
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1 runt-related transcription factor 1
SEC24D SEC24 family member D
SETD8 SET domain containing (lysine methyltransferase) 8
SHOX2 short stature homeobox 2
SIRT4 sirtuin 4
SIRT5 sirtuin 5
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35E2 solute carrier family 35, member E2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SLMO1 slowmo homolog 1 (Drosophila)
SMAD3 SMAD family member 3
SMG6 SMG6 nonsense mediated mRNA decay factor
SORT1 sortilin 1
SS18 synovial sarcoma translocation, chromosome 18
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCP11L1 t-complex 11, testis-specific-like 1
TLE4 transducin-like enhancer of split 4
TLK1 tousled-like kinase 1
TMEM45A transmembrane protein 45A
TMEM63A transmembrane protein 63A
TYMP thymidine phosphorylase
UBE2I ubiquitin-conjugating enzyme E2I
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF484 zinc finger protein 484
ZNF614 zinc finger protein 614

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARL15 ADP-ribosylation factor-like 15
BCL9 B-cell CLL/lymphoma 9
C2ORF44 chromosome 2 open reading frame 44
CBX8 chromobox homolog 8
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
CRYGC crystallin, gamma C
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNM1 dynamin 1
DSCAM Down syndrome cell adhesion molecule
EDAR ectodysplasin A receptor
F2R coagulation factor II (thrombin) receptor
FBXW12 F-box and WD repeat domain containing 12
GBP2 guanylate binding protein 2, interferon-inducible
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPATCH2L G patch domain containing 2-like
GPC3 glypican 3
GPR1 G protein-coupled receptor 1
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AI histone cluster 1, H2ai
HIST1H2AK histone cluster 1, H2ak
HIST1H4D histone cluster 1, H4d
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMOX1 heme oxygenase 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC11 homeobox C11
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL4R interleukin 4 receptor
IPO8 importin 8
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIF13B kinesin family member 13B
LIME1 Lck interacting transmembrane adaptor 1
LIN7A lin-7 homolog A (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYZ lysozyme
MATK megakaryocyte-associated tyrosine kinase
MBNL3 muscleblind-like splicing regulator 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
MRPS18C mitochondrial ribosomal protein S18C
MT1H metallothionein 1H
MTHFSD methenyltetrahydrofolate synthetase domain containing
NDRG4 NDRG family member 4
NIPAL2 NIPA-like domain containing 2
NLRX1 NLR family member X1
NXPH4 neurexophilin 4
OLFML3 olfactomedin-like 3
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLTP phospholipid transfer protein
QPCTL glutaminyl-peptide cyclotransferase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS20 regulator of G-protein signaling 20
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SECTM1 secreted and transmembrane 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A8 solute carrier family 12, member 8
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX3 SRY (sex determining region Y)-box 3
SYCP2 synaptonemal complex protein 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TEP1 telomerase-associated protein 1
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TM6SF1 transmembrane 6 superfamily member 1
TM7SF3 transmembrane 7 superfamily member 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF2 TNF receptor-associated factor 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTC23 tetratricopeptide repeat domain 23
TUBA3D tubulin, alpha 3d
USP20 ubiquitin specific peptidase 20
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF329 zinc finger protein 329
ZNF34 zinc finger protein 34
ZNF365 zinc finger protein 365
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652
ZNF701 zinc finger protein 701