dense core granule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. (Gene Ontology, GO_0031045)
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Genes

177 proteins co-occuring with the dense core granule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SCG2 secretogranin II 1.97698
CHGA chromogranin A 1.95302
NPS neuropeptide S 1.81176
SYP synaptophysin 1.71808
ENO2 enolase 2 (gamma, neuronal) 1.63896
CHGB chromogranin B 1.62236
TAC1 tachykinin, precursor 1 1.36362
NPY neuropeptide Y 1.36362
CALCA calcitonin-related polypeptide alpha 1.36088
RAB3A RAB3A, member RAS oncogene family 1.32546
TH tyrosine hydroxylase 1.29799
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.22101
VGF VGF nerve growth factor inducible 1.20395
SYTL4 synaptotagmin-like 4 1.19365
CAPS2 calcyphosine 2 1.17106
CADPS2 Ca++-dependent secretion activator 2 1.16235
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.15057
RAB27A RAB27A, member RAS oncogene family 1.12858
PDYN prodynorphin 1.11735
SYT1 synaptotagmin I 1.10664
SYT7 synaptotagmin VII 1.10511
STXBP1 syntaxin binding protein 1 1.06802
POMC proopiomelanocortin 1.066
SYT4 synaptotagmin IV 1.03829
SST somatostatin 1.01536
B3GAT1 beta-1,3-glucuronyltransferase 1 1.01139
SYT9 synaptotagmin IX 1.00843
RPH3A rabphilin 3A 1.00399
INS insulin 0.971297
PAM peptidylglycine alpha-amidating monooxygenase 0.96792
GRP gastrin-releasing peptide 0.960707
SCAMP2 secretory carrier membrane protein 2 0.935016
NSF N-ethylmaleimide-sensitive factor 0.925135
UNC13A unc-13 homolog A (C. elegans) 0.924666
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.916243
CPE carboxypeptidase E 0.912977
CADPS Ca++-dependent secretion activator 0.906926
NGF nerve growth factor (beta polypeptide) 0.891631
UNC13B unc-13 homolog B (C. elegans) 0.881016
BDNF brain-derived neurotrophic factor 0.806148
PNMT phenylethanolamine N-methyltransferase 0.794687
RAB2A RAB2A, member RAS oncogene family 0.794229
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.794229
RAB3D RAB3D, member RAS oncogene family 0.793313
CRH corticotropin releasing hormone 0.739614
GAL galanin/GMAP prepropeptide 0.711908
CGB5 chorionic gonadotropin, beta polypeptide 5 0.704831
CGB7 chorionic gonadotropin, beta polypeptide 7 0.704831
VIP vasoactive intestinal peptide 0.702626
SNAP23 synaptosomal-associated protein, 23kDa 0.702185
STX1A syntaxin 1A (brain) 0.701304
CGB chorionic gonadotropin, beta polypeptide 0.694709
NTS neurotensin 0.694709
CGB8 chorionic gonadotropin, beta polypeptide 8 0.692078
SYN1 synapsin I 0.65259
CCK cholecystokinin 0.65001
RAB33A RAB33A, member RAS oncogene family 0.640145
CD99 CD99 molecule 0.638434
GNAS GNAS complex locus 0.636723
SCRG1 stimulator of chondrogenesis 1 0.634159
SYT3 synaptotagmin III 0.634159
RAB3B RAB3B, member RAS oncogene family 0.611625
GAST gastrin 0.607395
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.603596
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.58134
SNAPIN SNAP-associated protein 0.577164
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.564677
ICA1 islet cell autoantigen 1, 69kDa 0.54936
SCG3 secretogranin III 0.546472
PTPRN protein tyrosine phosphatase, receptor type, N 0.545648
SYT5 synaptotagmin V 0.545648
RAB3C RAB3C, member RAS oncogene family 0.541117
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.535361
NBEA neurobeachin 0.519389
TRH thyrotropin-releasing hormone 0.5149
RIMS2 regulating synaptic membrane exocytosis 2 0.509197
RAB41 RAB41, member RAS oncogene family 0.50757
PCSK2 proprotein convertase subtilisin/kexin type 2 0.505944
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.505131
OPRM1 opioid receptor, mu 1 0.501881
PPCDC phosphopantothenoylcysteine decarboxylase 0.4958
NTF3 neurotrophin 3 0.47442
KIF1A kinesin family member 1A 0.450438
STX6 syntaxin 6 0.45004
STXBP2 syntaxin binding protein 2 0.442104
CABP7 calcium binding protein 7 0.437751
NCAM1 neural cell adhesion molecule 1 0.426711
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.425531
BOD1 biorientation of chromosomes in cell division 1 0.419644
SAC3D1 SAC3 domain containing 1 0.414555
AMPH amphiphysin 0.410259
SCAMP1 secretory carrier membrane protein 1 0.40247
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 0.398975
AVP arginine vasopressin 0.393936
SCAMP5 secretory carrier membrane protein 5 0.382354
NPPA natriuretic peptide A 0.381969
SYTL5 synaptotagmin-like 5 0.379276
FOXM1 forkhead box M1 0.378507
UHMK1 U2AF homology motif (UHM) kinase 1 0.372749
STXBP5 syntaxin binding protein 5 (tomosyn) 0.372749
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.372366
PPY pancreatic polypeptide 0.371982
SNX19 sorting nexin 19 0.367388
PLAT plasminogen activator, tissue 0.365095
BSN bassoon presynaptic cytomatrix protein 0.363567
RAB37 RAB37, member RAS oncogene family 0.363185
ACHE acetylcholinesterase (Yt blood group) 0.360133
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.358609
REST RE1-silencing transcription factor 0.351762
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.349105
CALN1 calneuron 1 0.341907
CHAT choline O-acetyltransferase 0.336996
GCG glucagon 0.333979
EXPH5 exophilin 5 0.333979
VAMP3 vesicle-associated membrane protein 3 0.327581
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.325702
PCSK1 proprotein convertase subtilisin/kexin type 1 0.320826
INSM2 insulinoma-associated 2 0.320077
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.319328
ARF4 ADP-ribosylation factor 4 0.317082
CARTPT CART prepropeptide 0.308494
RAB43 RAB43, member RAS oncogene family 0.308122
OPRK1 opioid receptor, kappa 1 0.303283
RALB v-ral simian leukemia viral oncogene homolog B 0.30254
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.294007
RESP18 regulated endocrine-specific protein 18 0.290678
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 0.289569
ARF5 ADP-ribosylation factor 5 0.28846
VAMP4 vesicle-associated membrane protein 4 0.286245
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.274101
NMS neuromedin S 0.271167
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.26239
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.261296
NCS1 neuronal calcium sensor 1 0.259473
RAB22A RAB22A, member RAS oncogene family 0.256925
SLC7A4 solute carrier family 7, member 4 0.256925
STX2 syntaxin 2 0.255107
RAB27B RAB27B, member RAS oncogene family 0.254017
PHF21A PHD finger protein 21A 0.254017
SCAMP3 secretory carrier membrane protein 3 0.250389
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.250026
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.248578
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.245685
ARF6 ADP-ribosylation factor 6 0.242797
DNM1 dynamin 1 0.242437
IL2RG interleukin 2 receptor, gamma 0.240996
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.239916
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.217511
RCAN2 regulator of calcineurin 2 0.214714
PRICKLE1 prickle homolog 1 (Drosophila) 0.212974
TAC3 tachykinin 3 0.208481
SCG5 secretogranin V 0.207451
OXT oxytocin/neurophysin I prepropeptide 0.206082
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.199993
ZFYVE26 zinc finger, FYVE domain containing 26 0.197993
BTC betacellulin 0.197662
CCL21 chemokine (C-C motif) ligand 21 0.189857
RAB8A RAB8A, member RAS oncogene family 0.18859
CDC16 cell division cycle 16 0.18702
TECTA tectorin alpha 0.183328
PLD1 phospholipase D1, phosphatidylcholine-specific 0.181227
ETV1 ets variant 1 0.178299
SYT2 synaptotagmin II 0.17141
HCRT hypocretin (orexin) neuropeptide precursor 0.170371
MADD MAP-kinase activating death domain 0.169604
DPP8 dipeptidyl-peptidase 8 0.167856
EWSR1 EWS RNA-binding protein 1 0.167611
TFDP3 transcription factor Dp family, member 3 0.167366
TGOLN2 trans-golgi network protein 2 0.167366
DPP9 dipeptidyl-peptidase 9 0.166643
FURIN furin (paired basic amino acid cleaving enzyme) 0.166643
PNOC prepronociceptin 0.163865
FZD8 frizzled class receptor 8 0.16298
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.162763
REN renin 0.159658
MYO5A myosin VA (heavy chain 12, myoxin) 0.159658
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.158502