dengue shock syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth. (Human Disease Ontology, DOID_0050125)
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Genes

120 genes co-occuring with the disease dengue shock syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.33283
CLEC5A C-type lectin domain family 5, member A 1.19964
ERVW-1 endogenous retrovirus group W, member 1 1.08454
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 1.08327
PLCE1 phospholipase C, epsilon 1 1.05177
AVIL advillin 1.01976
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.9898
ATR ATR serine/threonine kinase 0.967502
MICB MHC class I polypeptide-related sequence B 0.940364
CAPRIN1 cell cycle associated protein 1 0.878195
KRAS Kirsten rat sarcoma viral oncogene homolog 0.868368
INTS8 integrator complex subunit 8 0.86714
STAT2 signal transducer and activator of transcription 2, 113kDa 0.847898
ICT1 immature colon carcinoma transcript 1 0.811001
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.750457
F3 coagulation factor III (thromboplastin, tissue factor) 0.75005
THBD thrombomodulin 0.749237
F2 coagulation factor II (thrombin) 0.740705
TNF tumor necrosis factor 0.703134
RAB18 RAB18, member RAS oncogene family 0.702732
VEZF1 vascular endothelial zinc finger 1 0.702732
KIF5B kinesin family member 5B 0.696707
SERF1B small EDRK-rich factor 1B (centromeric) 0.692697
SERF1A small EDRK-rich factor 1A (telomeric) 0.692697
CD209 CD209 molecule 0.666755
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.663181
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 0.661197
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.635921
DAXX death-domain associated protein 0.63042
ALB albumin 0.62728
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.624143
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.615921
PRNT prion protein (testis specific) 0.613183
TJP1 tight junction protein 1 0.610448
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.606152
STAT1 signal transducer and activator of transcription 1, 91kDa 0.582384
CDH5 cadherin 5, type 2 (vascular endothelium) 0.578883
ARHGAP35 Rho GTPase activating protein 35 0.57655
BATF2 basic leucine zipper transcription factor, ATF-like 2 0.56722
CLEC4M C-type lectin domain family 4, member M 0.565666
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.540829
C5AR1 complement component 5a receptor 1 0.537344
UBA1 ubiquitin-like modifier activating enzyme 1 0.535022
AHRR aryl-hydrocarbon receptor repressor 0.524588
IRF7 interferon regulatory factor 7 0.518805
DMRT1 doublesex and mab-3 related transcription factor 1 0.516494
GDF2 growth differentiation factor 2 0.515725
ICAM3 intercellular adhesion molecule 3 0.497321
PCDH8 protocadherin 8 0.487027
IL1B interleukin 1, beta 0.479807
IRF9 interferon regulatory factor 9 0.466172
EIF5A eukaryotic translation initiation factor 5A 0.449194
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.447687
SYT1 synaptotagmin I 0.446182
HLA-C major histocompatibility complex, class I, C 0.436402
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.436026
IRF3 interferon regulatory factor 3 0.431894
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.416521
HPSE2 heparanase 2 (inactive) 0.416521
CCL5 chemokine (C-C motif) ligand 5 0.415773
IFNA1 interferon, alpha 1 0.403064
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.400453
CXCL10 chemokine (C-X-C motif) ligand 10 0.396725
CD4 CD4 molecule 0.392257
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.386679
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.384079
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.380739
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.374809
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.357814
IRF1 interferon regulatory factor 1 0.352291
DCN decorin 0.351555
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.335778
TYROBP TYRO protein tyrosine kinase binding protein 0.329565
PLG plasminogen 0.323365
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.318272
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.313552
ISG20 interferon stimulated exonuclease gene 20kDa 0.312464
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.30848
FXYD1 FXYD domain containing ion transport regulator 1 0.308118
ANGPT2 angiopoietin 2 0.307757
IL6 interleukin 6 0.301615
ANGPT1 angiopoietin 1 0.299812
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.292257
IL1RN interleukin 1 receptor antagonist 0.281868
CD83 CD83 molecule 0.279011
FGA fibrinogen alpha chain 0.278297
HES5 hes family bHLH transcription factor 5 0.278297
HLA-A major histocompatibility complex, class I, A 0.272597
GNLY granulysin 0.272241
IL10 interleukin 10 0.27153
GREM2 gremlin 2, DAN family BMP antagonist 0.261599
PTGIS prostaglandin I2 (prostacyclin) synthase 0.248554
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.246098
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.240847
PTGDR prostaglandin D2 receptor (DP) 0.237357
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.237357
PLAT plasminogen activator, tissue 0.228679
PROCR protein C receptor, endothelial 0.224884
MTDH metadherin 0.21974
ICAM1 intercellular adhesion molecule 1 0.219398
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.216332
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.208245
KAT2B K(lysine) acetyltransferase 2B 0.206913
ASCL1 achaete-scute family bHLH transcription factor 1 0.201962
HMGB1 high mobility group box 1 0.201635
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.200006
PLA2G10 phospholipase A2, group X 0.198709
FDPS farnesyl diphosphate synthase 0.194548
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.193915
CD70 CD70 molecule 0.191719
MAP2K1 mitogen-activated protein kinase kinase 1 0.191408
PNMT phenylethanolamine N-methyltransferase 0.188326
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.187113
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.175679
MRC1 mannose receptor, C type 1 0.166319
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.165874
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.165655
PDGFB platelet-derived growth factor beta polypeptide 0.165001
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.161139
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.158605