delayed cellular replicative senescence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division (Mammalian Phenotype Ontology, MP_0008009)
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9 gene mutations causing the delayed cellular replicative senescence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
ING1 inhibitor of growth family, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MTF2 metal response element binding transcription factor 2
NONO non-POU domain containing, octamer-binding
SIRT2 sirtuin 2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
TP53 tumor protein p53