dehydrocholic acid-2023 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the dehydrocholic acid-2023 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADK adenosine kinase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
BCL7A B-cell CLL/lymphoma 7A
C1ORF109 chromosome 1 open reading frame 109
C1ORF61 chromosome 1 open reading frame 61
C22ORF24 chromosome 22 open reading frame 24
CACFD1 calcium channel flower domain containing 1
CAST calpastatin
CCPG1 cell cycle progression 1
CD101 CD101 molecule
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CD5 CD5 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEP152 centrosomal protein 152kDa
CETN1 centrin, EF-hand protein, 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC5 chloride intracellular channel 5
COG5 component of oligomeric golgi complex 5
CREB3 cAMP responsive element binding protein 3
CTSS cathepsin S
CUL3 cullin 3
DDR1 discoidin domain receptor tyrosine kinase 1
DERL1 derlin 1
DIAPH1 diaphanous-related formin 1
DIEXF digestive organ expansion factor homolog (zebrafish)
DND1 DND microRNA-mediated repression inhibitor 1
DSN1 DSN1, MIS12 kinetochore complex component
DST dystonin
EIF4E eukaryotic translation initiation factor 4E
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ELMO2 engulfment and cell motility 2
EPHB4 EPH receptor B4
FADS2 fatty acid desaturase 2
FCHO1 FCH domain only 1
FOSL1 FOS-like antigen 1
FYB FYN binding protein
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GPX2 glutathione peroxidase 2
HIRA histone cell cycle regulator
HIST1H3E histone cluster 1, H3e
HNF1A HNF1 homeobox A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITSN1 intersectin 1 (SH3 domain protein)
KIFC1 kinesin family member C1
KLHL20 kelch-like family member 20
LPP LIM domain containing preferred translocation partner in lipoma
LRRN2 leucine rich repeat neuronal 2
MAPK13 mitogen-activated protein kinase 13
MFSD11 major facilitator superfamily domain containing 11
MSH3 mutS homolog 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NUP160 nucleoporin 160kDa
PAPPA2 pappalysin 2
PARG poly (ADP-ribose) glycohydrolase
PBX2 pre-B-cell leukemia homeobox 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB2 phospholipase C, beta 2
PLS1 plastin 1
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRPH2 peripherin 2 (retinal degeneration, slow)
PSG6 pregnancy specific beta-1-glycoprotein 6
RAD21 RAD21 homolog (S. pombe)
RAD23B RAD23 homolog B (S. cerevisiae)
RBBP5 retinoblastoma binding protein 5
RCAN1 regulator of calcineurin 1
RNF208 ring finger protein 208
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SERINC5 serine incorporator 5
SIRT5 sirtuin 5
SLC22A18 solute carrier family 22, member 18
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPIDR scaffolding protein involved in DNA repair
SPN sialophorin
SPTSSA serine palmitoyltransferase, small subunit A
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRSF11 serine/arginine-rich splicing factor 11
STIM1 stromal interaction molecule 1
STMN1 stathmin 1
SUGP1 SURP and G patch domain containing 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TCP11L1 t-complex 11, testis-specific-like 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPSG1 tryptase gamma 1
TXN2 thioredoxin 2
UEVLD UEV and lactate/malate dehyrogenase domains
WDR19 WD repeat domain 19
YIPF2 Yip1 domain family, member 2
ZC4H2 zinc finger, C4H2 domain containing
ZNF280D zinc finger protein 280D
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADM2 adrenomedullin 2
AEN apoptosis enhancing nuclease
ALPK1 alpha-kinase 1
ANXA6 annexin A6
AQP2 aquaporin 2 (collecting duct)
ARG1 arginase 1
ASAP1-IT1 ASAP1 intronic transcript 1
ASCC2 activating signal cointegrator 1 complex subunit 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCKDK branched chain ketoacid dehydrogenase kinase
BCL7C B-cell CLL/lymphoma 7C
CBR1 carbonyl reductase 1
CCNL2 cyclin L2
CDCA3 cell division cycle associated 3
CEP72 centrosomal protein 72kDa
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLK3 CDC-like kinase 3
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CPTP ceramide-1-phosphate transfer protein
CTAGE9 CTAGE family, member 9
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DDB2 damage-specific DNA binding protein 2, 48kDa
EDAR ectodysplasin A receptor
EDC3 enhancer of mRNA decapping 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM193B family with sequence similarity 193, member B
FBXL15 F-box and leucine-rich repeat protein 15
FKBP2 FK506 binding protein 2, 13kDa
GAB2 GRB2-associated binding protein 2
GALT galactose-1-phosphate uridylyltransferase
GMPPA GDP-mannose pyrophosphorylase A
GPALPP1 GPALPP motifs containing 1
GSTM5 glutathione S-transferase mu 5
H2BFS H2B histone family, member S (pseudogene)
HAGH hydroxyacylglutathione hydrolase
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL4R interleukin 4 receptor
ILK integrin-linked kinase
INA internexin neuronal intermediate filament protein, alpha
IP6K1 inositol hexakisphosphate kinase 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIFAP3 kinesin-associated protein 3
KRI1 KRI1 homolog (S. cerevisiae)
LGALS9 lectin, galactoside-binding, soluble, 9
LRRC42 leucine rich repeat containing 42
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LZTR1 leucine-zipper-like transcription regulator 1
MAGOHB mago-nashi homolog B (Drosophila)
MICALL2 MICAL-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MXRA8 matrix-remodelling associated 8
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NCKAP1L NCK-associated protein 1-like
NPPA natriuretic peptide A
NSD1 nuclear receptor binding SET domain protein 1
NUBP2 nucleotide binding protein 2
NUP93 nucleoporin 93kDa
NVL nuclear VCP-like
OR1F1 olfactory receptor, family 1, subfamily F, member 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALM paralemmin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX12 peroxisomal biogenesis factor 12
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PMEL premelanosome protein
PPDPF pancreatic progenitor cell differentiation and proliferation factor
RAB5C RAB5C, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RAD9A RAD9 homolog A (S. pombe)
RBM47 RNA binding motif protein 47
RBMS3 RNA binding motif, single stranded interacting protein 3
RHBDD3 rhomboid domain containing 3
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
TEX40 testis expressed 40
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM14A transmembrane protein 14A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM214 transmembrane protein 214
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TUBA4B tubulin, alpha 4b
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCKL1 uridine-cytidine kinase 1-like 1
UNKL unkempt family zinc finger-like
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
YY2 YY2 transcription factor
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF33B zinc finger protein 33B
ZNF408 zinc finger protein 408