deferoxamine-460 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the deferoxamine-460 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ACAN aggrecan
ADAM8 ADAM metallopeptidase domain 8
ADM adrenomedullin
ALOX15B arachidonate 15-lipoxygenase, type B
ANGPTL4 angiopoietin-like 4
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APAF1 apoptotic peptidase activating factor 1
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARSA arylsulfatase A
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C10ORF10 chromosome 10 open reading frame 10
CAMKV CaM kinase-like vesicle-associated
CCNE2 cyclin E2
CD22 CD22 molecule
CLU clusterin
CNTD2 cyclin N-terminal domain containing 2
COX5B cytochrome c oxidase subunit Vb
CPE carboxypeptidase E
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSRP2 cysteine and glycine-rich protein 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDIT4 DNA-damage-inducible transcript 4
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFNA3 ephrin-A3
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
FAM162A family with sequence similarity 162, member A
FOLR1 folate receptor 1 (adult)
GPER1 G protein-coupled estrogen receptor 1
GPRC5C G protein-coupled receptor, class C, group 5, member C
GUCA1A guanylate cyclase activator 1A (retina)
GUK1 guanylate kinase 1
H2AFY2 H2A histone family, member Y2
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-C major histocompatibility complex, class I, C
HMOX2 heme oxygenase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INSIG2 insulin induced gene 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MAP2K1 mitogen-activated protein kinase kinase 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDN necdin, melanoma antigen (MAGE) family member
NDRG1 N-myc downstream regulated 1
NIPAL2 NIPA-like domain containing 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
RARG retinoic acid receptor, gamma
RNF24 ring finger protein 24
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SAR1A secretion associated, Ras related GTPase 1A
SIK2 salt-inducible kinase 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SPN sialophorin
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX2 syntaxin 2
TBC1D2B TBC1 domain family, member 2B
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TMC6 transmembrane channel-like 6
TMCO6 transmembrane and coiled-coil domains 6
TMEM161A transmembrane protein 161A
TRADD TNFRSF1A-associated via death domain
TREX1 three prime repair exonuclease 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN32 tetraspanin 32
TXN thioredoxin
UBOX5 U-box domain containing 5
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR19 WD repeat domain 19
ZEB1 zinc finger E-box binding homeobox 1
ZFX zinc finger protein, X-linked
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APOC4 apolipoprotein C-IV
ARHGAP5 Rho GTPase activating protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG2A autophagy related 2A
C17ORF70 chromosome 17 open reading frame 70
CAAP1 caspase activity and apoptosis inhibitor 1
CDC25B cell division cycle 25B
CDCA8 cell division cycle associated 8
CDK7 cyclin-dependent kinase 7
CISH cytokine inducible SH2-containing protein
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COMMD8 COMM domain containing 8
CRNKL1 crooked neck pre-mRNA splicing factor 1
CTSE cathepsin E
CXADR coxsackie virus and adenovirus receptor
DBF4 DBF4 zinc finger
DIXDC1 DIX domain containing 1
ERBB2IP erbb2 interacting protein
ERN2 endoplasmic reticulum to nucleus signaling 2
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
FBXL6 F-box and leucine-rich repeat protein 6
FIP1L1 factor interacting with PAPOLA and CPSF1
FJX1 four jointed box 1 (Drosophila)
FKBP10 FK506 binding protein 10, 65 kDa
GAB2 GRB2-associated binding protein 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATAD2A GATA zinc finger domain containing 2A
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GEM GTP binding protein overexpressed in skeletal muscle
GOLPH3 golgi phosphoprotein 3 (coat-protein)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H4C histone cluster 1, H4c
HIST1H4J histone cluster 1, H4j
IER5 immediate early response 5
IGKV1D-13 immunoglobulin kappa variable 1D-13
INHBC inhibin, beta C
INTS8 integrator complex subunit 8
IRS1 insulin receptor substrate 1
KIF14 kinesin family member 14
KIFC1 kinesin family member C1
LMNB1 lamin B1
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRP5 low density lipoprotein receptor-related protein 5
LRRC15 leucine rich repeat containing 15
MFGE8 milk fat globule-EGF factor 8 protein
MTG1 mitochondrial ribosome-associated GTPase 1
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NPTX1 neuronal pentraxin I
NR3C2 nuclear receptor subfamily 3, group C, member 2
PEF1 penta-EF-hand domain containing 1
PF4 platelet factor 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PLAU plasminogen activator, urokinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POR P450 (cytochrome) oxidoreductase
PRSS23 protease, serine, 23
QDPR quinoid dihydropteridine reductase
R3HDM2 R3H domain containing 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF103 ring finger protein 103
RNF141 ring finger protein 141
RNF185 ring finger protein 185
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHARPIN SHANK-associated RH domain interactor
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SOX21 SRY (sex determining region Y)-box 21
SSUH2 ssu-2 homolog (C. elegans)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SUSD4 sushi domain containing 4
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TASP1 taspase, threonine aspartase, 1
TGS1 trimethylguanosine synthase 1
TJP2 tight junction protein 2
TRIM58 tripartite motif containing 58
TTC27 tetratricopeptide repeat domain 27
TTC4 tetratricopeptide repeat domain 4
TULP2 tubby like protein 2
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VANGL1 VANGL planar cell polarity protein 1
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZBTB38 zinc finger and BTB domain containing 38
ZNF274 zinc finger protein 274
ZNF322P1 zinc finger protein 322 pseudogene 1