decreased triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver (Mammalian Phenotype Ontology, MP_0005318)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005318
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Genes

181 gene mutations causing the decreased triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABHD5 abhydrolase domain containing 5
ACOT13 acyl-CoA thioesterase 13
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGRP agouti related neuropeptide
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMACR alpha-methylacyl-CoA racemase
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOF apolipoprotein F
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARRDC3 arrestin domain containing 3
BAG3 BCL2-associated athanogene 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF80 chromosome 19 open reading frame 80
C3 complement component 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAPZB capping protein (actin filament) muscle Z-line, beta
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEA cell death-inducing DFFA-like effector a
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLPS colipase, pancreatic
CNOT3 CCR4-NOT transcription complex, subunit 3
CRBN cereblon
CREBBP CREB binding protein
CRHR2 corticotropin releasing hormone receptor 2
CXCL14 chemokine (C-X-C motif) ligand 14
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
DLL1 delta-like 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMOD1 ELMO/CED-12 domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FABP1 fatty acid binding protein 1, liver
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FAM117B family with sequence similarity 117, member B
FFAR1 free fatty acid receptor 1
FFAR3 free fatty acid receptor 3
FGF23 fibroblast growth factor 23
FOXA1 forkhead box A1
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
G6PC2 glucose-6-phosphatase, catalytic, 2
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCGR glucagon receptor
GHR growth hormone receptor
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSTK1 glutathione S-transferase kappa 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HNF4A hepatocyte nuclear factor 4, alpha
HPN hepsin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGFBP3 insulin-like growth factor binding protein 3
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSIG1 insulin induced gene 1
JAK1 Janus kinase 1
JUND jun D proto-oncogene
KISS1R KISS1 receptor
KLB klotho beta
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LIF leukemia inhibitory factor
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LPIN1 lipin 1
LRP6 low density lipoprotein receptor-related protein 6
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MC3R melanocortin 3 receptor
MFSD2A major facilitator superfamily domain containing 2A
MGLL monoglyceride lipase
MIA2 melanoma inhibitory activity 2
MIR122 microRNA 122
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
MTTP microsomal triglyceride transfer protein
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NEGR1 neuronal growth regulator 1
NKX2-3 NK2 homeobox 3
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NXPH4 neurexophilin 4
OED Oregon eye disease
OSTM1 osteopetrosis associated transmembrane protein 1
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNA phosphatidylinositol transfer protein, alpha
PITX3 paired-like homeodomain 3
PLA2G12B phospholipase A2, group XIIB
PLIN2 perilipin 2
PLIN4 perilipin 4
PLIN5 perilipin 5
PMCH pro-melanin-concentrating hormone
PNPLA2 patatin-like phospholipase domain containing 2
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRKG1 protein kinase, cGMP-dependent, type I
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RETN resistin
RNF10 ring finger protein 10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SGMS2 sphingomyelin synthase 2
SGOL2 shugoshin-like 2 (S. pombe)
SIK3 SIK family kinase 3
SIRT7 sirtuin 7
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC38A10 solute carrier family 38, member 10
SLC51A solute carrier family 51, alpha subunit
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOCS2 suppressor of cytokine signaling 2
SORBS1 sorbin and SH3 domain containing 1
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
SREBF1 sterol regulatory element binding transcription factor 1
SSFA2 sperm specific antigen 2
STARD10 StAR-related lipid transfer (START) domain containing 10
THRB thyroid hormone receptor, beta
THRSP thyroid hormone responsive
TLR4 toll-like receptor 4
TMEM167A transmembrane protein 167A
TNF tumor necrosis factor
TRPC3 transient receptor potential cation channel, subfamily C, member 3
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
USHBP1 Usher syndrome 1C binding protein 1
WWOX WW domain containing oxidoreductase