decreased susceptibility to type i hypersensitivity reaction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks (Mammalian Phenotype Ontology, MP_0005597)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005597
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Genes

35 gene mutations causing the decreased susceptibility to type i hypersensitivity reaction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCRL2 chemokine (C-C motif) receptor-like 2
CD81 CD81 molecule
CPA3 carboxypeptidase A3 (mast cell)
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
ECM1 extracellular matrix protein 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GAB2 GRB2-associated binding protein 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LBP lipopolysaccharide binding protein
LTA4H leukotriene A4 hydrolase
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
ORAI1 ORAI calcium release-activated calcium modulator 1
PLA2G3 phospholipase A2, group III
PTGDR prostaglandin D2 receptor (DP)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRC protein tyrosine phosphatase, receptor type, C
RHOH ras homolog family member H
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
STIM1 stromal interaction molecule 1
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
VIPR2 vasoactive intestinal peptide receptor 2