decreased susceptibility to induced joint inflammation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced or absent inflammatory response in the joints due to chemical or mechanical agents (Mammalian Phenotype Ontology, MP_0003079)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003079
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Genes

54 gene mutations causing the decreased susceptibility to induced joint inflammation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAN aggrecan
ADAM8 ADAM metallopeptidase domain 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIF1 allograft inflammatory factor 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BMX BMX non-receptor tyrosine kinase
C3 complement component 3
CD1D CD1d molecule
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFP complement factor properdin
CLEC5A C-type lectin domain family 5, member A
CTSS cathepsin S
CXCR2 chemokine (C-X-C motif) receptor 2
DUSP2 dual specificity phosphatase 2
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
GPSM3 G-protein signaling modulator 3
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IRF1 interferon regulatory factor 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LTA lymphotoxin alpha
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD2 nucleotide-binding oligomerization domain containing 2
PGLYRP2 peptidoglycan recognition protein 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASGRP4 RAS guanyl releasing protein 4
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TPSAB1 tryptase alpha/beta 1
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa