decreased susceptibility to endotoxin shock Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death (Mammalian Phenotype Ontology, MP_0008734)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008734
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Genes

59 gene mutations causing the decreased susceptibility to endotoxin shock phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APCS amyloid P component, serum
BDKRB1 bradykinin receptor B1
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCKBR cholecystokinin B receptor
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLIC4 chloride intracellular channel 4
CXCL6 chemokine (C-X-C motif) ligand 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
GCA grancalcin, EF-hand calcium binding protein
ICAM1 intercellular adhesion molecule 1
IFNGR1 interferon gamma receptor 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL13RA2 interleukin 13 receptor, alpha 2
IL18 interleukin 18
IL33 interleukin 33
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LITAF lipopolysaccharide-induced TNF factor
LTA lymphotoxin alpha
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PARP1 poly (ADP-ribose) polymerase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SPHK1 sphingosine kinase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBE2N ubiquitin-conjugating enzyme E2N