decreased retinal ganglion cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain (Mammalian Phenotype Ontology, MP_0006309)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006309
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Genes

22 gene mutations causing the decreased retinal ganglion cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ATOH7 atonal homolog 7 (Drosophila)
BARHL2 BarH-like homeobox 2
BCAR3 breast cancer anti-estrogen resistance 3
E2F1 E2F transcription factor 1
FASLG Fas ligand (TNF superfamily, member 6)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPA1 optic atrophy 1 (autosomal dominant)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTX2 orthodenticle homeobox 2
PAX2 paired box 2
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
POU4F2 POU class 4 homeobox 2
PXDN peroxidasin
RPL24 ribosomal protein L24
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMOC1 SPARC related modular calcium binding 1
SOD1 superoxide dismutase 1, soluble
TRIM2 tripartite motif containing 2