decreased liver triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liverower than normal concentration of triacylglycerols in the liver (Mammalian Phenotype Ontology, MP_0009356)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009356
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Genes

52 gene mutations causing the decreased liver triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACOT13 acyl-CoA thioesterase 13
ADIPOR2 adiponectin receptor 2
AGRP agouti related neuropeptide
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CES1 carboxylesterase 1
CRBN cereblon
CXCL14 chemokine (C-X-C motif) ligand 14
DGAT1 diacylglycerol O-acyltransferase 1
FABP1 fatty acid binding protein 1, liver
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
INS insulin
JUND jun D proto-oncogene
LEP leptin
LIPE lipase, hormone-sensitive
LRP6 low density lipoprotein receptor-related protein 6
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MGLL monoglyceride lipase
NEGR1 neuronal growth regulator 1
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLIN2 perilipin 2
PLIN5 perilipin 5
PPARD peroxisome proliferator-activated receptor delta
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
RETN resistin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SIK3 SIK family kinase 3
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOCS2 suppressor of cytokine signaling 2
SRA1 steroid receptor RNA activator 1
SREBF1 sterol regulatory element binding transcription factor 1
SSFA2 sperm specific antigen 2
STARD10 StAR-related lipid transfer (START) domain containing 10
TLR4 toll-like receptor 4