decreased interleukin-12 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells (Mammalian Phenotype Ontology, MP_0008664)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008664
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Genes

26 gene mutations causing the decreased interleukin-12 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
BCL3 B-cell CLL/lymphoma 3
CCR6 chemokine (C-C motif) receptor 6
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CLIC4 chloride intracellular channel 4
FLT3 fms-related tyrosine kinase 3
GADD45B growth arrest and DNA-damage-inducible, beta
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IL15 interleukin 15
LAT2 linker for activation of T cells family, member 2
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MAVS mitochondrial antiviral signaling protein
MYD88 myeloid differentiation primary response 88
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
PELI1 pellino E3 ubiquitin protein ligase 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SPP1 secreted phosphoprotein 1
TLR2 toll-like receptor 2
TLR6 toll-like receptor 6
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNIP1 TNFAIP3 interacting protein 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIB1 tribbles pseudokinase 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2