decreased interleukin-10 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation (Mammalian Phenotype Ontology, MP_0008661)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008661
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Genes

35 gene mutations causing the decreased interleukin-10 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
CARD9 caspase recruitment domain family, member 9
CCR1 chemokine (C-C motif) receptor 1
CCR4 chemokine (C-C motif) receptor 4
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CLEC4E C-type lectin domain family 4, member E
CLEC6A C-type lectin domain family 6, member A
DUSP4 dual specificity phosphatase 4
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOS FBJ murine osteosarcoma viral oncogene homolog
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IL13 interleukin 13
IL17RB interleukin 17 receptor B
IL20RB interleukin 20 receptor beta
IL4 interleukin 4
IL4R interleukin 4 receptor
LIF leukemia inhibitory factor
LPAR2 lysophosphatidic acid receptor 2
MYD88 myeloid differentiation primary response 88
NFIL3 nuclear factor, interleukin 3 regulated
ORAI1 ORAI calcium release-activated calcium modulator 1
PELI1 pellino E3 ubiquitin protein ligase 1
SASH3 SAM and SH3 domain containing 3
SDC1 syndecan 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
TIGIT T cell immunoreceptor with Ig and ITIM domains
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14