decreased interleukin-1 beta secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane (Mammalian Phenotype Ontology, MP_0008658)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008658
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Genes

24 gene mutations causing the decreased interleukin-1 beta secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIM2 absent in melanoma 2
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL13 chemokine (C-C motif) ligand 13
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD200R1 CD200 receptor 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GBP5 guanylate binding protein 5
IFNB1 interferon, beta 1, fibroblast
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL33 interleukin 33
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PILRB paired immunoglobin-like type 2 receptor beta
PYCARD PYD and CARD domain containing
STAT1 signal transducer and activator of transcription 1, 91kDa
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4