decreased interleukin-1 alpha secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active (Mammalian Phenotype Ontology, MP_0008655)
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5 gene mutations causing the decreased interleukin-1 alpha secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CASP4 caspase 4, apoptosis-related cysteine peptidase
CXCL6 chemokine (C-X-C motif) ligand 6
IL33 interleukin 33
NLRP1 NLR family, pyrin domain containing 1
PYCARD PYD and CARD domain containing