decreased interferon-beta secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity (Mammalian Phenotype Ontology, MP_0008565)
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18 gene mutations causing the decreased interferon-beta secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CC2D1A coiled-coil and C2 domain containing 1A
CD200R1 CD200 receptor 1
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAVS mitochondrial antiviral signaling protein
NLRC5 NLR family, CARD domain containing 5
PELI1 pellino E3 ubiquitin protein ligase 1
RSAD2 radical S-adenosyl methionine domain containing 2
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TLR9 toll-like receptor 9
TRADD TNFRSF1A-associated via death domain