decreased enteric neural crest cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description a reduction in the number of neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut (Mammalian Phenotype Ontology, MP_0013002)
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2 gene mutations causing the decreased enteric neural crest cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
PHOX2B paired-like homeobox 2b
RET ret proto-oncogene