decreased circulating triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver (Mammalian Phenotype Ontology, MP_0002644)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002644
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Genes

133 gene mutations causing the decreased circulating triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABHD5 abhydrolase domain containing 5
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGRP agouti related neuropeptide
AHSG alpha-2-HS-glycoprotein
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOF apolipoprotein F
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARRDC3 arrestin domain containing 3
BAG3 BCL2-associated athanogene 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF80 chromosome 19 open reading frame 80
C3 complement component 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAPZB capping protein (actin filament) muscle Z-line, beta
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEA cell death-inducing DFFA-like effector a
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLPS colipase, pancreatic
CNOT3 CCR4-NOT transcription complex, subunit 3
CRHR2 corticotropin releasing hormone receptor 2
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
DLL1 delta-like 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMOD1 ELMO/CED-12 domain containing 1
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FAM117B family with sequence similarity 117, member B
FFAR1 free fatty acid receptor 1
FGF23 fibroblast growth factor 23
FOXA1 forkhead box A1
FOXO1 forkhead box O1
G6PC2 glucose-6-phosphatase, catalytic, 2
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GHR growth hormone receptor
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSTK1 glutathione S-transferase kappa 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HNF4A hepatocyte nuclear factor 4, alpha
HPN hepsin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGFBP3 insulin-like growth factor binding protein 3
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSIG1 insulin induced gene 1
KISS1R KISS1 receptor
KLB klotho beta
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIF leukemia inhibitory factor
LIPE lipase, hormone-sensitive
LMNA lamin A/C
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MC3R melanocortin 3 receptor
MFSD2A major facilitator superfamily domain containing 2A
MGLL monoglyceride lipase
MIA2 melanoma inhibitory activity 2
MIR122 microRNA 122
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
MTTP microsomal triglyceride transfer protein
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NKX2-3 NK2 homeobox 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NXPH4 neurexophilin 4
OSTM1 osteopetrosis associated transmembrane protein 1
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITPNA phosphatidylinositol transfer protein, alpha
PITX3 paired-like homeodomain 3
PLA2G12B phospholipase A2, group XIIB
PLIN2 perilipin 2
PNPLA2 patatin-like phospholipase domain containing 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3B protein phosphatase 1, regulatory subunit 3B
RNF10 ring finger protein 10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SGMS2 sphingomyelin synthase 2
SGOL2 shugoshin-like 2 (S. pombe)
SIK3 SIK family kinase 3
SIRT7 sirtuin 7
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC38A10 solute carrier family 38, member 10
SLC51A solute carrier family 51, alpha subunit
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
STARD10 StAR-related lipid transfer (START) domain containing 10
THRB thyroid hormone receptor, beta
TMEM167A transmembrane protein 167A
TNF tumor necrosis factor
TRPC3 transient receptor potential cation channel, subfamily C, member 3
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
USHBP1 Usher syndrome 1C binding protein 1
WWOX WW domain containing oxidoreductase