decreased circulating interleukin-6 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts (Mammalian Phenotype Ontology, MP_0008597)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008597
Similar Terms
Downloads & Tools

Genes

40 gene mutations causing the decreased circulating interleukin-6 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARID5A AT rich interactive domain 5A (MRF1-like)
BBS12 Bardet-Biedl syndrome 12
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5AR1 complement component 5a receptor 1
CD14 CD14 molecule
CD19 CD19 molecule
CLIC4 chloride intracellular channel 4
CTSC cathepsin C
CXCL6 chemokine (C-X-C motif) ligand 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FOXN1 forkhead box N1
HSPB8 heat shock 22kDa protein 8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
MAVS mitochondrial antiviral signaling protein
MYD88 myeloid differentiation primary response 88
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NMU neuromedin U
PELI1 pellino E3 ubiquitin protein ligase 1
PGLYRP2 peptidoglycan recognition protein 2
PILRB paired immunoglobin-like type 2 receptor beta
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPP1 secreted phosphoprotein 1
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOLLIP toll interacting protein
TRADD TNFRSF1A-associated via death domain
TXNDC2 thioredoxin domain containing 2 (spermatozoa)
UNC93B1 unc-93 homolog B1 (C. elegans)