decreased circulating interleukin-12 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells (Mammalian Phenotype Ontology, MP_0008618)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008618
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Genes

9 gene mutations causing the decreased circulating interleukin-12 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
FLT3 fms-related tyrosine kinase 3
IFNGR1 interferon gamma receptor 1
IL12A interleukin 12A
IL22 interleukin 22
IL6 interleukin 6
NPY1R neuropeptide Y receptor Y1
TRPM2 transient receptor potential cation channel, subfamily M, member 2