death-inducing signaling complex Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. (Gene Ontology, GO_0031264)
External Link http://amigo.geneontology.org/amigo/term/GO:0031264
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Genes

8 proteins localized to the death-inducing signaling complex cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAS Fas cell surface death receptor
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
TRADD TNFRSF1A-associated via death domain