death-inducing signaling complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. (Gene Ontology, GO_0031264)
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89 proteins co-occuring with the death-inducing signaling complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CASP8 caspase 8, apoptosis-related cysteine peptidase 2.91803
FADD Fas (TNFRSF6)-associated via death domain 2.86885
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.4503
CFLAR CASP8 and FADD-like apoptosis regulator 1.81849
FASLG Fas ligand (TNF superfamily, member 6) 1.81647
CASP10 caspase 10, apoptosis-related cysteine peptidase 1.76045
TRADD TNFRSF1A-associated via death domain 1.60069
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.39183
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.34338
AATF apoptosis antagonizing transcription factor 1.29264
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.14494
FAF1 Fas (TNFRSF6) associated factor 1 1.11786
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.10919
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.10766
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.998577
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.983419
PEA15 phosphoprotein enriched in astrocytes 15 0.959268
BCL2L1 BCL2-like 1 0.955439
CARD17 caspase recruitment domain family, member 17 0.938795
DIABLO diablo, IAP-binding mitochondrial protein 0.925135
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.873647
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.870885
DEDD death effector domain containing 0.811652
TNF tumor necrosis factor 0.805689
APAF1 apoptotic peptidase activating factor 1 0.797895
DOPEY1 dopey family member 1 0.727494
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.723472
BIRC2 baculoviral IAP repeat containing 2 0.661208
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.657326
TRAF2 TNF receptor-associated factor 2 0.657326
CASP8AP2 caspase 8 associated protein 2 0.656464
MLKL mixed lineage kinase domain-like 0.632024
BAX BCL2-associated X protein 0.574244
MADD MAP-kinase activating death domain 0.572994
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.492966
PARP1 poly (ADP-ribose) polymerase 1 0.4865
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.48005
STYK1 serine/threonine/tyrosine kinase 1 0.475223
MAPK8 mitogen-activated protein kinase 8 0.465998
SCAF11 SR-related CTD-associated factor 11 0.461199
BFAR bifunctional apoptosis regulator 0.452427
CD40LG CD40 ligand 0.428678
JUN jun proto-oncogene 0.422782
HTRA2 HtrA serine peptidase 2 0.420428
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.396648
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.39471
MKRN1 makorin ring finger protein 1 0.383124
BID BH3 interacting domain death agonist 0.367006
TP53 tumor protein p53 0.360133
GMDS GDP-mannose 4,6-dehydratase 0.354802
EGFR epidermal growth factor receptor 0.334733
FAM188A family with sequence similarity 188, member A 0.320451
EN1 engrailed homeobox 1 0.320077
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.313344
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.304399
TMEM43 transmembrane protein 43 0.296972
BIRC5 baculoviral IAP repeat containing 5 0.26385
PRPF31 pre-mRNA processing factor 31 0.260931
IL1B interleukin 1, beta 0.24894
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.243519
BIRC3 baculoviral IAP repeat containing 3 0.239197
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.222083
MET MET proto-oncogene, receptor tyrosine kinase 0.221025
CUL3 cullin 3 0.21646
STAP2 signal transducing adaptor family member 2 0.215761
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.20574
SCYL1 SCY1-like 1 (S. cerevisiae) 0.196339
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.193394
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.190814
NUCB2 nucleobindin 2 0.18796
RHD Rh blood group, D antigen 0.179459
CD40 CD40 molecule, TNF receptor superfamily member 5 0.179459
PTEN phosphatase and tensin homolog 0.177154
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.173543
RIPK3 receptor-interacting serine-threonine kinase 3 0.172468
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.168101
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.167125
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.167125
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.166884
TP73 tumor protein p73 0.160658
ING4 inhibitor of growth family, member 4 0.157943
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.157218
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.140724
MTDH metadherin 0.140044
UBD ubiquitin D 0.138706
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.138015
NGDN neuroguidin, EIF4E binding protein 0.137127
SUMO1 small ubiquitin-like modifier 1 0.135227
BTK Bruton agammaglobulinemia tyrosine kinase 0.130857