dantrolene-3867 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dantrolene-3867 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACO2 aconitase 2, mitochondrial
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADCK4 aarF domain containing kinase 4
AKAP5 A kinase (PRKA) anchor protein 5
ANK1 ankyrin 1, erythrocytic
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APOC1 apolipoprotein C-I
ARC activity-regulated cytoskeleton-associated protein
ATN1 atrophin 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BTF3P11 basic transcription factor 3 pseudogene 11
C21ORF2 chromosome 21 open reading frame 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CARTPT CART prepropeptide
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEP112 centrosomal protein 112kDa
CEP250 centrosomal protein 250kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLDN17 claudin 17
CLEC11A C-type lectin domain family 11, member A
CLEC3B C-type lectin domain family 3, member B
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNTN1 contactin 1
COLEC12 collectin sub-family member 12
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DGAT1 diacylglycerol O-acyltransferase 1
DOK2 docking protein 2, 56kDa
DUX1 double homeobox 1
EDDM3B epididymal protein 3B
EGF epidermal growth factor
ELAC2 elaC ribonuclease Z 2
ERC2-IT1 ERC2 intronic transcript 1
FAXDC2 fatty acid hydroxylase domain containing 2
FCMR Fc fragment of IgM receptor
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF5 fibroblast growth factor 5
FGL2 fibrinogen-like 2
FLJ11292
FN1 fibronectin 1
FPR1 formyl peptide receptor 1
FST follistatin
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GGT1 gamma-glutamyltransferase 1
GHRH growth hormone releasing hormone
GRM7 glutamate receptor, metabotropic 7
HEXA-AS1 HEXA antisense RNA 1
HIST1H2AK histone cluster 1, H2ak
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPS1 Hermansky-Pudlak syndrome 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICOSLG inducible T-cell co-stimulator ligand
INHA inhibin, alpha
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIFC3 kinesin family member C3
LTBP4 latent transforming growth factor beta binding protein 4
MFGE8 milk fat globule-EGF factor 8 protein
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MIER2 mesoderm induction early response 1, family member 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYBPC3 myosin binding protein C, cardiac
MYO9B myosin IXB
NECAB2 N-terminal EF-hand calcium binding protein 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NHLH2 nescient helix loop helix 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSBPL10 oxysterol binding protein-like 10
PAIP2B poly(A) binding protein interacting protein 2B
PGAP3 post-GPI attachment to proteins 3
PGLYRP4 peptidoglycan recognition protein 4
PGR progesterone receptor
PHOX2B paired-like homeobox 2b
POM121 POM121 transmembrane nucleoporin
PRDX2 peroxiredoxin 2
PRKCB protein kinase C, beta
PRLH prolactin releasing hormone
PSCA prostate stem cell antigen
RAP1GAP RAP1 GTPase activating protein
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REEP2 receptor accessory protein 2
RNF126P1 ring finger protein 126 pseudogene 1
RSG1 REM2 and RAB-like small GTPase 1
SAFB scaffold attachment factor B
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGCE sarcoglycan, epsilon
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SPEG SPEG complex locus
TICAM1 toll-like receptor adaptor molecule 1
TMOD1 tropomodulin 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TUBBP5 tubulin, beta pseudogene 5
WNT16 wingless-type MMTV integration site family, member 16

decreased expression

Symbol Name
ACTL8 actin-like 8
AFAP1 actin filament associated protein 1
AMH anti-Mullerian hormone
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
AXIN1 axin 1
BAHCC1 BAH domain and coiled-coil containing 1
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
C14ORF132 chromosome 14 open reading frame 132
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC132 coiled-coil domain containing 132
CCDC186 coiled-coil domain containing 186
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CHM choroideremia (Rab escort protein 1)
CLDN1 claudin 1
CRLF1 cytokine receptor-like factor 1
CSAD cysteine sulfinic acid decarboxylase
CXADR coxsackie virus and adenovirus receptor
DAPK3 death-associated protein kinase 3
DBR1 debranching RNA lariats 1
DEXI Dexi homolog (mouse)
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
FANCC Fanconi anemia, complementation group C
FGF23 fibroblast growth factor 23
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FOXI1 forkhead box I1
FUBP3 far upstream element (FUSE) binding protein 3
GAMT guanidinoacetate N-methyltransferase
GRHL2 grainyhead-like 2 (Drosophila)
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTF2I general transcription factor IIi
HLA-J major histocompatibility complex, class I, J (pseudogene)
HP1BP3 heterochromatin protein 1, binding protein 3
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI30 interferon, gamma-inducible protein 30
IPO8 importin 8
IQSEC2 IQ motif and Sec7 domain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM7A lysine (K)-specific demethylase 7A
KIAA0125 KIAA0125
KIF23 kinesin family member 23
KREMEN2 kringle containing transmembrane protein 2
MAVS mitochondrial antiviral signaling protein
MCOLN1 mucolipin 1
MICB MHC class I polypeptide-related sequence B
MRPL52 mitochondrial ribosomal protein L52
MTG1 mitochondrial ribosome-associated GTPase 1
MUC3A mucin 3A, cell surface associated
NOL10 nucleolar protein 10
NOL6 nucleolar protein 6 (RNA-associated)
NPM3 nucleophosmin/nucleoplasmin 3
OTUD3 OTU deubiquitinase 3
PARG poly (ADP-ribose) glycohydrolase
PIDD1 p53-induced death domain protein 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRKCE protein kinase C, epsilon
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF113A ring finger protein 113A
RNF167 ring finger protein 167
RPS14P3 ribosomal protein S14 pseudogene 3
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUFY1 RUN and FYVE domain containing 1
S100A2 S100 calcium binding protein A2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SND1-IT1 SND1 intronic transcript 1
SNX27 sorting nexin family member 27
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STON1 stonin 1
TBX19 T-box 19
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TMEM51 transmembrane protein 51
TONSL tonsoku-like, DNA repair protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TWISTNB TWIST neighbor
UBL4A ubiquitin-like 4A
USP32 ubiquitin specific peptidase 32
VASH2 vasohibin 2
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
WWC2 WW and C2 domain containing 2
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF227 zinc finger protein 227
ZNF358 zinc finger protein 358
ZNF85 zinc finger protein 85